Risk of Recurrent Peptic Ulcer Disease in Patients Receiving Cumulative Defined Daily Dose of Nonsteroidal Anti-Inflammatory Drugs

Liang, Chih‐Ming; Yang, Shih‐Cheng; Wu, Cheng‐Kun; Li, Yuchi; Yeh, Wen‐Shuo; Tai, Wei‐Chen; Lee, Chen‐Hsiang; Yang, Ya‐Chen; Tsai, Tzu‐Hsien; Hsu, Chien‐Ning; Chuah, Seng‐Kee

doi:10.3390/jcm8101722

Cited by 7 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…22 out of 49 (44.9%) patients on NSAIDs had a recurrence of peptic ulcer, whereas only 47 out of 174 (27%) patients not on NSAIDs had a recurrence. This result is similar to another study that found not only NSAID use had increased PUD recurrence but also increasing doses of NSAIDs had increased the risk of recurrence [11].…”

Section: Resultssupporting

confidence: 90%

Risk Factors For Recurrence of Peptic Ulcer Disease: A Retrospective Study In Tertiary Care Referral Center

Alsinnari

Alqarni

Attar

et al. 2022

Preprint

View full text Add to dashboard Cite

Backgrounds: Peptic ulcer disease (PUD) is a common gastrointestinal tract disease characterized by mucosal damage secondary to pepsin and gastric acid secretion. The aim of this study was to evaluate the five-year recurrence rate for treated patients with PUD and risk factors contributing to PUD relapses.Methods: From 2016 through 2021, all patients with endoscopy-proved PUD were identified by reviewing medical records (Best-Care system). Possible risk factors including smoking, non-steroidal anti-inflammatory drugs (NSAIDs), aspirin, alcohol, caffeine, and steroid were analyzed by univariate analysis. Treatment outcomes, 5-year recurrence rate, and mortality rate were assessed.Results: Among 223 patients, there were 187 (83.8%), who diagnosed endoscopy-proved PUD and 36 (16.2%), who diagnosed clinical PUD. Among them, 126 (56.5%) patients were males and the mean age was 62±2 years. The five years recurrence rate of PUD was 30.9%. There was no significant difference in the recurrence rate between the duodenal ulcer (33.3%) and the gastric ulcer (28.8%). By univariate analysis, the use of steroid and NSAID and H. pylori infection were potential risk factors for PUD (P < 0.005). The common complication of PUD was gastrointestinal bleeding (34.1%). Patients who had a complicated PUD were associated with a higher rate of recurrence (45.9%) compared to the uncomplicated PUD (19.2%) (P > 0.05). Conclusion: Our findings demonstrated that the five years recurrence rate of PUD was 30.9%. The use of steroid and NSAID and H. pylori infection were risk factors for recurrence of PUD. PUD places a significant burden on health care systems. Therefore, a multicenter prospective study is needed for effective management to prevent recurrence and complications of PUD.

show abstract

Section: Resultssupporting

confidence: 90%

Risk Factors For Recurrence of Peptic Ulcer Disease: A Retrospective Study In Tertiary Care Referral Center

Alsinnari

Alqarni

Attar

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…22 out of 49 (44.9%) patients on NSAIDs had a recurrence of peptic ulcers, whereas only 47 out of 174 (27%) patients not on NSAIDs had a recurrence. This result is similar to another study that found that NSAID use had increased PUD recurrence and that increasing doses of NSAIDs had increased the risk of recurrence [12]. In their study, total bare dose (cDDD), the total of allocated defined daily dose (DDD), as compared to those not taking NSAIDs, defined as cDDD of 0.…”

Section: Discussionsupporting

confidence: 86%

Risk Factors for Recurrence of Peptic Ulcer Disease: A Retrospective Study in Tertiary Care Referral Center

Alsinnari¹,

Alqarni²,

Attar³

et al. 2022

Cureus

View full text Add to dashboard Cite

Peptic ulcer disease (PUD) is a common gastrointestinal tract disease characterized by mucosal damage secondary to pepsin and gastric acid secretion. This study evaluated the five-year recurrence rate for patients with PUD and risk factors contributing to PUD relapses. MethodsFrom 2016 through 2021, all patients with endoscopy-proved PUD were identified by reviewing medical records (Best-Care system). Possible risk factors including smoking, nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, alcohol, caffeine, and steroids were analyzed by multivariate analysis. Treatment outcomes, 5-year recurrence rate, and mortality rate were assessed. ResultsAmong 223 patients, there were 187 (83.8%) diagnosed with endoscopy-proved PUD and 36 (16.2%) diagnosed with clinical PUD. Among them, 126 (56.5%) patients were males, and the mean age was 62±2 years. The five years recurrence rate of PUD was 30.9%. There was no significant difference in the recurrence rate between the duodenal ulcer (33.3%) and the gastric ulcer (28.8%). By univariate analysis, the use of steroids and NSAID and Helicobacter pylori (H. pylori) infection were potential risk factors for PUD (P < 0.005). The common complication of PUD was gastrointestinal bleeding (34.1%). Patients who had a complicated PUD were associated with a higher rate of recurrence (45.9%) compared to the uncomplicated PUD (19.2%) (P > 0.05). ConclusionOur findings demonstrated that the five years recurrence rate of PUD was 30.9%. The use of steroids and NSAID and H. pylori infection were risk factors for recurrence of PUD. PUD places a significant burden on health care systems. Therefore, a multicenter prospective study is needed for effective management to prevent recurrence and complications of PUD.

show abstract

“…The greatest benefit of eradication was shown in the group of patients prior to starting long-term NSAIDs treatment, whereas in those already treated, the risk of developing peptic ulcer disease was comparable to that of patients not subjected to eradication [ 50 ]. Nevertheless, in recent years, eradication has also been shown to reduce the risk of ulcer recurrence in NSAIDs-treated patients [ 51 ]. Therefore, eradication is indicated in patients with a history of gastric and duodenal ulcers and using NSAIDs.…”

Section: Indications For Helicobacter Pylori Testingmentioning

confidence: 99%

Diagnostic and therapeutic recommendations on Helicobacter pylori infection. Recommendations of the Working Group of the Polish Society of Gastroenterology

Jaroń,

Pietrzak,

Daniluk

et al. 2023

View full text Add to dashboard Cite

Helicobacter pylori remains a major health problem worldwide, causing considerable morbidity and mortality due to peptic ulcer disease and gastric cancer. These guidelines constitute an update of the previous “Recommendations on the diagnosis and management of Helicobacter pylori infection” issued in 2014. They have been developed by a Task Force organized by the Governing Board of the Polish Society of Gastroenterology. They discuss, with particular emphasis on new scientific data covering papers published since 2014: the epidemiology, clinical presentation, diagnostic principles and criteria for the diagnosis, and recommendations for the treatment of H. pylori infection. The guidelines in particular determine which patients need to be tested and treated for infection. The Task Force also discussed recommended treatment algorithms. Accordingly, a combination of available evidence and consensus-based expert opinion were used to develop these best practice advice statements. It is worth noting that guidelines are not mandatory to implement but they offer advice for pragmatic, relevant and achievable diagnostic and treatment pathways based on established key treatment principles and using local knowledge and available resources to guide regional practice.

show abstract

Risk of Recurrent Peptic Ulcer Disease in Patients Receiving Cumulative Defined Daily Dose of Nonsteroidal Anti-Inflammatory Drugs

Cited by 7 publications

References 29 publications

Risk Factors For Recurrence of Peptic Ulcer Disease: A Retrospective Study In Tertiary Care Referral Center

Risk Factors For Recurrence of Peptic Ulcer Disease: A Retrospective Study In Tertiary Care Referral Center

Risk Factors for Recurrence of Peptic Ulcer Disease: A Retrospective Study in Tertiary Care Referral Center

Diagnostic and therapeutic recommendations on Helicobacter pylori infection. Recommendations of the Working Group of the Polish Society of Gastroenterology

Contact Info

Product

Resources

About