Risk of second malignancy after cancers of the renal parenchyma, renal pelvis, and ureter

Kantor, Arlene F.; McLaughlin, Joseph K.; Curtis, Rochelle E.; Flannery, John; Fraumeni, Joseph F.

doi:10.1002/1097-0142(19860901)58:5<1158::aid-cncr2820580530>3.0.co;2-v

Cited by 33 publications

(20 citation statements)

References 10 publications

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“…The lower than expected rates of second primary lung cancer among patients included in this study are consistent with prior reports [10–12, 25]. Possible explanations for this finding could be that the survival of patients with an aggressive renal cortical neoplasm might be not long enough to allow for the development of a second smoking-related primary malignancy, or that these patients died of a smoking-related comorbidity before developing lung cancer.…”

Section: Discussionsupporting

confidence: 91%

Second primary malignancies in renal cortical neoplasms: an updated evaluation from a single institution

et al. 2016

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Purpose To examine the incidence of secondary primary malignancies in patients with renal cortical neoplasms. Methods Between January 1989 and July 2010, 3647 patients underwent surgery at our institution for a renal cortical neoplasm and were followed through 2012. Occurrence of other malignancies was classified as antecedent, synchronous, or subsequent. All patients with antecedent malignancies (n = 498) and a randomly selected half of those with synchronous malignancies (n = 83) were excluded. The expected number of second primaries was calculated by multiplying Surveillance, Epidemiology, and End Results Program incidence rates of renal cortical neoplasms by person-years at risk within categories of age, sex, and year of diagnosis. The standardized incidence ratio (SIR) was calculated as observed cancers divided by expected incidence of the cancer, with approximation to the exact Poisson test used to obtain confidence intervals (CI) and p values. Results Of 3066 patients with renal cortical neoplasms, 267 had a second primary cancer; the five most common in men were prostate, colorectal, bladder, lung, and non-Hodgkin’s lymphoma; the five most common in women were breast, colorectal, lung, endometrium, and thyroid. Men demonstrated higher than expected thyroid cancer rate (SIR 5.0; 95 % CI 1.83–10.88, p = 0.002), and women had higher than expected rates of stomach cancer (SIR 5.0; 95 % CI 1.61–11.67, p = 0.004) and thyroid cancer (SIR 4.62; 95 % CI 1.69–10.05, p = 0.003). Conclusions The incidence of certain types of second malignancies may be higher in patients after diagnosis of renal cortical neoplasms compared to the general population. These observations can inform clinical follow-up in kidney cancer survivorship and future research studies.

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Section: Discussionsupporting

confidence: 91%

Second primary malignancies in renal cortical neoplasms: an updated evaluation from a single institution

et al. 2016

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“…Lastly, we want to point out the issue of subsequent malignancies in nephrectomized patients. Second primary cancers were reported to have developed in approximately 7% of patients successfully treated for RCC 16 . The present study also showed that 10 of 289 (3.5%) patients with no other malignancies at kidney operation experienced subsequent malignancies.…”

Section: Discussionsupporting

confidence: 72%

Multiple primary malignancies in Japanese patients with renal cell carcinoma

et al. 2004

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Aim : To evaluate the incidence, nature and prognosis of multiple primary malignancies involving renal cell carcinoma (RCC) in Japan. Methods : Between 1975 and 1998, 319 patients underwent an operation for RCC at Hokkaido University, Sapporo, Japan. The incidence of other primary malignancies was determined and classified as antecedent, synchronous or subsequent. Follow-up was obtained by thorough chart review or telephone interview, and ranged from 0 to 276 months (median 49.0 months). To analyze the influence of other primary malignancies on prognosis, overall and cause-specific survival rates of the patients with an antecedent or synchronous malignancy were compared to the remaining patients.Results : Of the 319 patients there was at least one other malignancy in 38 patients (12%). Four patients had two other malignancies. The other malignancies were antecedent in 13, synchronous in 19 and subsequent in 10 patients. Twenty-two patients had gastrointestinal cancer. In cases of antecedent or synchronous diagnosis of other primary malignancies, RCC was commonly incidental, small or low-stage. Multivariate analysis using Cox's proportional hazards model showed that, for overall survival, the presence of other antecedent or synchronous malignancies was the second most significant prognostic factor, following the pathological stage of RCC. Conclusions : In Japanese patients with RCC, the incidence of other primary malignancies was not uncommon and these malignancies contributed to the prognosis of these patients. Therefore, the malignant potential of individual tumors should be paid careful attention in the management of these patients.

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“…An analysis of the Connecticut Tumor Registry showed a greater risk of prostate cancer after diagnosis of an initial cancer of the kidney, renal pelvis or ureter (SIR 1.5, P < 0.05, 22 059 person‐years) [3]. Analysis of these data showed that the incidence of prostate cancer after renal parenchymal cancers was only increased during the first year after diagnosis, while there was a more sustained increase with tumours of the renal pelvis and collecting system [4]. Men with an initial diagnosis of prostate cancer had no additional risk of developing cancer of the kidney, renal pelvis or ureter (SIR 1.1, not significant, 70 358 person‐years) [12].…”

Section: Discussionmentioning

confidence: 99%

A population‐based study of renal cell carcinoma and prostate cancer in the same patients

et al. 2005

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OBJECTIVETo investigate the incidence of prostate cancer in men with renal cell carcinoma (RCC) and the incidence of RCC in men with prostate cancer. METHODSWe evaluated the database of the Surveillance, Epidemiology and End Results Program of the National Cancer Institute from 1973 to 1996, to calculate the incidence of RCC in men with prostate cancer and the incidence of prostate cancer in men with RCC. The standardized incidence ratio (SIR, observed/expected) was calculated for each of the scenarios of interest, as well as for RCC and prostate cancer in men with other common malignancies. Lung/bronchus cancer, colon/rectal cancer, and non-Hodgkin lymphoma were selected for the control scenarios because they are the most common non-urological cancers among men in the USA. RESULTSThere was a higher incidence of RCC in men with prostate cancer (SIR 1.25, P < 0.01). RCC incidence was also higher in men with each of the other malignancies. Prostate cancer incidence was higher in men with RCC (SIR 1.42, P < 0.001), but was not significantly elevated for any of the control scenarios. CONCLUSIONSThe incidence of RCC is higher in men with each of the index cancers, whereas that for prostate cancer was higher only in men with RCC. A common aetiological factor is possible. However, it is also possible that detection bias explains these findings. Serial imaging might increase the detection of RCC among patients with a variety of index malignancies. Patients with RCC who are followed by a urologist might be screened more rigorously for prostate cancer than patients with other primary malignancies, leading to increased detection in these men.

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Risk of second malignancy after cancers of the renal parenchyma, renal pelvis, and ureter

Cited by 33 publications

References 10 publications

Second primary malignancies in renal cortical neoplasms: an updated evaluation from a single institution

Second primary malignancies in renal cortical neoplasms: an updated evaluation from a single institution

Multiple primary malignancies in Japanese patients with renal cell carcinoma

A population‐based study of renal cell carcinoma and prostate cancer in the same patients

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