Risk of serious ventricular arrhythmia and sudden cardiac death in a cohort of users of domperidone: a nested case‐control study

Abstract

The increased risk of SVA/SCD for current domperidone users remained after adjustment for multiple covariates. The risk may vary among subgroups of exposed individuals.

Domperidone-Associated Sudden Cardiac Death in the General Population and Implications for Use in Patients Undergoing Hemodialysis: A Literature Review

“…Similar to the study by Noord and others, 9 the strengths of the study by Johannes and others 10 included the large study population, the 15-year study period, and an appropriate data collection methodology. In addition, the 3-way comparison of domperidone use with non-use and PPI use may have strengthened the authors' findings by minimizing bias by indication.…”

“…In stratified analyses, the unadjusted OR for current domperidone use relative to non-use was numerically higher for case-control pairs without diabetes, for those older than 60 years, and for men. 10 The authors acknowledged that the 95% CIs for some of the stratified point estimates were wide, which reflected the small number of cases in those subgroups; however, the absolute numbers of cases were not specified. Specifically, the study reported a significantly higher risk of SCD among patients over 60 years of age (OR 1.64, 95% CI 1.31-2.05), but the result was nonsignificant among patients 60 years of age or younger (OR 1.10, 95% CI 0.35-3.37).…”

“…Review of the literature for humans cited as supporting the advisories from health regulatory agencies [6][7][8] showed that these advisories are based primarily on 2 observational epidemiological studies evaluating data derived from public health databases in the Netherlands 9 and the province of Saskatchewan in Canada, 10 both of which were also identified in the literature search for this narrative review. Noord and others 9 conducted a prospective, populationbased case-control study over the period 1996 to 2007 to evaluate the association between use of domperidone and both nonfatal cardiac arrhythmia and SCD in the general population.…”

Efectos adversos cardíacos de la domperidona en pacientes adultos: revisión sistemática

“…A partir de la lectura de los mismos se incorporaron 7 potenciales trabajos, dando un total de 30 artículos para una reevaluación detallada. Por los motivos indicados en la Figura 1, se excluyeron 27 artículos quedando un total de tres estudios [19][20][21] .…”

“…El único ítem que recibió la categorización de "riesgo incierto" en dos de los trabajos 19,20 , y con acuerdo de los revisores, fue "cegamiento de la exposición en la selección de los casos". Los requisitos restantes fueron respondidos satisfactoriamente en los tres estudios.…”