Risk of ischemic heart disease following occupational exposure to welding fumes: a systematic review with meta-analysis

Mocevic, Emina; Kristiansen, Pernille; Bonde, Jens Peter

doi:10.1007/s00420-014-0965-2

Cited by 28 publications

(12 citation statements)

References 24 publications

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“…It is known that WFs can cause also nonmalignant lung diseases. Additionally, occupational exposure to particle and WFs has been associated with an increased risk of cardiovascular disease, and fine particles (aerodynamic diameter < 2.5 micrometer µm) seem to play a key role [6].…”

Section: Introductionmentioning

confidence: 99%

Welding Fumes, a Risk Factor for Lung Diseases

Riccelli

Goldoni

Poli

et al. 2020

IJERPH

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(1) Background: Welding fumes (WFs) are composed of fine and ultrafine particles, which may reach the distal airways and represent a risk factor for respiratory diseases. (2) Methods: In vitro and in vivo studies to understand WFs pathogenesis were selected. Epidemiological studies, original articles, review, and meta-analysis to examine solely respiratory disease in welders were included. A systematic literature search, using PubMed, National Institute for Occupational Safety and Health Technical Information Center (NIOSHTIC), and Web of Science databases, was performed. (3) Results: Dose, time of exposure, and composition of WFs affect lung injury. Inflammation, lung defense suppression, oxidative stress, DNA damage, and genotoxic effects were observed after exposure both to mild and stainless steel WFs. (4) Conclusions: The detection of lung diseases associated with specific occupational exposure is crucial as complete avoidance or reduction of the exposure is difficult to achieve. Further studies in the area of particle research may aid the understanding of mechanisms involved in welding-related lung disease and to expand knowledge in welding-related cardiovascular diseases.

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Section: Introductionmentioning

confidence: 99%

Welding Fumes, a Risk Factor for Lung Diseases

Riccelli

Goldoni

Poli

et al. 2020

IJERPH

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“…Previous reports suggested an association between welding fumes and increased risk of CVD [ 6 , 11 , 12 ]; for example, the standardized incidence ratio for acute myocardial infarction was 1.12 (95% CI 1.01–1.24) in a Danish prospective study of welders followed until 2006 [ 12 ] and the standardized mortality ratio for ischemic heart disease was 1.35 (95% CI 1.1–1.6) in a Swedish study of welders followed until 1995 [ 6 ]. However, one meta-analysis revealed that the relationship between welding fumes and CVD was not robust, since bias and confounding effects could not be ruled out [ 13 ]. Therefore, the association between occupational exposure to welding fumes and elevated CVD risk was not well established, despite of the general consensus that exposure to PM increases the risk for CVD.…”

Section: Introductionmentioning

confidence: 99%

A Cross-Sectional Study of the Cardiovascular Effects of Welding Fumes

Hedmer

Kåredal

et al. 2015

PLoS ONE

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ObjectivesOccupational exposure to particulate air pollution has been associated with an increased risk of cardiovascular disease. However, the risk to welders working today remains unclear. We aimed to elucidate the cardiovascular effects of exposure to welding fumes.MethodsIn a cross-sectional study, structured interviews and biological sampling were conducted for 101 welders and 127 controls (all non-smoking males) from southern Sweden. Personal breathing zone sampling of respirable dust was performed. Blood pressure (BP) and endothelial function (using peripheral arterial tonometry) were measured. Plasma and serum samples were collected from peripheral blood for measurement of C-reactive protein, low-density lipoprotein, homocysteine, serum amyloid A, and cytokines.ResultsWelders were exposed to 10-fold higher levels of particles than controls. Welders had significantly higher BP compared to controls, an average of 5 mm Hg higher systolic and diastolic BP (P≤0.001). IL-8 was 3.4 ng/L higher in welders (P=0.010). Years working as a welder were significantly associated with increased BP (β=0.35, 95%CI 0.13 – 0.58, P=0.0024 for systolic BP; β=0.32, 95%CI 0.16 – 0.48, P<0.001 for diastolic BP, adjusted for BMI) but exposure to respirable dust was not associated with BP. No clear associations occurred between welding and endothelial function, or other effect markers.ConclusionsA modest increase in BP was found among welders compared to controls suggesting that low-to-moderate exposure to welding fumes remains a risk factor for cardiovascular disease.

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“…However, in this study measurements of respirable dust and sampling of blood were not conducted on the same day, which may have affected the results. Welders have in earlier studies been associated with having increased risks of cardiovascular diseases, such as ischemic heart disease (Mocevic et al 2015 ) and increased blood pressure (Li et al 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Occupational exposure to particles and biomarkers of cardiovascular disease—during work and after vacation

Grahn

Broberg

Gustavsson

et al. 2022

Int Arch Occup Environ Health

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Objective Ambient particle matter is a risk factor for cardiovascular disease (CVD). However, little is known about associations between particles in occupational settings and risk of CVD. We investigated associations between occupational dust exposure and biomarkers of CVD, and potential recovery effects after vacation. Methods Personal dust exposure measurements (respirable silica, respirable dust < 4 µm, and particles of 0.1–10 µm (PM 0.1–10) were conducted once, and biological sampling were performed twice on non-smoking, male construction workers in Stockholm county, Sweden; during work and immediately after summer vacation. Linear regressions with adjustments for confounders and covariates were performed evaluating associations between occupational dust exposure and biomarkers. Paired t tests were performed evaluating changes before and after vacation. Results Sixty-five workers participated. Homocysteine concentrations were significantly higher with increasing concentrations (mg/m3) of respirable silica, respirable dust, and PM 0.1–10, and pulse rate with higher levels of respirable dust and dust of PM 0.1–10. Homocysteine levels were also positively correlated to number of years of dust exposure, as were low-density lipoprotein (LDL) levels. A clear recovery effect was present for LDL after vacation, but not for homocysteine. Conclusions Occupational dust exposure was associated with some CVD risk markers, even at mean exposure concentrations below the Swedish occupational exposure limits for respirable silica and respirable dust, respectively. Vacation resulted in recovery for some risk markers. However, the change of the homocysteine and LDL levels suggest a long-term effect. Reduction of occupational exposure to dust may decrease the risk of CVD among exposed workers.

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Risk of ischemic heart disease following occupational exposure to welding fumes: a systematic review with meta-analysis

Abstract: Several studies indicate that welding is associated with a moderately increased risk of IHD; however, bias and confounding cannot be ruled out with reasonable confidence.

Cited by 28 publications

References 24 publications

Welding Fumes, a Risk Factor for Lung Diseases

Welding Fumes, a Risk Factor for Lung Diseases

A Cross-Sectional Study of the Cardiovascular Effects of Welding Fumes

Occupational exposure to particles and biomarkers of cardiovascular disease—during work and after vacation

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