Risk of hypoglycemia in youth with type 2 diabetes on insulin

Shahid, Madhia; Shaibi, Gabriel Q.; Baines, Hayley; Garcia-Filion, Pamela; Gonzalez-Garcia, Zoe; Olson, Micah L.

doi:10.1515/jpem-2018-0014

Cited by 4 publications

(2 citation statements)

References 39 publications

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“…The frequency of SH necessitating treatment in ED was low in adults with young-onset T2D. This concurs with reports that hypoglycaemia is infrequent in youth-onset populations, 19,20 but studies have seldom examined SH in this group. It is possible that the few severe events recorded in the present young-onset population may simply reflect the small number attending the ED and does not reflect the frequency of SH treated outside hospital.…”

Section: Discussionsupporting

confidence: 88%

Severe hypoglycaemia in adults presenting to a hospital emergency department: Clinical characteristics, comorbidities, and mortality outcomes

Song

Frier

2023

Diabetes Obesity Metabolism

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AimsTo determine the clinical characteristics, risk factors and mortality outcomes associated with severe hypoglycaemia (SH) treated at a hospital emergency department.Materials and MethodsAdult patients presenting with SH to the Northern General Hospital, Sheffield, UK over a 44‐month period were assessed for clinical characteristics, coexisting comorbidities and mortality outcomes, including cause of death, and analysed by age of diabetes onset, below and above age 40 years. Factors that predicted mortality were determined.ResultsA total of 619 episodes of SH occurred in 506 individuals. Most had type 1 (T1D; n = 172 [34.0%]) or type 2 diabetes (T2D; n = 216 [42.7%]), but several attendees did not have diabetes (non‐DM; n = 110 [21.7%]). Irrespective of age of diabetes onset, patients with T2D had more socioeconomic deprivation and comorbidities (P < 0.005). SH was uncommon in those with young‐onset T2D, who constituted 7.2% of all episodes in diabetes. Hospital admission was high (60%‐75%). The T2D cohort had the longest inpatient stay (median 5 days, vs. 2 and 3 days for the T1D and non‐DM cohorts, respectively). Survival after the index SH episode was lower and mortality was higher in the non‐DM (39.1%) and T2D (38.0%) cohorts than the T1D cohort (13.3%; all P < 0.05), with a median time to death of 13, 113 and 465 days, respectively. Most deaths (78%‐86%) were from non‐cardiovascular causes. Charlson index predicted mortality and poor survival in T1D and T2D (both P < 0.05).ConclusionsSevere hypoglycaemia requiring emergency hospital treatment is associated with non‐cardiovascular deaths and exerts a disproportionately greater impact on mortality in people with T2D and those without diabetes. Multimorbidity is an important risk factor for SH and increases mortality risk.

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Section: Discussionsupporting

confidence: 88%

Severe hypoglycaemia in adults presenting to a hospital emergency department: Clinical characteristics, comorbidities, and mortality outcomes

Song

Frier

2023

Diabetes Obesity Metabolism

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“…11 Symptomatic hypoglycemia: Fingerstick glucose of ≤70 mg/Dl. 12 Soft drink consumption: depend on validity and reproducibility of a 145-item self-administered food frequency questionnaire (FFQ), and according to it all patients sample were asked about consumption of soft drink then divided to no consumption when using less than 1 can/ week (375mL), moderate when using 1-4 cans/week, severe when using more than 5 cans/week. 13,14…”

Section: Methodsmentioning

confidence: 99%

Diet Sugar-Free Carbonated Soda Beverage, Non-Caloric Flavors Consumption, and Diabetic Retinopathy: Any Linkage

Mirghani

Alali

ALBalawi

et al. 2021

DMSO

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Purpose: Assessing diabetic retinopathy (DR) risk factors and daily nutrition habits are vital for prevention. This study aims to evaluate the relationship between diet soda cans, nonnutritive sweetener consumption, and diabetic retinopathy. Patients and Methods: A cross-sectional study was conducted among 200 patients attending a diabetes center in Tabuk City, Saudi Arabia, from September 2019 to July 2020. A structured questionnaire was used to collect patients' demographic factors, and DR risk factors including the use of diet soda, non-nutritive sweeteners, and exercise habits. Dilated fundus eye examination was done to detect any diabetic retinopathy. A blood sample was taken for measuring glycated hemoglobin to assess the degree of glycemic control. Results: The participant's age was 50.74 ±13.51 years, and the duration since the diagnosis of diabetes was 9.99 ±6.97 years, body mass index was 27.28 ±4.68, and HbA1c %, 8.50 ±1.61), the patients used to consume 1.31 ±1.57 diet soda cans/week, and 1.06±1.39 artificial sweeteners/sachet/day. DR was found in 33%. Diet sugar-free carbonated soda beverage was associated with poor glycemic control and retinopathy, while non-caloric flavor consumption was associated with obesity (P-value<0.05). No association was evident regarding other factors (P-value>0.05). Conclusion: Diet sugar-free carbonated soda beverage was associated with higher HbA1c and retinopathy, while non-caloric flavor consumption was associated with obesity. No association was evident regarding other factors. Further larger multicenter studies are needed.

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Type 2 Diabetes and Pre-Diabetes in Pediatric Obesity

Bensignor

2023

Managing Pediatric Obesity Using Advanced Therapies

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Risk of hypoglycemia in youth with type 2 diabetes on insulin

Abstract: The results of this study suggest that the risk of hypoglycemia in youth with T2D on insulin therapy is low.

Cited by 4 publications

References 39 publications

Severe hypoglycaemia in adults presenting to a hospital emergency department: Clinical characteristics, comorbidities, and mortality outcomes

Severe hypoglycaemia in adults presenting to a hospital emergency department: Clinical characteristics, comorbidities, and mortality outcomes

Diet Sugar-Free Carbonated Soda Beverage, Non-Caloric Flavors Consumption, and Diabetic Retinopathy: Any Linkage

Type 2 Diabetes and Pre-Diabetes in Pediatric Obesity

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