Risk of intracranial hypertension with intrauterine levonorgestrel

Friedman, Deborah I.

doi:10.1177/2042098615622316

Cited by 6 publications

(2 citation statements)

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“…Idiopathic intracranial hypertension (IIH) is a condition of unclear etiology that typically occurs in young, obese women in the reproductive years, which causes headaches, papilledema, and possible vision loss. 1–5 Some prior studies, largely consisting of case reports, 6–10 suggest a link between oral contraceptive pills (OCPs) and an increased risk of intracranial hypertension, 7, 8, 11–15 while other studies have not shown this association. 2, 16–19 There are also a few studies suggesting a possible association between IIH and non-OCP hormonal contraceptives, such as the levonorgestrel intrauterine device (IUD), contraceptive implants, and medroxyprogesterone.…”

Section: Introductionmentioning

confidence: 99%

“…2, 16–19 There are also a few studies suggesting a possible association between IIH and non-OCP hormonal contraceptives, such as the levonorgestrel intrauterine device (IUD), contraceptive implants, and medroxyprogesterone. 6, 9–11, 15, 20, 21 The connection between hormonal contraceptives and IIH, therefore, remains controversial among clinicians and the general public. Any study evaluating the connection between hormonal contraceptives and IIH must take into account possible bias from the demographics of the disease, since women of childbearing age are the most likely population to use contraceptives.…”

Section: Introductionmentioning

confidence: 99%

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A Population-Based, Case-Control Evaluation of the Association Between Hormonal Contraceptives and Idiopathic Intracranial Hypertension

Kilgore

Lee

Leavitt

et al. 2019

American Journal of Ophthalmology

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Purpose To determine if the use of oral contraceptive pills (OCP) and other hormonal contraceptives are associated with a higher incidence of idiopathic intracranial hypertension (IIH). Design Retrospective, population-based, case-control study Methods Setting Female IIH patients evaluated between January 1, 1990 and December 31, 2016 were identified using the Rochester Epidemiology Project (REP), a record-linkage system of medical records for all patient-physician encounters among Olmsted County, Minnesota, residents. Study Population Fifty-three female residents of Olmsted County diagnosed with IIH between 15 and 45 years of age. The use of OCPs and other hormonal contraceptives was compared to controls matched for age, sex and body-mass index. Interventions/Exposures Hormonal contraceptives Main Outcome Measure Odds of developing IIH Results Of the 53 women diagnosed with IIH between 15 and 45 years of age, 11 (20.8%) had used hormonal contraceptives within ≤30 days of the date of IIH diagnosis, in contrast to 30 (31.3%) among the control patients. The odds ratio of hormonal contraceptive use and IIH was 0.55 (95% CI: 0.24–1.23, p=0.146). The odds ratio of OCP use was 0.52 (95% CI: 0.20–1.34, p=0.174). Conclusions OCP and other hormonal contraceptives were not significantly associated with a higher incidence of IIH, arguing against the need for women with IIH to discontinue their use.

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