Risk of Stroke in Women Exposed to Low-Dose Oral Contraceptives

Chan, Wee‐Shian; Ray, Joel G.; Wai, Eugene K.; Ginsburg, Shiphra; Hannah, Mary E.; Corey, Paul; Ginsberg, Jeffrey S.

doi:10.1001/archinte.164.7.741

Cited by 150 publications

(93 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…• Contraception et traitement hormonal substitutif Le rôle des hormones féminines dans la survenue de la pathologie cérébrovasculaire a été également étudié. Ainsi, la contraception orale est associée à un risque accru d'IC avec un risque relatif compris entre 2 et 4 [24]. L'association existe quel que soit le type de pilule et son dosage en oestrogènes, même si elle est plus faible avec les pilules microdosées (< 50 μg d'oestrogènes).…”

Section: Risque Attribuableunclassified

Épidémiologie des accidents vasculaires cérébraux

Béjot

Touzé²,

Jacquin

et al. 2009

Med Sci (Paris)

View full text Add to dashboard Cite

Les AVC sont définis par l'Organisation mondiale de la santé (OMS) comme « le développement rapide de signes cliniques localisés ou globaux de dysfonction cérébrale avec des symptômes durant plus de vingtquatre heures pouvant entraîner la mort, sans autre cause apparente qu'une origine vasculaire ». Ce terme désigne en fait des affections très hétérogènes : les infarctus cérébraux (IC), représentant 80 à 90 % des AVC, les hémorragies intracérébrales (HIC) dans 10 à 20 % des cas, et les hémorragies méningées qui comptent pour moins de 2 % des AVC et qui ne seront pas abordées dans cet article. Bien que les IC et les HIC partagent certains facteurs de risque, leurs causes sont très différentes (Tableau I). Incidence des AVCIncidence en France La mesure de l'incidence annuelle des AVC, définie comme le nombre de nouveaux cas survenant au cours d'une année, est difficile à l'échelon national car elle implique un recueil exhaustif des cas [1]. En France, le seul registre de population disponible est celui de Dijon (150 000 habitants), qui étudie depuis 1985 l'épidémiologie des AVC. Incidence mondiale À travers le monde, ce sont 16 millions de nouveaux cas qui sont observés chaque année, responsables de 5,7 millions de décès [4]. Des disparités d'incidence annuelle des AVC ont été mises en évidence, celle-ci variant de 113 à 410 cas/100 000 personnes/an (Figure 1). Il existe un gradient décroissant nord-sud et est-ouest qui implique probablement à la fois des facteurs génétiques et environnementaux qui sont mal identifiés [1]. Des incidences élevées ont également été constatées dans les pays nordiques (Danemark, Norvège). Aucune donnée d'incidence provenant de registres de population n'est disponible pour les pays d'Afrique sub-saharienne. Néanmoins, les études épidémiologiques hospitalières font état d'une incidence globale plus faible que celle qui est observée dans les pays développés, sauf chez les sujets jeunes, et le développement économique de ces régions pourrait conduire à une forte augmentation de cette dernière dans les années à venir [5]. Évolution temporelle récente de l'incidenceSeules six études ont analysé l'évolution de l'incidence entre la fin du XX e siècle et le début du XXI e siècle [2]. Ainsi, > L'épidémiologie des accidents vasculaires céré-braux (AVC) a bénéficié au cours de ces vingt-cinq dernières années d'avancées majeures. D'une part, les registres de population ont permis une meilleure approche de l'incidence de cette pathologie à travers le monde. Accidents vasculaires cérébraux (1)Article disponible sur le site http://www.medecinesciences.org ou http://dx

show abstract

Section: Risque Attribuableunclassified

Épidémiologie des accidents vasculaires cérébraux

Béjot

Touzé²,

Jacquin

et al. 2009

Med Sci (Paris)

View full text Add to dashboard Cite

show abstract

“…In the research by Chan et al, the risk of stroke due to consumption of OCPs (0.51 -1.76) was related to thrombotic but not hemorrhagic stroke. Besides, the incidence of stroke was doubtful in low doses of OCPs (11). In another study, the risk of death within 28 days after the incidence of myocardial infarction was 2.88 folds (1.22 -6.77) higher among the consumers of OCPs compared to the non-consumers.…”

Section: Discussionmentioning

confidence: 96%

“…In a systematic meta-analysis, Chan et al investigated 20 studies and showed that the risk of stroke as the result of OCPs was only related to thrombotic but not hemorrhagic stroke (11). Furthermore, another study indicated that consumption of OCPs increased the risk of stroke in migraine sufferers, irrespective of other risk factors (12).…”

Section: Investigation Of the Relationship Between Myocardial Infarctmentioning

confidence: 99%

Investigation of the Relationship between Myocardial Infarction, Angina Pectoris, and Venous Thrombosis and Some Risk Factors in the Women Suffering from Cardiovascular Diseases with a History of Contraceptive Pills Consumption

Akbarzade

Sharifi

Zare

2016

Int Cardiovasc Res J

View full text Add to dashboard Cite

A B S T R A C TBackground: Cardiovascular diseases have various etiologies. Previous studies have come to contradictory results regarding the effects of Oral Contraceptive Pills (OCPs) on the risk of myocardial infarction, angina pectoris, and venous thrombosis. Thus, further investigation is required in this area. Objectives: This study aimed to determine the relationship between cardiovascular diseases and some risk factors in the women with a history of contraceptive pills consumption. Patients and Methods:The present case-control study was conducted on 317 women with cardiovascular diseases (myocardial infarction, angina pectoris, and deep venous thrombosis) selected through simple purposive sampling from CCU, ICU, post-ICU, and neurology departments of Nemazee, Faghihi, and Al-Zahra heart hospitals. Also, 371 controls were selected among 20 -60 year-old women without cardiac diseases. The data were collected through questionnaires, interviewing the patients and their firstdegree relatives, and the patients' medical records. The main variables studied in both groups included the history of OCPs consumption, weight gain, blood sugar level, and hypertension. Then, the data were analyzed using chi-square test, correlation coefficient, and odds ratio. Besides, P < 0.05 was considered to be statistically significant. Results: The mean age of the study population was 49.2 ± 13.4 years. Besides, 10.6%, 4%, and 2.7% of the women had used OCPs for 6 -10, 11 -15, and more than 16 years, respectively. There were no significant differences between the two groups in terms of history of using OCPs (47.3% vs. 51.5%, P = 0.8). In addition, no significant relationship was observed between consumption of OCPs and incidence of myocardial infarction (P = 0.202), angina pectoris (P = 0.260), and thrombosis (P = 0.389). However, a significant difference was found between the two groups regarding the frequency of hyperlipidemia, hyperglycemia, and hypertension (P < 0.001). Conclusions:The results showed no significant association between the use of OCPs and cardiovascular diseases. Nevertheless, other risk factors of cardiovascular diseases were higher among the patients with a history of contraceptive pills consumption.

show abstract

“…Cerebrovascular accident (CVA) is another very rare blood disease among women at the reproductive age 43 . However, there is a higher incidence of cases among users of COC compared to non-users 44,45 . When Heinemann 46 examined epidemiological articles published, it was possible to conclude that high doses of EE (≥ 50 mcg) were associated with increased risk of stroke compared to formulations with 50 mcg of EE (OR:5.3; 95% CI: 2.6-11 versus OR: 1.53; 95% CI: 0.71-3.31) 47 .…”

Section: Hormonal Contraception and Arterial Thrombosismentioning

confidence: 97%

Contracepção hormonal e sistema cardiovascular

Brito

Nobre²,

Vieira

2011

Arq. Bras. Cardiol.

View full text Add to dashboard Cite

Hormonal contraception is the most widely used method to prevent unplanned pregnancies. The literature has shown an association between cardiovascular risk and use of hormone therapy. With the purpose of providing better guidelines on contraception methods for women with risk factors for cardiovascular disease, we have reviewed the literature on the subject. This review describes the latest data from the scientific literature concerning the influence of hormonal contraceptives on arterial thrombosis, venous thrombosis and systemic high blood pressure, which are diseases that have become increasingly prevalent among young females.

show abstract

Risk of Stroke in Women Exposed to Low-Dose Oral Contraceptives

Abstract: These results cast doubt on a true association between low-dose OCPs and stroke because of the low absolute magnitude of the ORs, the severe methodological limitations, and the ORs of less than 1.0 in the cohort studies. The association is tenuous at best and perhaps nonexistent.

Cited by 150 publications

References 59 publications

Épidémiologie des accidents vasculaires cérébraux

Épidémiologie des accidents vasculaires cérébraux

Investigation of the Relationship between Myocardial Infarction, Angina Pectoris, and Venous Thrombosis and Some Risk Factors in the Women Suffering from Cardiovascular Diseases with a History of Contraceptive Pills Consumption

Contracepção hormonal e sistema cardiovascular

Contact Info

Product

Resources

About