Risk of malignancy after augmentation cystoplasty: A systematic review

Abstract

Augmentation cystoplasty is associated with a risk of malignancy. Studies regarding carcinogenesis and surveillance strategies should be considered to develop a more efficient follow-up protocol and allow early diagnosis. Neurourol. Urodynam. 35:675-682, 2016. © 2015 Wiley Periodicals, Inc.

Long-term effectiveness and complication rates of bladder augmentation in patients with neurogenic bladder dysfunction: A systematic review

“…One small but significant concern regarding bladder augmentation is the risk of cancer in the augmented bladder. No long‐term results for the risk of bladder cancer for patients undergoing bladder augmentation as an adult have been found, in contrast to children, where this is a known complication …”

Neuropathic bladders: Investigation and treatment through their lifetime

“…There has also been concern regarding death from malignancy after bladder augmentation, which is reported to be 0-5%, 13,32 and is likely highest when gastric segments are used. 14,33 However, it is unclear whether an augmentation increases this risk or if it is the nature of the neuropathic bladder Neuropathic bladders (i.e., exstrophy, immune suppression after transplant, smoking, infection, catheterization, chronic UTIs, and bladder stones).…”

“…15,34 Unfortunately, screening with cystoscopy and urinalysis has not proven to reduce mortality. 16,32,34 Although many patients prefer to continue catheterizing per urethra, a catheterizable abdominal wall stoma can be an attractive option. If an aggressive approach to the bladder neck is required, the patients may no longer be able to catheterize per urethra.…”

Monitoring and malignancy concerns in patients with congenital bladder anomalies

“…Most of these surveillance protocols lacked sufficient prospective study and were adaptations of adult bladder cancer protocols. Recently, several comprehensive reviews on the risk of augmentation cystoplasty and bladder cancer and surveillance protocols have been published [17,18]. However, these reports include all indications for augmentation cystoplasty.…”