Risk of malignancy for each Bethesda class in pediatric thyroid nodules

Norlén, Olov; Charlton, Amanda; Sarkis, Leba M.; Henwood, Anthony; Shun, Albert; Gill, Anthony J.; Delbridge, Leigh

doi:10.1016/j.jpedsurg.2014.10.046

Cited by 48 publications

(55 citation statements)

References 27 publications

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“…In fact, the 2 B I patients with differentiated thyroid carcinoma underwent surgery for clinical changes and/or risk factors. This study is one of the very few cytological reports using the Bethesda System for Reporting Thyroid Cytopathology for FNAB in pediatrics [22][23][24]. MR in each B category in our group was similar to that reported for adults 8.…”

supporting

confidence: 82%

Differentiated Thyroid Cancer in Children: Prevalence and Predictors in a Large Cohort with Thyroid Nodules Followed Prospectively

Papendieck¹,

Gruñeiro‐Papendieck²,

Venara³

et al. 2015

The Journal of Pediatrics

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supporting

confidence: 82%

Differentiated Thyroid Cancer in Children: Prevalence and Predictors in a Large Cohort with Thyroid Nodules Followed Prospectively

Papendieck¹,

Gruñeiro‐Papendieck²,

Venara³

et al. 2015

The Journal of Pediatrics

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“…The risk of malignancy for FLUS (36%) and SFN (20%) observed in our study falls within the ranges documented by other institutions, namely, 8%‐50% for AUS/FLUS and 10%‐100% for FN/SFN category. In contrast with our finding that FLUS category carried a higher malignant rate than SFN category, a greater rate of malignancy had been seen in FN/SFN rather than AUS/FLUS category in several of the aforementioned studies . It is noteworthy to mention that these previous published studies were conducted prior to the introduction of NIFTP terminology.…”

Section: Discussioncontrasting

confidence: 98%

“…There is limited data on histology‐confirmed malignancy within indeterminate categories from other institutions (Table ) . Similar to our data, all these previously published studies contained limited number of cases in each of the indeterminate categories, that is, 4‐25 cases in AUS/FLUS, 4‐19 cases in FN/SFN, and 2‐6 cases in SFM category.…”

Section: Discussionsupporting

confidence: 83%

Malignant risk of indeterminate pediatric thyroid nodules—An institutional experience

Heider

Arnold

Lew

et al. 2019

Diagnostic Cytopathology

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Background Few studies focus on pediatric thyroid nodules categorized under indeterminate diagnostic categories. The current study was conducted to assess the risk of malignancy of indeterminate pediatric thyroid nodules. Methods A search of the institutional electronic pathology database from 01/2011 to 09/2018 was performed to identify pediatric (<21 years old) thyroid nodules that were interpreted as follicular lesion of undetermined significance (FLUS), suspicious for follicular neoplasm (SFN), or suspicious for malignancy (SFM) and subsequently managed with surgery, repeat fine‐needle aspiration (FNA), or ≥ 6 months of clinical/imaging monitoring. Results of follow‐up (F/U) surgical resections and repeat FNA/Afirma tests, and clinical and radiologic data were collected. Results We identified 46 cases from 42 patients (11‐20 years old, 33 females and 9 males), including 30 FLUS, 10 SFN, and 6 SFM. Twenty‐five FLUS, ten SFN, and six SFM cases underwent surgery. The histology revealed carcinomas in 36% of FLUS, 20% of SFN, and 100% of SFM categories; follicular adenomas in 32% of FLUS and 80% of SFN categories; and benign nodules in 32% of FLUS category. All five nonsurgically treated FLUS cases were considered benign based on the findings of repeat FNA/Afirma tests (n = 3, 3‐22 months F/U) or clinical/radiologic exams (n = 2, 8‐12 months F/U). Conclusions Based on a limited study cohort, malignancy was identified in 36%, 20%, and 100% of surgically managed pediatric thyroid nodules categorized as FLUS, SFN, and SFM, respectively; suggesting a markedly higher malignant rate than the implied malignant risk for FLUS and SFM categories in adults.

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“…There is an incremental risk of malignancy for the pediatric population within these categories, and this is consistent with most other reports in the literature. 6,[16][17][18] FNA can be an effective means for clinicians to risk stratify thyroid nodules. 6 Overall, the accuracy of the thyroid FNA was 99% in this analysis, which is slightly superior compared to previous reports of 70-95% accuracy.…”

Section: Discussionmentioning

confidence: 99%

“…4,19 In patients younger than 10 years of age, the risk of complications increases with repeat surgery. 16 Thyroid FNA has the potential to decrease the number of patients undergoing unnecessary operations while simultaneously increasing the percentage of patients with malignancy who are referred for surgery. 20,21 FNA is a highly accurate, minimally invasive procedure that can add valuable information for clinical management of patients with thyroid nodules.…”

Section: Discussionmentioning

confidence: 99%

Histologic and Clinical Follow-up of Thyroid Fine Needle Aspirates in Pediatric Patients

Partyka

Cramer

Chen

et al. 2015

Journal of the American Society of Cytopathology

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Risk of malignancy for each Bethesda class in pediatric thyroid nodules

Cited by 48 publications

References 27 publications

Differentiated Thyroid Cancer in Children: Prevalence and Predictors in a Large Cohort with Thyroid Nodules Followed Prospectively

Differentiated Thyroid Cancer in Children: Prevalence and Predictors in a Large Cohort with Thyroid Nodules Followed Prospectively

Malignant risk of indeterminate pediatric thyroid nodules—An institutional experience

Histologic and Clinical Follow-up of Thyroid Fine Needle Aspirates in Pediatric Patients

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