Risk of second primary malignancies in women with cervical cancer: A population-based study in Taiwan over a 30-year period

Chen, Chao Yu; Lai, Chyong‐Huey; Lee, Kuan Der; Huang, Shu‐Mei; Dai, Yen Mei; Chen, Min Chi

doi:10.1016/j.ygyno.2012.09.004

Cited by 27 publications

(30 citation statements)

References 33 publications

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“…This is in agreement with previous studies, which also report a heightened risk of head and neck cancers among survivors of cervical cancer. [2][3][4][5][6][7] Stratification based on UV-association increased this risk to over 8-fold of cancer of the oral cavity proper. The oropharynx had the highest risk for cancer development after cervical cancer of any head and neck region.…”

Section: Discussionmentioning

confidence: 99%

“…1 In relation to neoplasms of the cervix, previous studies suggest a heightened risk of carcinogenesis at distant epithelial sites, including the head and neck region ( Table 1). [2][3][4][5][6][7][8] Cervical cancer is an invasive neoplasm of the cervix, which accounts for almost 10% of female cancers worldwide. 9 The etiology of cervical cancer is closely related to the human papillomavirus (HPV).…”

Section: Introductionmentioning

confidence: 99%

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Heightened risk of second primary carcinoma of the head and neck following cervical neoplasia

2013

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Heightened risk of second primary carcinoma of the head and neck following cervical neoplasia

2013

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“…The burden is more pronounced in developing countries, due to lacking healthcare infrastructure, inequitable medical costs and secondary prevention failures [2][3][4]. The introduction of the Pap-test as a screening method has helped save millions of women's lives over the course of years [5].…”

Section: Introductionmentioning

confidence: 99%

PAX1 methylation as an auxiliary biomarker for cervical cancer screening: A meta-analysis

Nikolaidis

Nena

Παναγοπούλου

et al. 2015

Cancer Epidemiology

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“…However, premature ovarian failure due to treatment of cervical cancer and the shared radiotherapy field has not been considered or adequately discussed, as this complication may result in a decreased incidence of hormone-dependent cancers and pelvic tumors within the radiotherapy field. Poorer survival outcomes in women with a second primary cancer after the diagnosis and treatment of cervical cancer has been documented [ 9 ], although additional investigation regarding detailed survival outcomes according to the type of second primary cancer and survival outcomes from the onset of the second primary cancer is needed in order to obtain better clinical information for such patients. Therefore, the objective of this study was to investigate the incidence and survival outcomes of second primary cancers after the diagnosis and treatment of cervical cancer in a recent study cohort.…”

Section: Introductionmentioning

confidence: 99%

Second Primary Cancer after Diagnosis and Treatment of Cervical Cancer

et al. 2016

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PurposeThis study was conducted to investigate the incidence and survival outcomes of second primary cancers after the diagnosis of cervical cancer.Materials and MethodsData from the Korea Central Cancer Registry between 1993 and 2010 were reviewed and analyzed. Standardized incidence ratios (SIRs) of second primary cancers among women with cervical cancer were analyzed. Kaplan-Meier survival curves were constructed for cervical cancer patients with or without a second primary cancer.ResultsAmong 72,805 women with cervical cancer, 2,678 (3.68%) developed a second primary cancer within a mean follow-up period of 7.34 years. The overall SIR for a second cancer was 1.08 (95% confidence interval, 1.04 to 1.12). The most frequent sites of second primary cancers were the vagina, bone and joints, vulva, anus, bladder, lung and bronchus, corpus uteri, and esophagus. However, the incidence rates of four second primary cancers (breast, rectum, liver, and brain) were decreased. The 5-year and 10-year overall survival rates were 78.3% and 72.7% in all women with cervical cancer, and for women with a second primary cancer, these rates were 83.2% and 65.5% from the onset of cervical cancer and 54.9% and 46.7% from the onset of the second primary cancer, respectively.ConclusionThe incidence rates of second primary cancers were increased in women with cervical cancer compared to the general population, with the exception of four decreasing cancers. The 10-year overall survival rates were decreased in cervical cancer patients with a second primary cancer.

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Risk of second primary malignancies in women with cervical cancer: A population-based study in Taiwan over a 30-year period

Cited by 27 publications

References 33 publications

Heightened risk of second primary carcinoma of the head and neck following cervical neoplasia

Heightened risk of second primary carcinoma of the head and neck following cervical neoplasia

PAX1 methylation as an auxiliary biomarker for cervical cancer screening: A meta-analysis

Second Primary Cancer after Diagnosis and Treatment of Cervical Cancer

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