Risk of second primary cancer in oral squamous cell carcinoma

Mroueh, Rayan; Nevala, Aapeli; Haapaniemi, Aaro; Pitkäniemi, Janne; Salo, Tuula; Mäkitie, Antti

doi:10.1002/hed.26107

Cited by 17 publications

(23 citation statements)

References 49 publications

(46 reference statements)

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“…Mroueh et al found a second primary cancer in 10% of patients with oral squamous cell carcinoma in their cohort [3], while Min et al reported that the risk of a second primary oral cancer was higher (standardized incidence ratio 16.25, 95% con dence interval 13.04-20.02) than that of a non-oral second primary cancer (standardized incidence ratio 1.37, 95% con dence interval 1.29-1.45) in Korean patients with cancer in the oral cavity [4]. The highest relative risk for a second primary cancer in the oral cavity was observed in patients with oor of mouth cancer, followed by those with gingival and tongue cancers [3,4]. In patients with tongue carcinoma, the second primary cancer most frequently occurs in the oropharynx, followed by the esophagus and larynx [3,4].…”

Section: Discussionmentioning

confidence: 83%

“…The highest relative risk for a second primary cancer in the oral cavity was observed in patients with oor of mouth cancer, followed by those with gingival and tongue cancers [3,4]. In patients with tongue carcinoma, the second primary cancer most frequently occurs in the oropharynx, followed by the esophagus and larynx [3,4]. In contrast, second primary carcinomas at other sites, such as the intrahepatic bile duct, bladder, and prostate, are rare in patients with tongue carcinoma.…”

Section: Discussionmentioning

confidence: 98%

“…Patients with oral squamous cell carcinoma and those with other types of head and neck cancer are at higher risk of a second primary cancer than patients with cancers at most other sites [3]. Mroueh et al found a second primary cancer in 10% of patients with oral squamous cell carcinoma in their cohort [3], while Min et al reported that the risk of a second primary oral cancer was higher (standardized incidence ratio 16.25, 95% con dence interval 13.04-20.02) than that of a non-oral second primary cancer (standardized incidence ratio 1.37, 95% con dence interval 1.29-1.45) in Korean patients with cancer in the oral cavity [4]. The highest relative risk for a second primary cancer in the oral cavity was observed in patients with oor of mouth cancer, followed by those with gingival and tongue cancers [3,4].…”

Section: Discussionmentioning

confidence: 99%

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Left Supraclavicular (Virchow’s) Node Metastasis Detected Before Diagnosis of the Primary Infradiaphragmatic Tumor

Mochizuki¹,

Tsuchiya²,

Oyama³

et al. 2021

Preprint

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Background and Purpose: Malignant infradiaphragmatic tumors that metastasize to the left supraclavicular (Virchow’s) node are relatively rare. Since Virchow's time, the survival rates of cancer patients have improved because of dramatic research advances in the epidemiology of cancer and the development of screening technologies and treatment methods. However, when metastasis is detected in the left supraclavicular node in patients with head and neck carcinoma, locating the primary cancer remains a difficult and time-consuming challenge. We report three cases of malignant infradiaphragmatic tumors diagnosed following the initial finding of left supraclavicular node (LSN) metastasis after surgery for tongue squamous cell carcinoma (follow-up period, range 18–62 months).Methods: In these cases, adenocarcinoma was diagnosed based on LSN biopsies, and a second primary tumor was found, including cholangiocarcinoma, bladder carcinoma, and prostate carcinoma.Results: CA19-9 and alpha-fetoprotein levels helped to diagnose cholangiocarcinoma. In the bladder carcinoma case, immunopathological examination of the metastatic LSN and bladder lesion showed GATA 3(+), and the tongue squamous cell carcinoma showed GATA 3(-). GATA 3 staining aided in the diagnosis of urothelial bladder cancer with LSN metastasis. In the prostate carcinoma case, PSA levels and weak FDG-PET/CT uptake aided the diagnosis process. This patient underwent bilateral orchiectomy and adjuvant hormonal therapy and survived for 47 months after the diagnosis of LSN metastasis. The other patients died within 1 year.Discussion and Conclusions: These cases suggest that the prognosis of malignant infradiaphragmatic tumors after LSN metastasis depends on the tumor characteristics and that rapid diagnosis is important for providing appropriate treatment.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

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Left Supraclavicular (Virchow’s) Node Metastasis Detected Before Diagnosis of the Primary Infradiaphragmatic Tumor

Mochizuki¹,

Tsuchiya²,

Oyama³

et al. 2021

Preprint

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“…Early diagnosis is important for the treatment and prognosis of oral cancer. 15 – 17 Traditionally, invasion and metastasis are late events in the progression of oral cancer. 17 – 19 At present, it is believed that during the early stage of oral cancer, tumor cells have begun to infiltrate, 20 , 21 but the regulatory mechanism unclear.…”

Section: Discussionmentioning

confidence: 99%

circVAPA promotes the proliferation, migration and invasion of oral cancer cells through the miR-132/HOXA7 axis

Chen

Zhang

et al. 2021

J Int Med Res

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Objective To study the relationship between the circular RNA vesicle-associated membrane protein-associated protein A (circVAPA) and the pathogenesis of oral squamous cell carcinoma. Methods The expression of circVAPA was detected by RT-qPCR. In vitro loss-of-function experiments were performed in Cal-27 cells. The malignant phenotype of cells was evaluated by cell counting kit-8, clone formation and transwell assays. Luciferase reporter assays were used to assess the circVAPA/miR-132/homeobox A (HOXA) regulatory axis. Results circVAPA expression was significantly increased in oral cancer tissues and cells. The overall survival and progression-free survival of patients with oral cancer who exhibited high circVAPA expression were significantly shorter compared with those with low expression. circVAPA expression was closely related to tumor size, TNM stage and distant metastasis. circVAPA knockdown reduced the proliferation, invasion and migration of Cal-27 cells. MiR-132 was identified as a target of circVAPA in Cal-27 cells. Cotransfection with si-circVAPA and miR-132 inhibitor reversed the inhibitory effect of circVAPA knockdown on cell malignant phenotypes. HOXA7 was further identified as a downstream target of miR-132. Conclusion circVAPA is highly expressed in oral cancer, and its abnormal expression might affect the proliferation, invasion and migration of oral cancer cells by modulating the miR-132/HOXA7 signaling axis.

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“…According to several contemporary studies, ''field cancerization,'' which is the replacement of normal cell population by a cancer-primed cell population, is recognized to underlie the development of different types of cancer and it can explain the aerodigestive epithelium predisposition to develop multiple precancerous and cancerous lesions after the exposure to carcinogenic substances. 6 In addition, the frequent exposure to radiation of HNC survivors who are constantly checked-up and, therefore, most likely to be diagnosed with a second tumor, must also be considered as an influencing factor in the analysis of SPCs etiology. Finally, the detection of SPCs has lately been improved by the accuracy of sophisticated imaging modalities that can identify even the smallest lesions.…”

Section: Introductionmentioning

confidence: 99%

Three Synchronous Head and Neck Cancers: A Multidisciplinary and Surgical Challenge

Bertone

Robiolio

et al. 2021

Ear Nose Throat J

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Second primary cancer (SPC) is a term used to describe a new primary cancer occurring in patients who had formerly been diagnosed with tumor. Even though SPCs appear to be related to primary cancers, they are actually entities that have arisen independently and not as a result of recurrence. This report is of the first case in literature of a patient hospitalized for the surgical treatment of 3 synchronous Head and Neck Cancers. A 66-year-old male was admitted to our hospital (Ospedale Degli Infermi—Biella, Italy) complaining about pharyngodynia. Three different lesions were identified through endoscopic examination and narrow band imaging: the first one on left tonsil, the second one on epiglottis, and the third one on right aryepiglottic fold. The case was subject to a multidisciplinary team analysis due to its complexity, then the surgery consisted in (1) CO2 laser left tonsillectomy, associated with (2) CO2 laser excision of the lesion on epiglottis free edge, and (3) CO2 laser excision of right aryepiglottic fold lesion. Synchronous tumors are among the most defiant challenges for surgeons since no international guideline specifies differentiated strategies to be adopted in patients affected by synchronous Head and Neck Cancers, therefore surgical planning must be tailored differently from patient to patient, and many unsolved questions still concern clinical treatments to be adopted.

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Risk of second primary cancer in oral squamous cell carcinoma

Cited by 17 publications

References 49 publications

Left Supraclavicular (Virchow’s) Node Metastasis Detected Before Diagnosis of the Primary Infradiaphragmatic Tumor

Left Supraclavicular (Virchow’s) Node Metastasis Detected Before Diagnosis of the Primary Infradiaphragmatic Tumor

circVAPA promotes the proliferation, migration and invasion of oral cancer cells through the miR-132/HOXA7 axis

Three Synchronous Head and Neck Cancers: A Multidisciplinary and Surgical Challenge

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