Risk of late aortic events after an isolated aortic valve replacement for bicuspid aortic valve stenosis with concomitant ascending aortic dilation

Girdauskas, Evaldas; Disha, Kushtrim; Raisin, Heinrich H; Secknus, Maria‐Anna; Borger, Michael A.; Kuntze, Thomas

doi:10.1093/ejcts/ezs137

Cited by 120 publications

(75 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This so called "root phenotype" has been associated with male sex, right-left cusp fusion and aortic insufficiency that may lead to a faster root and tubular ascending aorta dilatation and higher dissection (18,19).…”

Section: Bav and Aortopathy: A Close Relationshipmentioning

confidence: 99%

Bicuspid aortic valve syndrome: a multidisciplinary approach for a complex entity

et al. 2017

View full text Add to dashboard Cite

Bicuspid aortic valve (BAV) or bicuspid aortopathy is the most common congenital heart disease.It can be clinically silent and it is often identified as an incidental finding in otherwise healthy, asymptomatic patients. However, it can be dysfunctioning at birth, even requiring neonatal intervention, or, in time, lead to aortic stenosis, aortic insufficiency, and endocarditis, and also be associated with aortic aneurysm and aortic dissection. Given its prevalence and significant complications, it is estimated that BAV is responsible for more deaths and morbidity than the combined effects of all the other congenital heart defects. Pathology of BAV is still not well known and many questions are unresolved. In this manuscript we review some aspects on bicuspid aortopathy, a heterogeneous and frequent disease in which like some authors have previously described, complex gene environment are present. Further investigations and, what is more, multidisciplinary teams are needed to improve our knowledge on this really fascinating disease.

show abstract

Section: Bav and Aortopathy: A Close Relationshipmentioning

confidence: 99%

Bicuspid aortic valve syndrome: a multidisciplinary approach for a complex entity

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Aortic events after isolated AVR surgery in patients with BAV disease has become the center of discussion due to a limited number of follow-up studies addressing this issue and discordant results. 8- 13 Considering the relatively long life expectancy of BAV patients undergoing AVR surgery, not only aortic diameters but also the patient's age should be included in the decision-making process for BAV patients. Because the natural history of BAV aortopathy in the Japanese population is still unclear, and the incidence of aortic events in BAV patients might be different according to race, it is also important to know the long-term results of Japanese patients when deciding on the strategies used to treat the dilated aorta.…”

Section: Predictors Of Rapid Progression Of Aortic Diameter and Postomentioning

confidence: 99%

Valve Phenotype and Risk Factors of Aortic Dilatation After Aortic Valve Replacement in Japanese Patients With Bicuspid Aortic Valve

Kinoshita

Naito

Suzuki

et al. 2016

Circ J

View full text Add to dashboard Cite

Background:The aim of this study was to assess the risk factors for dilatation of the aorta over time in Japanese patients with bicuspid aortic valve (BAV) undergoing aortic valve replacement (AVR), focusing on the possible impact of valve fusion phenotype. Methods and Results:Of 167 BAV patients undergoing AVR (24% of overall AVR patients, n=702), 135 patients in whom surgical intervention for the aorta was not undertaken were focused on (74 had right-left fusion and 61 non-right-left fusion type). During a mean follow up of 5.2 years, aortic growth rate (mm/year) of the ascending aorta was similar between the valve phenotype. In multivariate logistic regression, the presence of aortic regurgitation > moderate was significantly associated with a rapid dilatation of the ascending aorta, defined as >0.7 mm/year (odds ratio 2.1, 95% confidence interval 1.2-3.7, P=0.03). Independent predictors of dilatation of the aorta up to more than 45 mm were: a diameter of the ascending aorta >40 mm at the time of surgery (odds ratio 3.7, 95% confidence interval 1.2-11.4, P=0.02) and length of follow up (odds ratio 1.3-increase per year, 95% confidence interval 1.0-1.5, P=0.04). Conclusions:The presence of aortic regurgitation and the ascending aorta of >40 mm at the time of surgery emerged as significant predictors of dilatation of the aorta after AVR but valve fusion phenotype was not. (Circ J 2016; 80: 1356 -1361

show abstract

“…5 In contrast, some researchers showed that AVR alone had reasonable and acceptable late outcomes for patients with a mildly or moderately dilated aorta at the time of AVR. [6][7][8] There is still great debate on the optimal management of this condition.…”

Section: Patientsmentioning

confidence: 99%

Aortic Wrapping for a Dilated Ascending Aorta in Bicuspid Aortic Stenosis

Choi

Jeong

Lee

et al. 2015

Circ J

View full text Add to dashboard Cite

Risk of late aortic events after an isolated aortic valve replacement for bicuspid aortic valve stenosis with concomitant ascending aortic dilation

Cited by 120 publications

References 21 publications

Bicuspid aortic valve syndrome: a multidisciplinary approach for a complex entity

Bicuspid aortic valve syndrome: a multidisciplinary approach for a complex entity

Valve Phenotype and Risk Factors of Aortic Dilatation After Aortic Valve Replacement in Japanese Patients With Bicuspid Aortic Valve

Aortic Wrapping for a Dilated Ascending Aorta in Bicuspid Aortic Stenosis

Contact Info

Product

Resources

About