Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Associated With Antibiotic Use: A Case-Crossover Study

Fukasawa, Toshiki; Urushihara, Hisashi; Takahashi, Hayato; Okura, Takayuki; Kawakami, Koji

doi:10.1016/j.jaip.2023.07.012

Cited by 7 publications

(2 citation statements)

References 46 publications

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“…The assessment of the risk of SJS and TEN associated with different antibiotic classes performed in Japan demonstrated maximum odds ratios for lincomycins (33.00 [95% CI, 3.74–4332.05]), sulfamethoxazole trimethoprim (21.20 [6.73–105.98]), penicillins (14.39 [6.95–34.21]), glycopeptides (14.37 [3.17–136.10]), cephalosporins (7.06 [4.25–12.21]), aminoglycosides (6.55 [1.97–26.84]), quinolones (5.98 [3.34–11.20]), fosfomycin (5.40 [1.20–30.97]), carbapenems (5.09 [1.85–15.64]), tetracyclines (4.95 [1.78–15.27]), and macrolides (3.78 [2.13–6.83]) [ 48 ]. Sulfonamides (mainly sulfamethoxazole trimethoprim) were reported by many researchers among the most common culprit drugs for SJS and TEN among anti-infectives.…”

Section: Discussionmentioning

confidence: 99%

Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Analysis of the Russian Database of Spontaneous Reports

Zyryanov,

Asetskaya,

Butranova

et al. 2024

Pharmaceuticals

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(1) Background: Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are extremely severe cutaneous adverse drug reactions which are relatively rare in routine clinical practice. An analysis of a national pharmacovigilance database may be the most effective method of obtaining information on SJS and TEN. (2) Methods: Design—a retrospective descriptive pharmacoepidemiologic study of spontaneous reports (SRs) with data on SJS and TEN retrieved from the Russian National Pharmacovigilance database for the period from 1 April 2019 to 31 December 2023. Descriptive statistics was used to assess the demographic data of patients and the structure of suspected drugs. (3) Results: A total of 170 SRs on SJS and TEN were identified, of which 32.9% were SJS and 67.1%—TEN. In total, 30% were pediatric SRs, 21.2%—SRs of the elderly. There were 12 lethal cases, and all cases were TEN. The leading culprit drugs were anti-infectives for systemic use and nervous system agents. The top 10 involved drugs are as follows: lamotrigine (23.5%), ibuprofen (12.9%), ceftriaxone (8.8%), amoxicillin and amoxicillin with beta-lactam inhibitors (8.8%), paracetamol (7.6%), carbamazepine (5.9%), azithromycin (4.1%), valproic acid (4.1%), omeprazole (3.5%), and levetiracetam (3.5%). (4) Conclusions: Our study was the first study in Russia aimed at the assessment of the structure of the drugs involved in SJS and TEN on the national level.

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Section: Discussionmentioning

confidence: 99%

Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Analysis of the Russian Database of Spontaneous Reports

Zyryanov,

Asetskaya,

Butranova

et al. 2024

Pharmaceuticals

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“…These diagnoses, prescriptions, and procedures are coded using the International Classification of Diseases, Tenth Revision (ICD-10) codes, the Anatomical Therapeutic Chemical (ATC) codes together with the Japan-specific YJ (Yakka Joho) codes (code according to the National Health Insurance Drug List), and the Japanese procedure codes. The advantage of the JMDC database is its ability to track an individual's medical information across different healthcare facilities under the same health insurance, making it widely used for epidemiology studies in Japan (Fukasawa et al, 2023;Masuda et al, 2023;S. Yoshida et al, 2022).…”

Section: Data Sourcementioning

confidence: 99%

Cardiovascular Safety of Atomoxetine and Methylphenidate in Patients With Attention-Deficit/Hyperactivity Disorder in Japan: A Self-Controlled Case Series Study

Zheng,

Fukasawa,

Yamaguchi

et al. 2023

J Atten Disord

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Objective: To investigate the association between atomoxetine or methylphenidate use and arrhythmia, heart failure (HF), stroke, and myocardial infarction (MI) in attention-deficit/hyperactivity disorder (ADHD) patients mainly focused on the people of working age. Methods: In a self-controlled case series study using a Japanese claims database, we identified events of arrhythmia, HF, stroke, and MI among 15,472 atomoxetine new users and 12,059 methylphenidate new users. Adjusted incidence rate ratios (aIRRs) of outcome events were estimated using multivariable conditional Poisson regression. Results: An increased risk of arrhythmia was observed during the first 7 days after the initial atomoxetine exposure (aIRR 6.22, 95% CI [1.90, 20.35]) and in the subsequent exposure (3.23, [1.58, 6.64]). No association was found between methylphenidate exposure and arrhythmia, nor between atomoxetine or methylphenidate exposure and HF. The limited number of stroke and MI cases prevented thorough analysis. Conclusions: Clinicians should consider monitoring for arrhythmia after patients initiating or re-initiating atomoxetine.

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Challenges in optimizing the treatment of Pneumocystis pneumonia in the intensive care unit. Author’s reply

Kamel,

Guisset,

Fillatre

et al. 2024

Intensive Care Med

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Risk of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Associated With Antibiotic Use: A Case-Crossover Study

Cited by 7 publications

References 46 publications

Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Analysis of the Russian Database of Spontaneous Reports

Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Analysis of the Russian Database of Spontaneous Reports

Cardiovascular Safety of Atomoxetine and Methylphenidate in Patients With Attention-Deficit/Hyperactivity Disorder in Japan: A Self-Controlled Case Series Study

Challenges in optimizing the treatment of Pneumocystis pneumonia in the intensive care unit. Author’s reply

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