Risk of Heart Failure in Patients With Recent-Onset Type 2 Diabetes: Population-Based Cohort Study

Leung, Alexander A. C.; Eurich, Dean T.; Lamb, Darcy A.; Majumdar, Sumit R.; Johnson, Jeffrey; Blackburn, David; McAlister, Finlay A.

doi:10.1016/j.cardfail.2008.10.004

Cited by 33 publications

(28 citation statements)

References 28 publications

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“…1- 6 It has long been recognized that patients with diabetes have a higher incidence of cardiovascular disease, including a two-to four-fold higher risk of heart failure, than people without diabetes. [7][8][9][10][11] However, we do not fully understand the link between diabetes and development of heart failure. For example, we still do not know whether diabetes causes heart failure directly or whether the higher risk of heart failure simply reflects the greater frequency of hypertension and myocardial infarction in patients with diabetes.…”

Section: Introductionmentioning

confidence: 99%

Risk of Incident Heart Failure in Patients With Diabetes and Asymptomatic Left Ventricular Systolic Dysfunction

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Risk of Incident Heart Failure in Patients With Diabetes and Asymptomatic Left Ventricular Systolic Dysfunction

et al. 2018

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“…Heart failure incidence in patients with diabetes mellitus is much higher than in the general population [2] and is related to lower survival and lower responsiveness to treatments [3]. …”

Section: Introductionmentioning

confidence: 99%

Vitamin D Insufficiency Is Associated with Lower Physical Function in Patients with Heart Failure and Diabetes

Lopes

Ribeiro

Ledur

et al. 2014

Journal of Diabetes Research

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Vitamin D deficiency is frequent among patients with heart failure (HF) and diabetes, disorders associated with exercise intolerance and muscle weakness. This study aims to search for associations between vitamin D sufficiency and physical function indexes in patients with HF and diabetes. A cross-sectional study of 146 HF patients, 39.7% with diabetes, at a Brazilian tertiary outpatient clinic was performed. Patients underwent clinical evaluation, 6-minute walk test (6 MWT), handgrip strength, physical activity level (IPAQ), and biochemical evaluations including serum 25-hydroxyvitamin D. Classification was done according to vitamin D status (≥30 ng/dL, sufficient) and presence/absence of diabetes in vitamin sufficient, no diabetes (DS-C, n = 25), vitamin sufficient, diabetes (DS-DM, n = 18), vitamin deficient, no diabetes (DD-C, n = 63), and vitamin deficient, diabetes (DD-DM, n = 40). Patients age was 55.4 ± 8 yrs; 70.5% had vitamin D deficiency. Clinical characteristics were similar among groups. Total time expended in physical activity was similar among groups (P = 0.26). DS-C covered higher distances in the 6 MWT (392 ± 60 m) versus DD-DM (309 ± 116 m); P = 0.024. Handgrip strength was similar among groups but tended to lower levels in DD-DM (P = 0.074) even after being adjusted to physical activity (P = 0.069). Vitamin D deficiency can influence physical function in HF diabetic patients.

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“…Giles et al [21] further compared pioglitazone and glyburide given for 6 months and found a higher incidence of heart failure hospitalizations witTab. 3 Multivariable predictors a of antidiabetic drug prescription after adjustment at baseline expressed as odds ratios (95% CI) hout an increase in cardiovascular mortality or worsening cardiac function for pioglitazone.…”

Section: Antidiabetic Pharmacotherapymentioning

confidence: 99%

“…The risk increases with age and is also frequently associated with coronary heart disease [3,4]. Affected patients have a poor prognosis with a median survival of 3.6 in diabetic patients with heart failure vs. 5.4 years in patients with heart failure but without diabetes, even after adjusting for conventional risk factors [5,6].…”

Section: Introductionmentioning

confidence: 99%

Comorbidity, hypoglycaemia and appropriate selection of antidiabetic pharmacotherapy in diabetic patients with heart failure in clinical practice in Germany

Gitt

Bramlage

Binz

et al. 2012

Herz

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Patients with type 2 diabetes and heart failure had a substantially increased comorbidity burden compared to patients without heart failure. They more often suffered from episodes of hypoglycaemia, especially those requiring medical assistance. The diagnosis of heart failure did not impact the choice of antidiabetic pharmacotherapy in patients with type 2 diabetes. There was no differential use of thiazolidinediones despite evidence discouraging their use in patients with heart failure.

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Risk of Heart Failure in Patients With Recent-Onset Type 2 Diabetes: Population-Based Cohort Study

Cited by 33 publications

References 28 publications

Risk of Incident Heart Failure in Patients With Diabetes and Asymptomatic Left Ventricular Systolic Dysfunction

Risk of Incident Heart Failure in Patients With Diabetes and Asymptomatic Left Ventricular Systolic Dysfunction

Vitamin D Insufficiency Is Associated with Lower Physical Function in Patients with Heart Failure and Diabetes

Comorbidity, hypoglycaemia and appropriate selection of antidiabetic pharmacotherapy in diabetic patients with heart failure in clinical practice in Germany

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