2012
DOI: 10.1001/2012.jama.10857
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Risk of Malignancies in Patients With Rheumatoid Arthritis Treated With Biologic Therapy

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Cited by 282 publications
(170 citation statements)
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References 103 publications
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“…According to a recent systematic review, these longerterm adverse events that have been reported in the literature occurred in individuals who had received other immunosuppressive medications before rituximab and in nonrenal patients. 40 Finally, most recent reports, including the present trial, have included only white patients, and further studies of patients from different ethnic groups are needed.…”
Section: Discussionmentioning
confidence: 97%
“…According to a recent systematic review, these longerterm adverse events that have been reported in the literature occurred in individuals who had received other immunosuppressive medications before rituximab and in nonrenal patients. 40 Finally, most recent reports, including the present trial, have included only white patients, and further studies of patients from different ethnic groups are needed.…”
Section: Discussionmentioning
confidence: 97%
“…Rare adverse effects, such as progressive multifocal leukoencephalopathy, may occur, especially with rituximab. 7 Biologics do not seem to be associated with an increased risk of cancer overall among patients with rheumatoid arthritis, 8,9 although there may be a slight increase in the risk of skin cancers. 10,11 Whether biologic use increases the risk of lymphoma beyond that associated with rheumatoid arthritis is controversial; 5,11,12 major limitations of the current data are lack of long-term follow-up and the need for very large samples because of the rarity of this event.…”
Section: What Adverse Effects Can Occur With Biologics?mentioning
confidence: 98%
“…Özellikle RA hastalar›nda yap›lan baz› çal›flmalar anti-TNF-α tedavisi alan hastalarda malignite s›kl›¤›nda art›fl bildirmifl ancak bu durum kesin olarak do¤rulanamam›fl-t›r. [1,6,20,[28][29][30] Buna karfl›n ço¤u çal›flma melanoma d›fl› cilt kanserlerinin bu ilaçlar› kullanan hastalarda artt›¤› konusunda hemfikirdir. [30][31][32][33] Bizim çal›flmam›zda 2 hastada malignite gözlendi.…”
Section: Tart›flmaunclassified
“…Öte yandan bu sitokinlerin konak savunmas›nda görev almas› baflta infeksiyon ve olas› lenfoproliferatif hastal›k geliflimi gibi istenmeyen yan etkilerin ortaya ç›kmas›na yol açabil-mektedir. [1,2] Güvenlik kayg›lar›n›n yan›s›ra biyolojik ajanlar flu an için oldukça maliyetli tedavilerdir. Bu nedenle bu ilaçlar›n kullan›m› ülkemizde de oldu¤u üzere belli koflullara tabiidir.…”
unclassified