Risk of obstructive sleep apnea after treatment of head and neck squamous cell carcinoma: a cross-sectional study

Gavidia, Ronald; Dunietz, Galit Levi; O’Brien, Louise M.; Schütz, Sonja G.; Spector, Matthew E.; Swiecicki, Paul; Chervin, Ronald D.

doi:10.5664/jcsm.9954

Cited by 4 publications

(8 citation statements)

References 31 publications

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“…In contrast however, Huppertz et al found that patients with small cancers had a higher risk for OSA [ 23 ]. Other studies found no association [ 16 , 20 , 22 , 32 ]. Also, type of tumor treatment, especially the involvement of radiotherapy might be associated with OSA after treatment.…”

Section: Discussionmentioning

confidence: 93%

“…Fourth, small sample sizes may have caused atypical sampling. To our knowledge, only three studies on this subject have included over 50 participants [ 17 , 22 , 33 ], of which only the one performed by Loth et al was a prospective study with PSG registration in all participants [ 17 ]. In this study, 51 participants were included with stage III-IV oropharyngeal cancer treated with CRT or surgery combined with (C)RT.…”

Section: Discussionmentioning

confidence: 99%

“…Thirteen participants (25%) had an AHI greater than 10 events/hour. Another study with a large sample was that of Gavidia et al [ 22 ]. They included 67 patients with HNC at least one year after treatment but did not perform PSG in all participants.…”

Section: Discussionmentioning

confidence: 99%

“…Also, type of tumor treatment, especially the involvement of radiotherapy might be associated with OSA after treatment. However, also because of small sample sizes results were inconclusive [ 17 , 19 , 21 , 22 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of obstructive sleep apnea after treatment for advanced T-stage head and neck cancer

Karsten,

Rijken,

Toprak

et al. 2024

Eur Arch Otorhinolaryngol

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Purpose Treatment of head and neck cancer (HNC) may lead to obstructive sleep apnea (OSA), but conclusive results on the prevalence of OSA are lacking. The objective of this study is to investigate the prevalence of OSA in a cohort of patients treated for advanced T-stage HNC. Methods A cross-sectional study was conducted in two tertiary cancer care centers including patients at least 1 year after treatment with curative intent with surgery and/or (chemo)radiotherapy ((C)RT) for advanced T-staged (T3-4) cancer of the oral cavity, oropharynx, hypopharynx, or larynx. A polysomnography (PSG) was performed in all participants. OSA was defined as an apnea–hypopnea index (AHI) of 15 events/h or higher or an AHI of 5 events/h and higher with OSA related symptoms, such as sleeping problems, daytime dysfunction and/or cardiac/metabolic comorbidities collected through file review and questionnaires. Results Of the 67 participants, 48 (72%, 95% CI 59–82%) were diagnosed with OSA. Possible risk factors are male gender, higher BMI, greater neck circumference, more nicotine pack years, cardiometabolic comorbidities, use of medication with sleepiness as side effect, present tonsils, lower T-stage (T3 vs. T4 stage), higher AJCC stage and a HPV-negative tumor. Conclusion In this population of advanced T-stage HNC patients, the prevalence of OSA was 72%, which is considerably higher than in the general population (2–50%). Given the high prevalence, screening of this entire subgroup for OSA may be indicated. Future studies to identify high risk factors and develop an OSA screening protocol are needed.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Prevalence of obstructive sleep apnea after treatment for advanced T-stage head and neck cancer

Karsten,

Rijken,

Toprak

et al. 2024

Eur Arch Otorhinolaryngol

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“…While it is well-established that oromaxillofacial surgery (OMFS) provides various surgical modalities for treating OSA both in adults and children; a new aspect is emerging regarding the possibility that some of the surgeries from the OMFS domain are also causing OSA. The latest studies are suggesting that surgical treatment in the head and neck region for causes other than OSA could possibly have a major impact on the emergence of newly developed OSA [ 6 , 7 , 8 , 9 , 10 , 11 ]. On one hand, there are oncological surgeries where indications for surgery are of vital importance, but due to tissue loss and reconstruction, they consequently cause anatomical changes and abnormalities.…”

Section: Introductionmentioning

confidence: 99%

Oromaxillofacial Surgery: Both a Treatment and a Possible Cause of Obstructive Sleep Apnea—A Narrative Review

Martinović

Tokic

Puizina-Mladinic

et al. 2023

Life

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Obstructive sleep apnea (OSA) is a chronic, sleep-related breathing disorder. It is characterized by a nocturnal periodic decrease or complete stop in airflow due to partial or total collapse of the oropharyngeal tract. Surgical treatment of OSA is constantly evolving and improving, especially with the implementation of new technologies, and this is needed because of the very heterogeneous reasons for OSA due to the multiple sites of potential airway obstruction. Moreover, all of these surgical methods have advantages and disadvantages; hence, patients should be approached individually, and surgical therapies should be chosen carefully. Furthermore, while it is well-established that oromaxillofacial surgery (OMFS) provides various surgical modalities for treating OSA both in adults and children, a new aspect is emerging regarding the possibility that some of the surgeries from the OMFS domain are also causing OSA. The latest studies are suggesting that surgical treatment in the head and neck region for causes other than OSA could possibly have a major impact on the emergence of newly developed OSA, and this issue is still very scarcely mentioned in the literature. Both oncology, traumatology, and orthognathic surgeries could be potential risk factors for developing OSA. This is an important subject, and this review will focus on both the possibilities of OMFS treatments for OSA and on the OMFS treatments for other causes that could possibly be triggering OSA.

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Obstructive sleep apnea and cancer: epidemiology, pathophysiology, and clinical aspects

CASTROGIOVANNI,

MODICA,

AMATA

et al. 2024

Minerva Respir Med

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Risk of obstructive sleep apnea after treatment of head and neck squamous cell carcinoma: a cross-sectional study

Cited by 4 publications

References 31 publications

Prevalence of obstructive sleep apnea after treatment for advanced T-stage head and neck cancer

Prevalence of obstructive sleep apnea after treatment for advanced T-stage head and neck cancer

Oromaxillofacial Surgery: Both a Treatment and a Possible Cause of Obstructive Sleep Apnea—A Narrative Review

Obstructive sleep apnea and cancer: epidemiology, pathophysiology, and clinical aspects

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