Risk of major depressive disorder in adolescent and young adult cancer patients in Japan

Akechi, Tatsuo; Mishiro, Izumi; Fujimoto, Shinji

doi:10.1002/pon.5881

Cited by 13 publications

(16 citation statements)

References 43 publications

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“…Meta-analyses were performed to evaluate the risk of developing severe depression or a depressive disorder and the mean severity of depressive symptoms in CYACs . The specific scales used to measure depressive symptomatology are presented in eTable 3 in Supplement 1.…”

Section: Resultsmentioning

confidence: 99%

“…Incidence and RRs in CYACs and controls without cancer for severe depression or depressive disorder (A), severe anxiety or anxiety disorder (B), and psychotic disorders (C).…”

Section: Resultsmentioning

confidence: 99%

“…From 7319 results (Figure 1), we included a total of 52 studies reporting psychiatric disorders and psychological symptoms of depression, anxiety, psychotic disorders (including schizophrenia), and suicide mortality in CYACs compared with controls without cancer (eTable 2 in Supplement 1). Most studies recruited healthy, age-matched comparators as a control group, whereas 13 studies recruited siblings and 3 studies recruited parents or caregivers of patients with cancer.…”

Section: Resultsmentioning

confidence: 99%

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Lifetime Burden of Psychological Symptoms, Disorders, and Suicide Due to Cancer in Childhood, Adolescent, and Young Adult Years

et al. 2023

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ImportanceA cancer diagnosis and treatment may result in highly traumatic periods with lasting psychological consequences for children, adolescent, and young adult patients with cancer (CYACs). Early identification and management may prevent long-term psychological morbidity and suicide.ObjectiveTo analyze risk, severity, and risk factors for depression, anxiety, psychotic disorders, and suicide in CYACs and noncancer comparators.Data SourcesLiterature search of PubMed, MEDLINE, Embase, PsycINFO, CINAHL, and PubMed Central from January 1, 2000, to November 18, 2022.Study SelectionFull-length articles in peer-reviewed journals that measured and reported risk and/or severity of depression, anxiety, psychotic disorders, and suicide mortality in CYACs and a noncancer comparator group.Data Extraction and SynthesisPreferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) reporting guidelines were followed with prospective PROSPERO registration.Main Outcomes and MeasuresRisk ratios (RRs) were used for dichotomous outcomes, and standardized mean differences (SMDs) were used for continuous outcomes. SMDs were defined as follows: 0.2, small; 0.5, medium; and 0.8, large. Sources of heterogeneity and risk factors were investigated using sensitivity, subgroup, and meta-regression analyses.ResultsFrom 7319 records, 52 studies were included. Meta-analyses revealed that CYACs were at increased lifetime risk of severe symptoms or a disorder of depression (RR, 1.57; 95% CI, 1.29-1.92), anxiety (RR, 1.29; 95% CI, 1.14-1.47), and psychotic disorders (RR, 1.56; 95% CI, 1.36-1.80) relative to both matched controls and their siblings. Overall suicide mortality was not significantly elevated (RR, 1.63; 95% CI, 0.78-3.40). The mean severity of depression was found to be elevated in CYACs receiving treatment (SMD, 0.44; 95% CI, 0.13-0.74) and long-term survivors (SMD, 0.18; 95% CI, 0.02-0.33). The mean severity of anxiety was found to be elevated only during treatment (SMD, 0.16; 95% CI, 0.03-0.20).Conclusions and RelevanceFindings of this systematic review and meta-analysis suggest that CYACs may experience lasting psychological burden long into survivorship. Timely identification, preventive efforts, and psycho-oncological intervention for psychological comorbidity are recommended.

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Section: Resultsmentioning

confidence: 99%

“…Incidence and RRs in CYACs and controls without cancer for severe depression or depressive disorder (A), severe anxiety or anxiety disorder (B), and psychotic disorders (C).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Lifetime Burden of Psychological Symptoms, Disorders, and Suicide Due to Cancer in Childhood, Adolescent, and Young Adult Years

et al. 2023

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“…As for treatment status, 38.2% of the studies recruited participants who were off treatment at the assessment time. 24,25,27,30,[32][33][34][35][36]39,[42][43][44]46,47,50,53,57,60,61,65,67,68,70,79,85 Regarding study quality, only four (5.9%) 53,59,64,88 were considered of very good and 17 (25.9%) 22,25,33,38,[42][43][44]50,52,57,62,66,68,71,72,81,90 of good quality. The rest of the studies were rated as satisfactory (47%) or unsatisfactory (22.1%) (Table 1 and eTable 4).…”

Section: Study Characteristicsmentioning

confidence: 99%

Prevalence and risk of psychological distress, anxiety and depression in adolescent and young adult (AYA) cancer survivors: A systematic review and meta‐analysis

Osmani,

Hörner,

Klug

et al. 2023

Cancer Medicine

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BackgroundAdolescent and young adult (AYA) cancer survivors (CS) face unique psychosocial challenges, which may affect their mental health. However, there are inconsistencies in AYA definitions and varying prevalence data on psychological distress, anxiety, and depression. We aimed to synthesize published literature on prevalence, risk, longitudinal changes, and predictors for these outcomes and estimate pooled prevalences.MethodsWe searched for observational studies published in English before June 1 2022, in PubMed, PsycINFO, Scopus, and Web of Science. Two researchers extracted independently information on study characteristics, prevalence, and risk. The pooled prevalence (PP) of psychological distress, anxiety, and depression was estimated using random‐effects models. Geographical region, treatment status, and assessment instruments were considered in stratified meta‐analyses.ResultsSixty‐eight studies were included in the systematic review and 57 in the meta‐analyses. We estimated an overall prevalence of 32% (n = 30; 4226/15,213 AYAs; 95% CI, 23%–42%; I2 = 99%) for psychological distress, 29% for anxiety (n = 24; 2828/8751 AYAs; 95% CI, 23%–36%; I2 = 98%), and 24% (n = 35; 3428/16,638 AYAs; 95% CI, 18%–31%; I2 = 98%) for depression. The range of PP of psychological distress varied across geographical regions, treatment status, and assessment instruments. The PP of anxiety varied significantly across continents, while no variations were seen for depression. Studies found higher risks for psychological distress, anxiety, and depression in AYAs compared to older cancer survivors or cancer‐free peers.ConclusionsOur research found that one in three AYA‐CS experience psychological distress or anxiety and one in four are affected by depression, highlighting the need for specialized psychological services for AYA‐CS in oncology settings and AYA‐focused interventions.

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“…In a questionnaire survey in Japan, pain, decrease in income after a cancer diagnosis, experience of negative changes at work or school after a cancer diagnosis, and poor social support were reported to be significantly associated with psychological distress [ 14 ]. Furthermore, AYA patients with cancer in Japan have a three-fold higher risk of major depressive disorder within 6 months before and 12 months after cancer diagnosis compared with cancer-free controls [ 15 ]. A previous study found that AYA patients with cancer aged 15–24 years have a higher risk of suicide than cancer-free controls [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Mental health care use and related factors in adolescents and young adults with cancer

Hirayama¹,

Ikezawa

Okubo

et al. 2023

Support Care Cancer

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Purpose The actual state of mental health care use and related factors in adolescent and young adult (AYA) patients with cancer is not well understood in Japan. This study aimed to (1) examine the actual state of mental health care use among AYA patients with cancer and (2) describe socio-demographic and related factors associated with mental health care use. Methods We retrospectively reviewed the medical records of AYA patients with cancer aged 15–39 who first visited the National Cancer Center Hospital in Japan (NCCH) between January 2018 and December 2020. Logistic regression was used to analyze the association between social background characteristics and mental health care use. The association between the patient's course of cancer treatment and mental health care use was analyzed to help identify which patients might benefit from early mental health intervention. Results Among 1,556 patients, 945 AYA patients with cancer were registered. The median age at the time of the study was 33 years (range, 15–39 years). The prevalence of mental health care use was 18.0% (170/945). Age 15–19 years, female gender, urogenital cancer, gynecological cancer, bone or soft tissue cancer, head and neck cancer, and stage II–IV disease were associated with mental health care use. Regarding treatment, palliative treatment, chemotherapy, and hematopoietic stem cell transplantation were associated with mental health care use. Conclusion Factors associated with mental health care use were identified. Our findings potentially contribute to psychological support interventions for AYA patients with cancer.

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Risk of major depressive disorder in adolescent and young adult cancer patients in Japan

Cited by 13 publications

References 43 publications

Lifetime Burden of Psychological Symptoms, Disorders, and Suicide Due to Cancer in Childhood, Adolescent, and Young Adult Years

Lifetime Burden of Psychological Symptoms, Disorders, and Suicide Due to Cancer in Childhood, Adolescent, and Young Adult Years

Prevalence and risk of psychological distress, anxiety and depression in adolescent and young adult (AYA) cancer survivors: A systematic review and meta‐analysis

Mental health care use and related factors in adolescents and young adults with cancer

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