Risk of noninsulin dependent diabetes mellitus conferred by obesity and central adiposity in different ethnic groups: A comparative analysis between Asian Indians, Mexican Americans and Whites

Ramachandran, Ambady; Snehalatha, Chamukuttan; Viswanathan, Vijay; Viswanathan, M; Haffner, Steven M.

doi:10.1016/s0168-8227(97)00040-5

Cited by 143 publications

(116 citation statements)

References 15 publications

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“…Lean Asian Indians had WHR values similar to the Mexican Americans with higher rates of BMI [26]. Prevalence of diabetes in age adjusted ranges of WHR did not differ significantly between the two groups [26]. This could indicate that Asian Indians have a predisposition to deposit abdominal fat which could be one of the risk factors contributing to the high prevalence of diabetes.…”

Section: Discussionmentioning

confidence: 80%

“…Studies in India had shown that central obesity was more strongly associated with glucose intolerance than generalised obesity [6,7,25]. Lean Asian Indians had WHR values similar to the Mexican Americans with higher rates of BMI [26]. Prevalence of diabetes in age adjusted ranges of WHR did not differ significantly between the two groups [26].…”

Section: Discussionmentioning

confidence: 86%

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High prevalence of diabetes and impaired glucose tolerance in India: National Urban Diabetes Survey

et al. 2001

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 86%

High prevalence of diabetes and impaired glucose tolerance in India: National Urban Diabetes Survey

et al. 2001

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“…The Asian Indians have shown to be the most dominating of all the ethnic groups in India as they were observed to have a greater waist to hip circumference and waist to hip ratio [5] together with several other distinctive features apparent for diabetes in the Asian population [6]. The "Asian Indian Phenotype" has also shown abnormalities in their biochemical parameters for irregularities in lipid profiles and was predicted to be at a higher increased risk of T2DM [7] in which genetic susceptibility showed to play a crucial role [8].…”

Section: Introductionmentioning

confidence: 99%

Inconsistent Lipid Profiles Exhibited Among the Diabetic Asian Indians of India and Trinidad–a Comparative Study

Nayak

Geetha

2016

Int J Pharm Pharm Sci

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Objective: This was an cross-sectional observational study wherein clinical parameters were compared between the population of two countries like India and Trinidad. Methods:One hundred and six diabetic and 100 healthy individuals from Dakshina Kannada District of India were chosen and compared with 106 Type 2 diabetic and 100 healthy individuals of Trinidad. Along with anthropometric variables and blood pressure, blood samples were collected from the subjects aged above 35years of both genders who would fit with the inclusion criteria. Total cholesterol, triglyceride, VLDL, LDL and sugar levels were estimated from the blood samples collected.Results: Though both the study population were of similar BMI, we found considerable higher values from the baseline among the systolic pressure, total cholesterol and fasting blood glucose level in both the countries. Though the normal study population showed a small change in the mean values, most of the difference was not statistically significant. We found that Indian diabetic population had a higher risk of future complication of diabetes with significantly higher LDL (p=0.002) and systolic pressure (p=0.000). Conclusion:This study shows important difference among biochemical parameters and other risk factors in the Asian phenotypic races with countries like India and Trinidad. The data also showed that Indian diabetic population are at higher risk of developing complications when compared to Trinidadians.

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“…This is part of the so-called 'Asian Indian Phenotype', the other features of which include increased insulin resistance and high prevalence of diabetes which are associated with excess central, but not generalized, obesity (McKeigue et al, 1991;Ramachandran et al, 1997;Mohan et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Dietary carbohydrates, glycemic load and serum high-density lipoprotein cholesterol concentrations among South Indian adults

et al. 2007

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Objective: To examine the relationship between dietary carbohydrates, glycemic load and high-density lipoprotein cholesterol (HDL-C) concentrations in Asian Indians, a high-risk group for diabetes and premature coronary artery disease. Subjects/methods: The study population comprised of 2043 individuals aged X20 years randomly selected from Chennai Urban Rural Epidemiological Study (CURES), an ongoing population-based study on a representative population of Chennai (formerly Madras) city in southern India. Participants with self-reported history of diabetes or heart disease or on drug therapy for dyslipidemia were excluded from the study. Dietary carbohydrates, glycemic index and glycemic load were assessed using a validated interviewer administered semiquantitative Food Frequency Questionnaire (FFQ). Results: Both dietary glycemic load (Po0.0001) and total dietary carbohydrate intake (Po0.001) were significantly associated with higher serum triglyceride levels and lower serum HDL-C levels. For the lowest to highest quintile of glycemic load, the multivariate-adjusted mean HDL-C values were 44.1 mg per 100 ml and 41.2 mg per 100 ml (6.6% difference, P for trendo0.001), while for total carbohydrate it was less (5% difference, P for trend ¼ 0.016). The pattern of decrease in HDL-C for the lowest to highest quintile of glycemic load was more pronounced among men (1st vs 5th quintile: adjusted HDL-C: 4.3 mg per 100 ml decrease (10.3%)) than women (1st vs 5th quintile: adjusted HDL-C: 3.2 mg per 100 ml decrease (6.9%)). Conclusion: Our findings indicate that both total carbohydrates and dietary glycemic load intake are inversely associated with plasma HDL-C concentrations among Asian Indians, with dietary glycemic load having a stronger association.

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Risk of noninsulin dependent diabetes mellitus conferred by obesity and central adiposity in different ethnic groups: A comparative analysis between Asian Indians, Mexican Americans and Whites

Cited by 143 publications

References 15 publications

High prevalence of diabetes and impaired glucose tolerance in India: National Urban Diabetes Survey

High prevalence of diabetes and impaired glucose tolerance in India: National Urban Diabetes Survey

Inconsistent Lipid Profiles Exhibited Among the Diabetic Asian Indians of India and Trinidad–a Comparative Study

Dietary carbohydrates, glycemic load and serum high-density lipoprotein cholesterol concentrations among South Indian adults

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