Risk of Salivary Gland Cancer After Childhood Cancer: A Report From the Childhood Cancer Survivor Study

Boukheris, Houda; Stovall, Marilyn; Gilbert, Ethel S.; Stratton, Kayla; Smith, Susan A.; Weathers, Rita; Hammond, Sue; Mertens, Ann C.; Donaldson, Sarah S.; Armstrong, Gregory T.; Robison, Leslie L.; Neglia, Joseph P.; Inskip, Peter D.

doi:10.1016/j.ijrobp.2012.06.006

Cited by 39 publications

(33 citation statements)

References 23 publications

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“…With adjustment for radiation dose, type of first cancer was not significantly associated with risk of subsequent glioma, meningioma, breast cancer or salivary gland cancer (10, 11, 17). There were exceptions to this general finding.…”

Section: Resultsmentioning

confidence: 92%

“…For matched casecontrol studies of cancers of the brain (10), breast (11), skin (18), and bone or soft tissue (16), doses were estimated to the tumor site for the case and corresponding location in controls. For cohort analyses involving the thyroid gland (14, 15) and salivary glands (17), an average organ dose was estimated for each individual in the cohort. Doses were reconstructed from radiotherapy records concerning the initial cancer and information regarding location of the subsequent cancer, using methods described previously (19).…”

Section: Methodsmentioning

confidence: 99%

“…Since 2005, the CCSS has published a series of analyses of treatment-related new primary cancers of the central nervous system (CNS) (10), female breast (11), thyroid gland (12–15), bone and soft tissue (16), salivary glands (17) and basal cell carcinoma (BCC) of the skin (18). These studies included detailed individual radiation dose reconstruction from radiotherapy records (19).…”

Section: Introductionmentioning

confidence: 99%

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Radiation-Related New Primary Solid Cancers in the Childhood Cancer Survivor Study: Comparative Radiation Dose Response and Modification of Treatment Effects

Inskip

Sigurdson

Veiga

et al. 2016

International Journal of Radiation Oncology*Biology*Physics

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111

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Objectives The majority of childhood cancer patients now achieve long-term survival, but the treatments that cured their malignancy often put them at risk of adverse health outcomes years later. New cancers are among the most serious of these late effects. The aims of this review are to compare and contrast radiation dose-response relationships for new solid cancers in a large cohort of childhood cancer survivors and to discuss interactions among treatment and host factors. Methods This review is based on previously published site-specific analyses for subsequent primary cancers of the brain, breast, thyroid gland, bone and soft tissue, salivary glands and skin among 12,268 five-year childhood cancer survivors in the Childhood Cancer Survivor Study. Analyses included tumor site-specific, individual radiation dose reconstruction based on radiotherapy records. Radiation-related second cancer risks were estimated using conditional logistic or Poisson regression models for excess relative risk (ERR). Results Linear dose-response relationships over a wide range of radiation dose (0–50 Gy) were seen for all cancer sites except the thyroid gland. The steepest slopes occurred for sarcoma, meningioma and non-melanoma skin cancer (ERR/Gy > 1.00), with glioma and cancers of the breast and salivary glands forming a second group (ERR/Gy=0.27–0.36). The relative risk for thyroid cancer increased up to 15–20 Gy and then decreased with increasing dose. Risk of thyroid cancer also was positively associated with chemotherapy, but the chemotherapy effect was not seen among those who also received very high doses of radiation to the thyroid. Excess risk of radiation-related breast cancer was sharply reduced among women who received 5 Gy or more to the ovaries. Conclusions Results suggest that the effect of high-dose irradiation is consistent with a linear dose-response for most organs but also reveal important organ- and host-specific differences in susceptibility and interactions between different aspects of treatment.

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Section: Resultsmentioning

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Radiation-Related New Primary Solid Cancers in the Childhood Cancer Survivor Study: Comparative Radiation Dose Response and Modification of Treatment Effects

Inskip

Sigurdson

Veiga

et al. 2016

International Journal of Radiation Oncology*Biology*Physics

Self Cite

111

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“…Of these, 57.3% received RT, with 9.3% having received a maximum dose of at least 50 Gy to the brain and 11.2% having received at least 30 Gy to the chest (December 2015 update). Excess relative risk per Gy of radiation has been calculated for SPMs in the brain, breast, thyroid gland, bone, skin, and salivary gland [48,49,50,51,52,53,54]. The results have been reviewed by Inskip and colleagues [55].…”

Section: Exposure From Treatment Modalitiesmentioning

confidence: 99%

Pediatric Exposures to Ionizing Radiation: Carcinogenic Considerations

Kutanzi

Lumen

Koturbash

et al. 2016

IJERPH

162

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Children are at a greater risk than adults of developing cancer after being exposed to ionizing radiation. Because of their developing bodies and long life expectancy post-exposure, children require specific attention in the aftermath of nuclear accidents and when radiation is used for diagnosis or treatment purposes. In this review, we discuss the carcinogenic potential of pediatric exposures to ionizing radiation from accidental, diagnostic, and therapeutic modalities. Particular emphasis is given to leukemia and thyroid cancers as consequences of accidental exposures. We further discuss the evidence of cancers that arise as a result of radiotherapy and conclude the review with a summary on the available literature on the links between computer tomography (CT) and carcinogenesis. Appropriate actions taken to mitigate or minimize the negative health effects of pediatric exposures to ionizing radiation and future considerations are discussed.

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“…Nije u potpunosti jasno koji etiološki faktori dovode do nastanka ove grupe tumora. U literaturi se dovode u vezu sa izlaganjem ultravioletnom i jonizujućem zračenju, upotrebom duvana i alkohola ili virusnom infekcijom [4,5,6]. Velike pljuvačne žlezde su parotidna, submandibularna i sublingvalna, a male su prisutne na usnama, gingivi, obrazu, palatumu, jeziku, orofarniksu, zatim u paranazalnim šupljinama i parafaringelanom prostoru.…”

Section: Uvodunclassified

Malignant tumors of the major salivary glands among the population of the city of Belgrade

Videnović¹,

Živković²,

Krasić³

et al. 2015

Praxis Med

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2 Registar za rak Srbije, Odeljenje za prevenciju i kontrolu nezaraznih bolesti, Institut za javno zdravlje Srbije "Dr Milan Jovanović -Batut", Beograd, Srbija 3 Institut za histologiju, Medicinski fakultet Priština, Kosovska Mitrovica, SrbijaMaligni tumori pljuvačnih žlezda su retka oboljenja i u najvećem broju se javljaju u velikim pljuvačnim žlez-dama. Cilj istraživanja bio je da se analizira trend incidencije malignih tumora velikih pljuvačnih žlezda kod stanovništva grada Beograda. Podaci su dobijeni iz Registra za maligne tumore centralne Srbije. Analizirani su svi slučajevi malignih tumora velikih pljuvačnih žlezda registrovani u Beogradu od 01. januara 1999. godine do 31. decembra 2010. godine. Trend kretanja i godišnji procenat promene incidencije izračunat je regresionom analizom uz pomoć tačaka spajanja (engl. joinpoint regression analysis). U ispitivanom periodu Registru je prijavljeno je 283 pacijenta (168 muškaraca i 115 žena) sa malignim tumorima velikih pljuvačnih žlezda. Standardizovana stopa incidencije svih tumora u ispitivanom periodu, za oba pola, bila je 0,87/100,000 stanovnika, odnosno 1,13 za muškarace i 0,67 za žene. Standardizovana stopa incidence se uvećavala sa godišnjim procentom promene od 6,4% kod oba pola (p<0,001). Rezultati su pokazali konstantno povećanje trenda incidencije malignih tumora velikih pljuvačnih žlezda kod stanovništva grada Beogradu između 1999. i 2010. godine.Ključne reči: pljuvačne žlezde, tumori, incidencija UVODMaligni tumori pljuvačnih žlezda su retke i verovatno najsloženije neoplazme u ljudskoj populaciji. Za razliku od ostalih malignih tumora glave i vrata, koji su najčešće planocelularni karcinomi [1,2], tumori pljuvačnih žlezda obuhvataju najmanje dvadeset različitih histopatoloških tipova [3]. Nije u potpunosti jasno koji etiološki faktori dovode do nastanka ove grupe tumora. U literaturi se dovode u vezu sa izlaganjem ultravioletnom i jonizujućem zračenju, upotrebom duvana i alkohola ili virusnom infekcijom [4,5,6]. Velike pljuvačne žlezde su parotidna, submandibularna i sublingvalna, a male su prisutne na usnama, gingivi, obrazu, palatumu, jeziku, orofarniksu, zatim u paranazalnim šupljinama i parafaringelanom prostoru. Prema podacima iz literature, najveći broj ovih tumora javlja se u velikim pljuvačnim žlezdama, naročito u parotidnoj, 64-80% svih tumora pljuvačnih žlezda [7,8]. Podaci o zastupljenosti ovih tumora u Srbiji su oskudni, tačnije, prema našem saznanju, ovo je prva studija koja daje trend u incidenciji malignih tumora pljuvačnih žlezda zasnovana na podacima iz populacionog registra za maligne tumore. CILJ RADACilj ovog istraživanja bio je da se prikaže i analizira promena incidencije malignih tumora velikih pljuvačnih žlezda kod stanovništva grada Beograda u periodu od 1999. do 2010. MATERIJAL I METODEPodaci su dobijeni iz Registra za maligne tumore centralne Srbije (Registar). Izvor informacija o obolelima su: institut za onkologiju, onkološki dispanzeri, onkološke klinike, bolničke i vanbolničke zdravstvene ustanove, patohistološke, hem...

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Risk of Salivary Gland Cancer After Childhood Cancer: A Report From the Childhood Cancer Survivor Study

Cited by 39 publications

References 23 publications

Radiation-Related New Primary Solid Cancers in the Childhood Cancer Survivor Study: Comparative Radiation Dose Response and Modification of Treatment Effects

Radiation-Related New Primary Solid Cancers in the Childhood Cancer Survivor Study: Comparative Radiation Dose Response and Modification of Treatment Effects

Pediatric Exposures to Ionizing Radiation: Carcinogenic Considerations

Malignant tumors of the major salivary glands among the population of the city of Belgrade

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