Risk of liver dysfunction and non-alcoholic fatty liver diseases in people with hidradenitis suppurativa: A systematic review and meta-analysis of real-world evidences

Abstract

BackgroundTo date, evidences with high evidence-level evaluating the association between liver diseases and hidradenitis suppurativa was lacking. Given that inconsistency exists in some of the previous observational studies, evaluating the prevalence of liver diseases in HS patients could potentially serve as a reference of future guidelines for HS comorbidity screening. The aim of the current study was to evaluate potential association between hidradenitis suppurativa and liver diseases and provide integrated evidences.MethodsA search in PubMed, Web of Science and Embase based on the syntaxes ‘‘hidradenitis suppurativa’’ or ‘‘acne inversa’’ with “comorbidities”, “liver diseases”, “fatty liver” or “hepatitis” was performed. Observational studies evaluating epidemiological association between hidradenitis suppurativa and the risk of all liver diseases, including specific diseases as non-alcoholic fatty liver disease, hepatitis B, hepatitis C were targeted to be extracted in this systematic review and meta-analysis.ResultsWithin the initial 702 records, there were finally 8 real-world observational studies extracted. Results suggest that patients with HS are associated with all liver diseases (OR= 1.50; 95% CI, 1.27, 1.76), non-alcoholic fatty liver disease (OR= 1.78; 95% CI, 1.28, 2.48) and hepatitis B (OR=1.48; 95% CI, 1.12, 1.94), but not hepatitis C (OR= 1.27; 95% CI, 0.78, 2.07). HS patients were associated with significantly increased risk of liver diseases, especially the risk of non-alcoholic fatty liver disease and hepatitis B.ConclusionsClinicians should be alert to the clinical relationship while caring people with hidradenitis suppurativa and the screening of liver function should be recommended to HS patients. Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42022296034.

Blood T Helper Memory Cells: A Tool for Studying Skin Inflammation in HS?

“…As presented in Figure 5, a gene ontology enrichment analysis for human disease association demonstrated a link of the DETs detected in blood HS Th mem cells with different neurological disorders, as well as adipose-tissue-involving thermogenesis, oxidative-stress-mediated carcinogenesis, non-alcoholic fatty liver disease, and virus infection. Interestingly, depression, schizophrenia, and bipolar disorder as well as metabolic alterations and non-alcoholic fatty liver disease were demonstrated to be associated with HS [10,11,17,53,54].…”

“…Patients with HS frequently suffer from anxiety, limitations in many areas of life, including their sexual and professional lives, and stigmatization [6][7][8][9]. Furthermore, patients with HS are often affected by metabolic syndrome, nonalcoholic fatty liver disease, atherosclerosis, spondyloarthritis, inflammatory bowel disease, schizophrenia, and bipolar disorders [10][11][12][13][14][15][16][17][18]. The importance of HS arises not only from its profound negative impact on the health as well as the social and professional lives of patients but also from its strong negative socio-economic impact on society.…”

Hidradenitis suppurativa as a potential risk factor of periodontitis: a multi-center, propensity-score-matched cohort study

“…International Publisher predominant gender difference [1]. In HS patients, involvement of comorbidities in various organ system were commonly observed [2][3][4][5]. This may be attributed to the systemic inflammatory nature of HS pathogenesis.…”

Patients with hidradenitis suppurativa are associated with a high risk of cholecystitis and pancreatitis: a retrospective cohort study

“…1,2 In recent studies, gastroenterological dysfunction, including several liver diseases and gallstones, has been reported to be associated with HS. 3,4 However, current evidence regarding HS and the risk of inflammatory gastroenterological dysfunction was insufficient and was mostly limited to a cross-sectional study design. 4 Therefore, in this study, we would like to evaluate the risk of HS patients developing future cholecystitis and acute pancreatitis.…”