Risk of Occupational, Work-Related, and Somatic Morbidity Among Metallurgical Industries Workers

Masyagutova, L M; Abdrakhmanova, Elena R.; Габдулвалеева, Э Ф; Perminova, Vladislava

doi:10.25005/2074-0581-2021-23-2-280-290

2021

DOI: 10.25005/2074-0581-2021-23-2-280-290

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Risk of Occupational, Work-Related, and Somatic Morbidity Among Metallurgical Industries Workers

L M Masyagutova¹,

Elena R. Abdrakhmanova²,

Э Ф Габдулвалеева³

et al.

Abstract: Presently, occupational and work-related diseases make up a significant share of disability and mortality causes among the working-age population. However, to a greater extent, this is linked with the peculiarities of production rather than injuries at the workplace. In contemporary Russia, the significance of the problem is highlighted by the fact that up to 70% of metallurgical enterprises are the principal employer and mainstay of an entire town for the bulk of the employable population.

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2024

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Cited by 2 publications

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The relationship of polymorphisms of the SOD2, NOS3 and SIRT1 genes with hypertension in employees of the converter workshop of the ferrous metallurgy enterprise

Bereza,

Shaikhova,

Amromina

et al. 2024

Med. tr. prom. èkol.

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Workers employed in ferrous metallurgy enterprises are affected by various oxidants, which lead to increased formation of free radicals, suppression of the antioxidant system, initiation of oxidative stress and the development of diseases characterized by high blood pressure. In this regard, the identification of polymorphisms of genes encoding enzymes that are associated with the formation and neutralization of free radicals is an important task of personalized medicine. The study aims to explore the relationship of polymorphisms rs4880 (SOD2), rs1799983 (NOS3) and rs7069102 (SIRT1) with hypertension in workers of the converter workshop. To conduct the research the authors used data from periodic medical examinations of men aged 30 to 59 years, including 116 employees of the converter shop and 169 representatives of administrative and managerial personnel (comparison group). Subsequently, we divided each group according to the principle of the presence or absence of a diagnosis of "hypertensive heart disease" (I11 according to ICD-10), established or confirmed during a periodic medical examination. DNA was isolated from peripheral blood using the Lumiere kit for the isolation of genomic DNA from whole blood and literal epithelium (Lumiprobe, Russia) in accordance with the manufacturer's instructions. The scientists performed genotyping using the optical PCR system with real-time optical detection QuantStudio 3 (Thermo Fisher, USA) and ready-made commercial sets "SNP-Screen" (Syntol, Russia). The ratio of the chances of developing hypertension in the personnel of the converter shop was increased in carriers of mutant genotypes of the SOD2 (TT) gene. Also, the values of blood pressure, total cholesterol and glucose levels were higher in carriers of the mutant TT genotype of the SOD2 gene compared with CC/CT, but only in the group of converter shop workers with hypertension. In addition, in the comparison group with hypertension, systolic and diastolic blood pressure significantly differed, the values of which were higher in carriers of the mutant GG genotype of the SIRT1 gene. Presumably, an excess of superoxide anion in the TT genotype of the SOD2 gene, together with exposure to harmful environmental factors, may contribute to the development of cardiovascular diseases in workers of the converter workshop. Ethics. The study was approved in accordance with Protocol No. 1 dated 02/26/2021 and the conclusion of the Local Ethics Committee of the Federal Budgetary Institution of Science "Yekaterinburg Medical Scientific Center for the Prevention and Health Protection of Industrial Workers" of Rospotrebnadzor.

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The relationship of polymorphisms of the SOD2, NOS3 and SIRT1 genes with hypertension in employees of the converter workshop of the ferrous metallurgy enterprise

Bereza,

Shaikhova,

Amromina

et al. 2024

Med. tr. prom. èkol.

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On the Databases of Protein Biomarkers of Human Exposure to Environmental Hazards: A Literature Review

Gizzatullina,

Chemezov

2024

PH&LE

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Introduction: Both environmental and occupational exposure to hazardous chemicals is a public health challenge since it can induce oxidative stress, lipid peroxidation, and protein modifications. Creation of a database linking work-related risk factors and adverse human health outcomes based on protein biomarkers will contribute to the development of effective preventive and therapeutic approaches. Objective: To conduct a systematic review of literature to identify databases containing information about human protein biomarkers of exposure to environmental risk factors. Materials and methods: We examined Russian and English-language publications containing information about existing protein biomarker databases issued in 2003–2023 and found in Elibary.ru, PubMed, Google Scholar, Scopus, and Research Gate using the following keywords: database, adverse effect, biomarkers, proteins, and occupational environment. Forty of 300 papers initially selected contained systematized data of research aimed at identifying biomarkers of occupational exposures and were therefore chosen for the review. Results: Eight information sources have been found to match our search criteria. We have established that the databases are divided into two types by availability and accessibility of the information of interest. Type I databases contain research findings related to the impact of occupational exposures on the content of biomarkers (proteins) but have limited access. Type II databases are open to access, but they do not contain direct information about protein biomarkers associated with occupational exposures. Conclusion: The existing databases either contain unsystematized data on protein biomarkers of adverse human health effects or are closed to access. Thus, the task of creating such publicly available information sources deems relevant.

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Risk of Occupational, Work-Related, and Somatic Morbidity Among Metallurgical Industries Workers

Cited by 2 publications

References 14 publications

The relationship of polymorphisms of the SOD2, NOS3 and SIRT1 genes with hypertension in employees of the converter workshop of the ferrous metallurgy enterprise

The relationship of polymorphisms of the SOD2, NOS3 and SIRT1 genes with hypertension in employees of the converter workshop of the ferrous metallurgy enterprise

On the Databases of Protein Biomarkers of Human Exposure to Environmental Hazards: A Literature Review

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