Risk of Malignancy in Patients with Asthma-COPD Overlap Compared to Patients with COPD without Asthma

Bonnesen, Barbara; Sivapalan, Pradeesh; Jordan, Alexander; Pedersen, Jacob; Bergsøe, Christina Marisa; Eklöf, Josefin; Toennesen, Louise Lindhardt; Jensen, Sidse Graff; Naqibullah, Matiullah; Saghir, Zaigham

doi:10.3390/biomedicines10071463

Cited by 4 publications

(6 citation statements)

References 33 publications

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“…Their risk for any cancer diagnosis was evaluated within the following two years. Results showed that there was no association between asthma-COPD overlap and cancer, and that ICS use did not seem to modify the risk for malignancy [9].…”

Section: Cancer Risk In Patients With Asthma-copd Overlapmentioning

confidence: 90%

“…B onnesen et al . [ 9 ] (Copenhagen, Denmark) aimed to determine whether asthma was associated with an increased risk of cancer among COPD patients and the role of ICS as anti-inflammatory agents. A total of 50 897 COPD patients from Danish registries were included in the study and separated into two groups: COPD without asthma, and COPD with concomitant asthma (based on the diagnosis of a respiratory medicine physician).…”

Section: Group 101: Clinical Problemsmentioning

confidence: 99%

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ERS International Congress 2022: highlights from the Respiratory Clinical Care and Physiology Assembly

et al. 2023

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It is a challenge to keep abreast of all the clinical and scientific advances in the field of respiratory medicine. This article contains an overview of laboratory-based science, clinical trials and qualitative research that were presented during the 2022 European Respiratory Society International Congress within the sessions from the five groups of the Assembly 1 – Respiratory clinical care and physiology. Selected presentations are summarised from a wide range of topics: clinical problems, rehabilitation and chronic care, general practice and primary care, electronic/mobile health (e-health/m-health), clinical respiratory physiology, exercise and functional imaging.

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Section: Cancer Risk In Patients With Asthma-copd Overlapmentioning

confidence: 90%

Section: Group 101: Clinical Problemsmentioning

confidence: 99%

ERS International Congress 2022: highlights from the Respiratory Clinical Care and Physiology Assembly

et al. 2023

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“…Non-communicable diseases (NCDs) have a significant impact on global mortality, with CNCRDs like asthma and COPD being major contributors. In high-risk occupations like mining and construction, respiratory conditions are common, leading to a considerable number of deaths (10). Workers in the pharmaceutical industry may be exposed to substances that can affect their respiratory health, leading to allergies and sensitization to certain chemicals (11).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Chronic Non-Communicable Respiratory Diseases in Mosul City

Ibrahim,

Al-Nuaimy

2024

MJMHS

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Introduction: Chronic non-communicable respiratory diseases (CNCRDs) encompass a group of conditions affecting the airways and lung structures, including Chronic Obstructive Pulmonary Disease (COPD), emphysema, allergic rhinitis, asthma, pulmonary arterial hypertension, and cystic fibrosis. CNCRDs pose a significant global health challenge, resulting in approximately four million deaths annually. This study aimed to identify the prevalence and risk factors associated with CNCRDs and measure trends in the prevalence of these risk factors over time. Methods: A cross-sectional epidemiological study was conducted using data collected from primary health centers on both sides of Mosul City. The study period extended from January 1 to July 31, 2022, with information obtained from (40) primary health centers, consisting of (20) centers on the right side and (20) centers on the left side of Mosul. Results: In 2021, the City of Mosul recorded a total of 13,005 registered cases, with 5,598 cases being attributed to asthma (43%), and 7,347 cases being associated with COPD (57%). Bronchial asthma constituted 43% of cases, with 5598 patients, and the highest incidence occurred in the age group between 20-44 years. Conclusion: The prevalence of bronchial asthma and COPD among patients with CNCRDs in Mosul is alarmingly high. It emphasizes the importance of implementing preventive policies and strategies targeting modifiable risk factors for these respiratory conditions.

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“…This inflammation may induce a prothrombotic stage causing an increased risk of cardiovascular disease seen in patients with asthma [6][7][8][9][10][11]. An asthma-inflammation driven increased risk of cancer has also been proposed [12].…”

Section: Introductionmentioning

confidence: 99%

“…This inflammation may induce a prothrombotic stage causing an increased risk of cardiovascular disease seen in patients with asthma [ 6 – 11 ]. An asthma-inflammation-driven increased risk of cancer has also been proposed [ 12 ]. Randomised clinical trials have even shown that inhibition of interleukin-1β by canakinumab [ 13 ] and of tubulin by colchicine [ 14 ] reduces the risk of ischaemic heart disease, thus proving that low-grade inflammation plays a causative role in the development of ischaemic heart disease and its events.…”

Section: Introductionmentioning

confidence: 99%

Major cardiovascular events in patients with severe COPD with and without asthma: a nationwide cohort study

et al. 2022

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BackgroundChronic low-grade inflammation as in asthma may lead to a higher risk of cardiovascular events. We evaluated if patients with chronic obstructive pulmonary disease (COPD) and asthma have a higher risk of acute cardiovascular events than patients with COPD without asthma.MethodsNationwide multi-center retrospective cohort study of Danish outpatients with a specialist diagnosis of COPD with or without asthma. Patients with both COPD and asthma were propensity score matched 1: 2 to patients with COPD without asthma. The primary endpoint was severe major adverse cardiac events (MACE), defined as mortal cardiovascular events and events requiring revascularization or hospitalization.ResultsA total of 52 386 Danish patients with COPD were included, 34.7% had pre-existing cardiovascular disease, and 20.1% had asthma in addition to their COPD. Patients with pre-existing cardiovascular disease were then propensity score matched: 3690 patients with COPD and asthma versus 7236 patients with COPD without asthma. Similarly, for patients without pre-existing cardiovascular disease (6775 matched with 13 205).The risk of MACE was higher among patients with asthma and COPD versus COPD without asthma: Hazard ratio (HR): 1.25 (CI 1.13–1.39, p<0.0001) for patients with pre-existing cardiovascular disease and HR 1.22 (CI 1.06–1.41, p=0.005) for patients without pre-existing cardiovascular disease.ConclusionAmong patients with COPD, asthma as a comorbid condition is associated with substantially increased risk of cardiovascular events. The signal was an increased risk of 20–25%. Based on our study and other smaller studies, asthma can be considered a risk factor for cardiovascular events among COPD patients.

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Risk of Malignancy in Patients with Asthma-COPD Overlap Compared to Patients with COPD without Asthma

Cited by 4 publications

References 33 publications

ERS International Congress 2022: highlights from the Respiratory Clinical Care and Physiology Assembly

ERS International Congress 2022: highlights from the Respiratory Clinical Care and Physiology Assembly

Prevalence of Chronic Non-Communicable Respiratory Diseases in Mosul City

Major cardiovascular events in patients with severe COPD with and without asthma: a nationwide cohort study

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