Risk of major comorbidities among workers with hemophilia

Abstract

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Health and quality of life of patients with haemophilia: A national study of 124 Danish men

“…Our results concerning increased prevalence of hypertension has been reported in several earlier studies of hypertension among PWH 15–17 . Other studies have found increased risk of ischemic stroke among PWH 18 and a recent study of employees in Taiwan found a 4.6‐time higher risk of haemorrhagic stroke 19 . Thus, the findings regarding differences between Danish PWH and the general population are in line with results from other studies.…”

“…[15][16][17] Other studies have found increased risk of ischemic stroke among PWH 18 and a recent study of employees in Taiwan found a 4.6-time higher risk of haemorrhagic stroke. 19 Thus, the findings regarding differences between Danish PWH and the general population are in line with results from other studies. In contrast, the lack of significant differences in other areas are surprising.…”

Health and quality of life of patients with haemophilia: A national study of 124 Danish men

“…Our results concerning increased prevalence of hypertension has been reported in several earlier studies of hypertension among PWH 15–17 . Other studies have found increased risk of ischemic stroke among PWH 18 and a recent study of employees in Taiwan found a 4.6‐time higher risk of haemorrhagic stroke 19 . Thus, the findings regarding differences between Danish PWH and the general population are in line with results from other studies.…”

“…[15][16][17] Other studies have found increased risk of ischemic stroke among PWH 18 and a recent study of employees in Taiwan found a 4.6-time higher risk of haemorrhagic stroke. 19 Thus, the findings regarding differences between Danish PWH and the general population are in line with results from other studies. In contrast, the lack of significant differences in other areas are surprising.…”

Parents Perceived Burden, Societal Behavior, and Quality of Life of Patients with Hemophilia: A Case-Study of the Children’s Hospital Multan

“…These results are aligned with a previous study by (Chu et al, 2018), who identified problems in physical health and mobility as a consequence of bleeding episodes.…”

Prevalence of selected bleeding and thrombotic events in persons with hemophilia versus the general population: A scoping review

“…There were 47 publications reporting data on the prevalence of the selected bleeding events (hemorrhagic stroke, ICH, and gastrointestinal bleeding) in persons with hemophilia. Of these, 10 publications included comparisons with the general population ( Table 1 ) [ [4] , [5] , [6] , [7] , [13] , [14] , [15] , [16] , [17] , [18] ]. Nine of these 10 studies compared the prevalence in persons with hemophilia with matched controls [ [4] , [5] , [6] , [7] , [13] , [14] , [15] , 19 ].…”

“…2016 [ 16 ] Newborns <2 wks old with HA 1998-2015 Intracranial hemorrhage Newborns with HA n = 163 5 (3.1%) Nonhemophilic children n = NR 0.04-0.11% (estimated) a Chu et al. 2018 [ 17 ] HA/B >16 y 1997-2010 Hemorrhagic stroke n, % Employed persons with hemophilia n = 400 17 (4.29%) Matched persons in the general population n = 1600 15 (0.97%) Crude HR (95% CI): 4.72 (2.94-7.59); P < .0001 Adjusted HR (95% CI): 4.60 (2.81-7.53); P < .0001 Husseinzadeh et al. 2018 [ 18 ] HA/B ≥18 y 2013-2016 Cerebral microbleeds Persons with HA n = 31 11 (35%; 95% CI, 19%-58%) Controls n = 32 8 (25%; 95% CI, 11%-47%); P = .42 HA/B, hemophilia A/B; HR, hazard ratio; NR, not reported.…”

Health and quality of life of patients with haemophilia: A national study of 124 Danish men

“…Our results concerning increased prevalence of hypertension has been reported in several earlier studies of hypertension among PWH 15–17 . Other studies have found increased risk of ischemic stroke among PWH 18 and a recent study of employees in Taiwan found a 4.6‐time higher risk of haemorrhagic stroke 19 . Thus, the findings regarding differences between Danish PWH and the general population are in line with results from other studies.…”

“…[15][16][17] Other studies have found increased risk of ischemic stroke among PWH 18 and a recent study of employees in Taiwan found a 4.6-time higher risk of haemorrhagic stroke. 19 Thus, the findings regarding differences between Danish PWH and the general population are in line with results from other studies. In contrast, the lack of significant differences in other areas are surprising.…”

Parents Perceived Burden, Societal Behavior, and Quality of Life of Patients with Hemophilia: A Case-Study of the Children’s Hospital Multan

“…These results are aligned with a previous study by (Chu et al, 2018), who identified problems in physical health and mobility as a consequence of bleeding episodes.…”

Prevalence of selected bleeding and thrombotic events in persons with hemophilia versus the general population: A scoping review

“…There were 47 publications reporting data on the prevalence of the selected bleeding events (hemorrhagic stroke, ICH, and gastrointestinal bleeding) in persons with hemophilia. Of these, 10 publications included comparisons with the general population ( Table 1 ) [ [4] , [5] , [6] , [7] , [13] , [14] , [15] , [16] , [17] , [18] ]. Nine of these 10 studies compared the prevalence in persons with hemophilia with matched controls [ [4] , [5] , [6] , [7] , [13] , [14] , [15] , 19 ].…”

“…2016 [ 16 ] Newborns <2 wks old with HA 1998-2015 Intracranial hemorrhage Newborns with HA n = 163 5 (3.1%) Nonhemophilic children n = NR 0.04-0.11% (estimated) a Chu et al. 2018 [ 17 ] HA/B >16 y 1997-2010 Hemorrhagic stroke n, % Employed persons with hemophilia n = 400 17 (4.29%) Matched persons in the general population n = 1600 15 (0.97%) Crude HR (95% CI): 4.72 (2.94-7.59); P < .0001 Adjusted HR (95% CI): 4.60 (2.81-7.53); P < .0001 Husseinzadeh et al. 2018 [ 18 ] HA/B ≥18 y 2013-2016 Cerebral microbleeds Persons with HA n = 31 11 (35%; 95% CI, 19%-58%) Controls n = 32 8 (25%; 95% CI, 11%-47%); P = .42 HA/B, hemophilia A/B; HR, hazard ratio; NR, not reported.…”

Health and quality of life of patients with haemophilia: A national study of 124 Danish men

“…Our results concerning increased prevalence of hypertension has been reported in several earlier studies of hypertension among PWH 15–17 . Other studies have found increased risk of ischemic stroke among PWH 18 and a recent study of employees in Taiwan found a 4.6‐time higher risk of haemorrhagic stroke 19 . Thus, the findings regarding differences between Danish PWH and the general population are in line with results from other studies.…”

“…[15][16][17] Other studies have found increased risk of ischemic stroke among PWH 18 and a recent study of employees in Taiwan found a 4.6-time higher risk of haemorrhagic stroke. 19 Thus, the findings regarding differences between Danish PWH and the general population are in line with results from other studies. In contrast, the lack of significant differences in other areas are surprising.…”

Parents Perceived Burden, Societal Behavior, and Quality of Life of Patients with Hemophilia: A Case-Study of the Children’s Hospital Multan

“…These results are aligned with a previous study by (Chu et al, 2018), who identified problems in physical health and mobility as a consequence of bleeding episodes.…”

Prevalence of selected bleeding and thrombotic events in persons with hemophilia versus the general population: A scoping review

“…There were 47 publications reporting data on the prevalence of the selected bleeding events (hemorrhagic stroke, ICH, and gastrointestinal bleeding) in persons with hemophilia. Of these, 10 publications included comparisons with the general population ( Table 1 ) [ [4] , [5] , [6] , [7] , [13] , [14] , [15] , [16] , [17] , [18] ]. Nine of these 10 studies compared the prevalence in persons with hemophilia with matched controls [ [4] , [5] , [6] , [7] , [13] , [14] , [15] , 19 ].…”

“…2016 [ 16 ] Newborns <2 wks old with HA 1998-2015 Intracranial hemorrhage Newborns with HA n = 163 5 (3.1%) Nonhemophilic children n = NR 0.04-0.11% (estimated) a Chu et al. 2018 [ 17 ] HA/B >16 y 1997-2010 Hemorrhagic stroke n, % Employed persons with hemophilia n = 400 17 (4.29%) Matched persons in the general population n = 1600 15 (0.97%) Crude HR (95% CI): 4.72 (2.94-7.59); P < .0001 Adjusted HR (95% CI): 4.60 (2.81-7.53); P < .0001 Husseinzadeh et al. 2018 [ 18 ] HA/B ≥18 y 2013-2016 Cerebral microbleeds Persons with HA n = 31 11 (35%; 95% CI, 19%-58%) Controls n = 32 8 (25%; 95% CI, 11%-47%); P = .42 HA/B, hemophilia A/B; HR, hazard ratio; NR, not reported.…”