Risk of ischemic stroke in primary aldosteronism patients

Kao, Chih-Chin; Wu, Che‐Hsiung; Lin, Yen-Hung; Chang, Chin Chen; Chen, Hsi Hsien; Wu, Mai‐Szu; Wu, Vin‐Cent; Wu, Kwan‐Dun

doi:10.1016/j.cca.2014.08.007

Cited by 9 publications

(3 citation statements)

References 44 publications

(48 reference statements)

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“…In addition, Milliez et al reported 12.9% of patients with PA had a history of stroke (4). However, Miyaji et al discovered the incidence of PA in patients with acute stroke was just 4.% (79). The reasons to underestimate this incidence of stroke in patients with PA might be due to the demographic bias and non-standard confirmatory test strategies.…”

Section: Toxic Effects Of Aldosterone On Strokementioning

confidence: 99%

Cerebro-Cardiovascular Risk, Target Organ Damage, and Treatment Outcomes in Primary Aldosteronism

Lin

Ullah

Xiong

et al. 2022

Front. Cardiovasc. Med.

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Primary aldosteronism (PA) is the most common type of endocrine hypertension, and numerous experimental and clinical evidence have verified that prolonged exposure to excess aldosterone is responsible for an increased risk of cerebro-cardiovascular events and target organ damage (TOD) in patients with PA. Therefore, focusing on restoring the toxic effects of excess aldosterone on the target organs is very important to reduce cerebro-cardiovascular events. Current evidence convincingly demonstrates that both surgical and medical treatment strategies would benefit cerebro-cardiovascular outcomes and mortality in the long term. Understanding cerebro-cardiovascular risk in PA would help clinical doctors to achieve both early diagnosis and treatment. Therefore, in this review, we will summarize the cerebro-cardiovascular risk in PA, focusing on the TOD of aldosterone, including brain, heart, vascular system, renal, adipose tissues, diabetes, and obstructive sleep apnea (OSA). Furthermore, the various treatment outcomes of adrenalectomy and medical treatment for patients with PA will also be discussed. We hope this knowledge will help improve cerebro-cardiovascular prognosis and reduce the incidence and mortality of cerebro-cardiovascular events in patients with PA.

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Section: Toxic Effects Of Aldosterone On Strokementioning

confidence: 99%

Cerebro-Cardiovascular Risk, Target Organ Damage, and Treatment Outcomes in Primary Aldosteronism

Lin

Ullah

Xiong

et al. 2022

Front. Cardiovasc. Med.

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“…Generally, cerebrovascular events occur in 10% to 20% in PA patients [ 40 ]. In 2018, the largest meta-analysis on cardiovascular events in PA patients to date, conducted by Monticone et al [ 36 ], showed that their overall risk of stroke was 2.58 times (95% CI, 1.93 to 3.45) higher than that of EH patients.…”

Section: Clinical Status Of Cerebrovascular Diseases In Primary Aldosmentioning

confidence: 99%

“…In our TAIPAI database, the incidence of stroke in PA patients was 35 cases per 1,000 person-years [ 40 ], much higher than that of the general population (3.4 to 5.2 cases per 1,000 person-years) [ 9 ]. We further found that proteinuria, a medical history of coronary artery disease (OR, 11.12; 95% CI, 3.85 to 33.50; P <0.001) and left ventricular hypertrophy (OR, 3.58; 95% CI, 1.16 to 10.80; P =0.023) were risk factors of ischemic stroke in PA patients [ 40 ]. Additionally, Satoh et al [ 45 ] identified the aldosterone-to-renin ratio as a predictor of stroke in subjects with high sodium intake.…”

Section: Other Studies Related To Cerebrovascular Diseases In Primarymentioning

confidence: 99%

Primary Aldosteronism and Cerebrovascular Diseases

Chen

Hung

et al. 2018

Endocrinol Metab

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As diagnostic techniques have advanced, primary aldosteronism (PA) has emerged as the most common cause of secondary hypertension. The excess of aldosterone caused by PA resulted in not only cardiovascular complications, including coronary artery disease, myocardial infarction, arrhythmia, and heart failure, but also cerebrovascular complications, such as stroke and transient ischemic attack. Moreover, PA is associated more closely with these conditions than is essential hypertension. In this review, we present up-to-date findings on the association between PA and cerebrovascular diseases.

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