Risk of Severe SARS-CoV-2 Infection in Patients with Autoimmune Rheumatic Diseases in Qatar: A Cohort Matched Study

Alsaed, Omar; Al‐Emadi, Samar; Satti, Eman; Becetti, Karima; Saleh, Rawan; Ashour, H.; Hamed, Manal; Alam, Fiaz; Alrimawi, Yousef; Nader, Joanne Daghfal; Chaponda, Masautso; Awadh, Basem; Hammoudeh, M.

doi:10.5339/qmj.2022.24

Cited by 1 publication

(1 citation statement)

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“…Several positive causal effects highlighted in MR analysis include pre‐existing diseases of the connective tissues between bones and tendons or ligaments, including diseases of the joints. It should be noted that a larger prevalence of severe COVID‐19 was previously reported for autoimmune rheumatic diseases 44 , 45 but not for osteoarthritis, thus indicating that the pathophysiological drivers of more severe COVID‐19 in patients with enthesopathies and allied syndromes may be related to the immune system.…”

Section: Discussionmentioning

confidence: 83%

A phenome‐wide investigation of risk factors for severe COVID‐19

Baranova

Cao

Teng

et al. 2022

Journal of Medical Virology

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With the continued spread of COVID‐19 globally, it is crucial to identify the potential risk or protective factors associated with COVID‐19. Here, we performed genetic correlation analysis and Mendelian randomization analysis to examine genetic relationships between COVID‐19 hospitalization and 405 health conditions and lifestyle factors in 456 422 participants from the UK Biobank. The genetic correlation analysis revealed 134 positive and 65 negative correlations, including those with intakes of a variety of dietary components. The MR analysis indicates that a set of body fat‐related traits, maternal smoking around birth, basal metabolic rate, lymphocyte count, peripheral enthesopathies and allied syndromes, blood clots in the leg, and arthropathy are causal risk factors for severe COVID‐19, while higher education attainment, physical activity, asthma, and never smoking status protect against the illness. Our findings have implications for risk stratification in patients with COVID‐19 and the prevention of its severe outcomes.

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Section: Discussionmentioning

confidence: 83%