Risk of preterm delivery and hypertensive disorders of pregnancy in relation to maternal co‐morbid mood and migraine disorders during pregnancy

Abstract

Summary We evaluated risks of preterm delivery and hypertensive disorders of pregnancy among pregnant women with mood and migraine disorders. We used data from a cohort study of 3,432 pregnant women. Maternal pre-gestational or early pregnancy (before 20 weeks gestational) mood disorder and pre-gestational migraine diagnoses were ascertained from in-person interview and medical record review. We fitted generalized linear models to derive risk ratios (RR) and 95% confidence intervals (CI) of preterm delivery and hypertensive disorders of pregnancy for women with isolated mood, isolated migraine, and comorbid mood-migraine disorders, respectively. Reported RRs were adjusted for maternal age, race/ethnicity, marital status, parity, smoking status, chronic hypertension or pre-existing diabetes mellitus, and pre-pregnancy body mass index. Women without mood or migraine disorders were defined as the reference group. The risks for preterm delivery and hypertensive disorders of pregnancy were more consistently elevated among women with comorbid mood-migraine disorders than among women with isolated mood or migraine disorder. Women with comorbid disorders were almost twice as likely to deliver preterm (adjusted RR=1.87, 95% CI 1.05–3.34) compared with the referent group. There was no clear evidence of increased risks of preterm delivery and its subtypes with isolated migraine disorder. Women with mood disorder had elevated risks of preeclampsia (adjusted RR=3.57, 95% CI 1.83–6.99). Our results suggest an association between isolated migraine disorder and pregnancy-induced hypertension (adjusted RR=1.42, 95% CI 1.00–2.01). This is the first study examining perinatal outcomes in women with comorbid mood-migraine disorders. Pregnant women with a history of migraine may benefit from depression screening during prenatal care, and vigilant monitoring, especially for women with comorbid mood-migraine disorders.

Mediators of Adverse Birth Outcomes Among Socially Disadvantaged Women

“…For example, women from low SES backgrounds and those who are unmarried (not living with a partner) appear to be more likely to experience maternal health conditions in pregnancy, which may contribute to their increased risk of delivering lower birth weight and/or lower gestational age infants. [54][55][56][57][58][59] The presence of significant effects here by both social disadvantage and health conditions in pregnancy reflect this dual layering of stress sources and the adverse implications for birth outcomes. As noted, cumulative stress models point to dysregulatory cascades across physiological systems, transferring effects of stress to birth outcomes.…”

“…52,53 Studies have also shown that pregnancy-related health conditions and maternal health conditions in pregnancy contribute to an increased risk of adverse birth outcomes. [54][55][56][57][58][59] Using data from a prospective cohort study, we examined the pathways linking maternal social disadvantage to birth outcomes. Weathering theory posits that social disadvantage influences health outcomes through physical embodiment mechanisms as well as psychosocial and health behavior pathways.…”

Association of Serum Vitamin D with Symptoms of Depression and Anxiety in Early Pregnancy

“…1 Approximately 15%-30% of women experience mood and anxiety disorders during pregnancy. 2,3 Self-reported symptoms of antenatal mood disorders are associated with risk behaviors (e.g., smoking 4 and substance use during pregnancy 5 ), pregnancy complications (e.g., preeclampsia 6,7,8 and low birth weight 9 ), and long term adverse outcomes in the mother (e.g. poor postpartum mental health 5 ) and her offspring (e.g.…”

Histomorphometric and Histological Evaluations of the Flaxseeds Effect on Dentin Formation in Offsprings' Teeth of Diabetic and Non-Diabetic Pregnant Rats

“…or siblings) [9,11]. It has been known that diabetes that occurs during pregnancy can have severe adverse effects on fetal and neonatal outcomes.…”

“…Pregnancy has long been recognized as a state of relative insulin resistance, and those women who cannot meet the increased demands for insulin during pregnancy have been labeled as having gestational diabetes mellitus (GDM). [9] It occurs in about 2%-5% of all pregnancies and may improve or disappear after delivery. Gestational diabetes is fully treatable, but requires careful medical supervision throughout the pregnancy.…”