Risk of Recurrence in Patients With Surgically Resected Stage I Non-small Cell Lung Carcinomaa

Poleri, Claudia; Morero, José Luis; Nieva, Beatriz; Vázquez, María Fernanda; Rodríguez, Cristina; Titto, Ernesto de; Rosenberg, M

doi:10.1378/chest.123.6.1858

Cited by 82 publications

(66 citation statements)

References 24 publications

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“…Although one small study showed that high bcl-2 expression adversely affects prognosis (24), several other well-done studies suggest that bcl-2 is an independent prognostic marker of improved survival (25 -27), a finding that seems counterintuitive.…”

Section: Resultsmentioning

confidence: 99%

Prognostic Implications of Cell Cycle, Apoptosis, and Angiogenesis Biomarkers in Non–Small Cell Lung Cancer: A Review

Singhal¹,

Vachani

Antin‐Ozerkis

et al. 2005

Clinical Cancer Research

267

231

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Lung cancer is the leading cause of cancer death in the U.S. with survival restricted to a subset of those patients able to undergo surgical resection. However, even with surgery, recurrence rates range from 30% to 60%, depending on the pathologic stage. With the advent of partially effective, but potentially toxic adjuvant chemotherapy, it has become increasingly important to discover biomarkers that will identify those patients who have the highest likelihood of recurrence and who thus might benefit most from adjuvant chemotherapy. Hundreds of papers have appeared over the past several decades proposing a variety of molecular markers or proteins that may have prognostic significance in non^small cell lung cancer. This review analyzes the largest and most rigorous of these studies with the aim of compiling the most important prognostic markers in early stage non^small cell lung cancer. In this review, we focused on biomarkers primarily involved in one of three major pathways: cell cycle regulation, apoptosis, and angiogenesis. Although no single marker has yet been shown to be perfect in predicting patient outcome, a profile based on the best of these markers may prove useful in directing patient therapy. The markers with the strongest evidence as independent predictors of patient outcome include cyclin E, cyclin B1, p21, p27, p16, survivin, collagen XVIII, and vascular endothelial cell growth factor.

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Section: Resultsmentioning

confidence: 99%

Prognostic Implications of Cell Cycle, Apoptosis, and Angiogenesis Biomarkers in Non–Small Cell Lung Cancer: A Review

Singhal¹,

Vachani

Antin‐Ozerkis

et al. 2005

Clinical Cancer Research

267

231

View full text Add to dashboard Cite

show abstract

“…The total study sample size of 54 studies was 8522 with a mean of 158 (range, 45-535 patients). 23 cohorts (Pezzella et al, 1993;Fontanini et al, 1995;Fontanini et al, 1996;O'Neill et al, 1996;Apolinario et al, 1997;Koukourakis et al, 1997;Pastorino et al, 1997;Fontanini et al, 1998;Cox et al, 2000;Moldvay et al, 2000;Nguyen et al, 2000;Cox et al, 2001;Laudanski et al, 2001;Rigau et al, 2002;Swinson et al, 2002;Grossi et al, 2003;Swinson et al, 2004;Fokkema et al, 2006;Yaren et al, 2006;Ludovini et al, 2008;Anagnostou et al, 2010;Grimminger et al, 2010;Karpathiou et al, 2013) evaluated patients from Europe, 12 cohorts (Ritter et al, 1995;Anton et al, 1997;Kwiatkowski et al, 1998;D'Amico et al, 1999;Mehdi et al, 1999;Carvalho et al, 2000;Han et al, 2002;Huang et al, 2003;Poleri et al, 2003;Renouf et al, 2009;Anagnostou et al, 2010;Graziano et al, 2010) from America and 21 cohorts (Ohsaki et al, 1996;Higashiyama et al, 1997;…”

Section: Study Selection and Quality Assessmentmentioning

confidence: 99%

High Expression of Bcl-2 Protein Predicts Favorable Outcome in Non-small Cell Lung Cancer: Evidence from a Systematic Review and Meta-analysis

Zhao

He²,

Gao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Background: The prognostic value of Bcl-2 protein expression in non-small cell lung cancer (NSCLC) is under debate. We therefore systematically reviewed the evidence for Bcl-2 protein effects on NSCLC survival to elucidate this issue. Materials and Methods: An electronic search in Pubmed and Embase complemented by manual searches in article references were conducted to identify eligible studies to evaluate the association between Bcl-2 protein expression and overall survival (OS) as well as disease free survival (DFS) of NSCLC patients. Combined hazard ratios (HRs) with corresponding 95% confidence intervals (95%CIs) were pooled using the random-effects model.

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“…Cancer related deaths are projected to increase to over 11 million in 2030 (World Health Organization, 2010). Lung cancer is the major cancer killer (being responsible for an estimated 1.4 million deaths in 2008) and a health care problem worldwide with an overall 5-year survival rate of less than 15% (Brescia, 2001;Poleri et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Clitocybe alexandri extract induces cell cycle arrest and apoptosis in a lung cancer cell line: Identification of phenolic acids with cytotoxic potential

et al. 2012

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Mushrooms are a possible rich source of biologically active compounds with potential for drug discovery. The aim of this work was to gain further insight into the citotoxicity mechanism of action of Clitocybe alexandri ethanolic extract against a lung cancer cell line (NCI-H460 cells). The effects on cell cycle profile and levels of apoptosis were evaluated by flow cytometry, and the effect on the expression levels of proteins related to cellular apoptosis was also investigated by Western blot. The extract was characterized regarding its phenolic composition by HPLC-DAD, and the identified compounds were studied regarding their growth inhibitory activity, by sulforhodamine B (SRB) assay. The effect of individual or combined compounds on viable cell number was also evaluated using the Trypan blue exclusion assay. It was observed that the Clitocybe alexandri extract induced an S-phase cell cycle arrest and increased the percentage of apoptotic cells. In addition, treatment with the GI 50 concentration (concentration that was able to cause 50% of cell growth inhibition; 24.8 µg/ml) for 48h caused an increase in the levels of wt p53, cleaved caspase-3 and cleaved poly (ADPribose) polymerase (PARP). The main components identified in this extract were protocatechuic, p-hydroxybenzoic and cinnamic acids. Cinnamic acid was found to be the most potent compound regarding cell growth inhibition. Nevertheless, it was verified that the concomitant use of the individual compounds provided the strongest decrease in viable cell number. Overall, we found evidence for alterations in cell cycle and apoptosis, involving p53 and caspase-3. Furthermore, our data suggests that the phenolic acids identified in the extract are at least partially responsible for the cytotoxicity induced by this mushroom extract.

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Risk of Recurrence in Patients With Surgically Resected Stage I Non-small Cell Lung Carcinomaa

Cited by 82 publications

References 24 publications

Prognostic Implications of Cell Cycle, Apoptosis, and Angiogenesis Biomarkers in Non–Small Cell Lung Cancer: A Review

Prognostic Implications of Cell Cycle, Apoptosis, and Angiogenesis Biomarkers in Non–Small Cell Lung Cancer: A Review

High Expression of Bcl-2 Protein Predicts Favorable Outcome in Non-small Cell Lung Cancer: Evidence from a Systematic Review and Meta-analysis

Clitocybe alexandri extract induces cell cycle arrest and apoptosis in a lung cancer cell line: Identification of phenolic acids with cytotoxic potential

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