Risk of infections in patients with myeloproliferative neoplasms—a population-based cohort study of 8363 patients

Abstract

Infections are a common complication in patients with many hematologic malignancies, however whether patients with myeloproliferative neoplasms (MPN) also are at an increased risk of infections is largely unknown. To assess the risk of serious infections, we performed a large population-based matched cohort study in Sweden including 8 363 MPN patients and 32 405 controls using high-quality registers between the years 1992-2013 with follow-up until 2015. The hazard ratio (HR) of any infection was 2.0 (95% confidence interval 1.9-2.0), of bacterial infections 1.9 (1.8-2.0), and of viral infections 2.1 (1.9-2.3). One of the largest risk increases was that of sepsis, HR 2.6 (2.4-2.9). The HR of any infection was highest in primary myelofibrosis 3.7 (3.2-4.1), and significantly elevated in all MPN subtypes; 1.7 (1.6-1.8) in polycythemia vera and 1.7 (1.5-1.8) in essential thrombocythemia. There was no significant difference in risk of infections between untreated patients and patients treated with hydroxyurea or interferon-α during the years 2006-2013. These novel findings of an overall increased risk of infections in MPN

Risk of infection in MPN patients in the era of Covid‐19: A prospective multicenter study of 257 patients from the CML‐MPN Quebec Research Group

“…1,3 Though limited by factors including potential recall and regional biases, as well as logistics beyond the scope of this report, such as disease and therapy duration, co-morbidities, complete drug history, or infection grade, the current study critically represents a large dataset derived from an "all-comers" highly inclusive MPN registry, circumventing the bias towards reporting solely severe infections/hospitalizations, and addresses fundamental questions about the prevalent phenomenon of infections in MPN from a practical, real-world standpoint. Interestingly, our data did not disclose a significant association between infection risk and advanced age, a finding which concurs with some, 1 though not other reports, 2 suggesting an uncertain role for age as a substantive, isolated risk factor for infections in MPN.…”

“…1 Other less-common cytogenetic aberrations have also been noted, including deletion of 6q in 3-7% of CLL cases. 1,2 The prognostic significance of del6q23 remains controver-…”

Frequency of infections in 948 MPN patients: a prospective multicenter patient-reported pilot study

“…However, it is not known to which extent the underlying malignancy (MPN) contributes to immunosuppression and susceptibility to infection. Studies from a registry provided early evidence that the risk of MPN patients to die from infections may be increased when compared with normal population controls [2] and this finding was most recently underpinned by a large dataset of 8363 MPN patients [3]. MPN patients were at higher risk for severe bacterial and viral infections judged by hospital admissions and deaths from infection.…”

The Binary Classification of Protein Kinases

“…Pneumocystis jirovecii, Hepatitis B, Staphylococci, Streptococci, Haemophilus influenzae, Varicella zoster virus, Influenza, Escherichia coli, Mycobacterium tuberculosis (Mbt). 94 …”