Risk of recurrent stroke in patients with sickle cell disease treated with erythrocyte transfusions

Pegelow, Charles H.; Adams, Robert J.; McKie, Virgil; Abboud, Miguel R.; Berman, Brian; Miller, Scott T.; Olivieri, Nancy F.; Vichinsky, Elliott; Wang, Winfred C.; Brambilla, Donald

doi:10.1016/s0022-3476(95)70204-0

Cited by 337 publications

(223 citation statements)

References 9 publications

Supporting

Mentioning

213

Contrasting

Unclassified

Order By: Relevance

“…African-Americans constitute 47% of the population in St. Louis City and 14% in St. Louis County [3] but only about 5% of the blood donor population in the metropolitan area is African-American. Finding ways to increase the number of minority donors in the United States is important, particularly for children with sickle cell disease (SCD) requiring monthly blood transfusion therapy for primary and secondary prevention of strokes [4,5].…”

Section: Introductionmentioning

confidence: 99%

Barriers and motivators to blood and cord blood donations in young African-American women

Grossman

Watkins

Fleming³

et al. 2005

Am. J. Hematol.

View full text Add to dashboard Cite

The primary aim of this study was to assess potential barriers and motivators to blood and cord blood donation among African-American women. A telephone survey of AfricanAmerican women, ages 18-30 years, in the St. Louis metropolitan area was performed. The survey was administered by trained telemarketing personnel using a ComputerAssisted Direct Interview (CADI) system. One hundred sixty-two women were surveyed. Common barriers to blood donation were inconvenience of donor sites (19%), fear of needles (16%), and too much time required to donate (15%). Potential motivators were increasing awareness of need for blood (43%), increasing the number of convenient donor locations (19%), and encouragement by spiritual leaders to have blood drives at their church (17%). Lack of awareness was the only identified barrier to cord blood donation. Most women surveyed (88%) indicated that they definitely or probably would donate cord blood. Strategies to increase the proportion of African-American blood and cord blood donations may include educating potential donors about the process and benefits of donation to particular patient populations and engaging church leadership in supporting blood and cord blood donations. Am.

show abstract

Section: Introductionmentioning

confidence: 99%

Barriers and motivators to blood and cord blood donations in young African-American women

Grossman

Watkins

Fleming³

et al. 2005

Am. J. Hematol.

View full text Add to dashboard Cite

show abstract

“…Chronic transfusion therapy greatly reduces the risk of recurrent stroke in children with sickle cell anemia (SCA) [2]. A major concern with this therapy is the development of transfusional iron overload, which can cause endocrinopathies, liver inflammation and fibrosis, and cardiac toxicity [3][4][5], although some of these complications appear to occur less commonly in SCA compared with thalassemia patients [6,7].…”

mentioning

confidence: 99%

Transfusional iron overload in children with sickle cell anemia on chronic transfusion therapy for secondary stroke prevention

et al. 2011

View full text Add to dashboard Cite

“…Over a 4-year period, two studies 35,36 found high rates of stroke recurrence in children with SCD of nearly 30%.…”

Section: Stroke and Cardiac Diseasesmentioning

confidence: 99%

Acidentes vasculares encefálicos em pediatria

Filho¹,

Carvalho²

2009

J. Pediatr. (Rio J.)

View full text Add to dashboard Cite

Objectives: To summarize 1) the definitions and epidemiological features of stroke in children; 2) the main risk factors that can lead to stroke in pediatrics and neonatology; 3) the main pathophysiological features involved in the genesis of brain injury in stroke; 4) the clinical manifestations and imaging diagnosis; and 5) the latest recommendations concerning the support measures, treatment, and prophylaxis of stroke in children.Sources: A review of the literature published in PubMed, EMBASE, and SciELO databases using the search terms stroke, pediatrics, and neonatology was performed, including relevant references from the chosen texts. Summary of the findings:Stroke in children are rare conditions, with incidence rates among two and eight per 100,000 children up to 14 years, and most cases show an underlying disease such as heart diseases, prothrombotic conditions, sickle-cell disease, and vascular malformations. There are no specific guidelines currently in place for the treatment of stroke in children, although central elements include support treatment, monitoring, and anticoagulation as secondary prevention in certain cases. Prognosis depends on the extent of brain damage and the underlying disease but recurrence rates are high in most cases. Conclusions:Early diagnosis of stroke in children is very important and pediatricians should be aware of the lack of specificity of the symptoms to avoid late sequelae and improve life quality.

show abstract

Risk of recurrent stroke in patients with sickle cell disease treated with erythrocyte transfusions

Cited by 337 publications

References 9 publications

Barriers and motivators to blood and cord blood donations in young African-American women

Barriers and motivators to blood and cord blood donations in young African-American women

Transfusional iron overload in children with sickle cell anemia on chronic transfusion therapy for secondary stroke prevention

Acidentes vasculares encefálicos em pediatria

Contact Info

Product

Resources

About