Risk of gastric cancer is associated with<i>PRKAA1</i>gene polymorphisms in Koreans

Kim, Yong‐Dae; Yim, Dong‐Hyuk; Eom, Sang‐Yong; Moon, Sun In; Yun, Hyo-Yung; Song, Young‐Jin; Youn, Sei-jin; Hyun, Taisun; Park, Joo-Seung; Kim, Byung Sik; Lee, Jong‐Young; Won, Hee Kwan; Kim, Heon

doi:10.3748/wjg.v20.i26.8592

Cited by 18 publications

(26 citation statements)

References 23 publications

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“…Genetic‐ and gene‐environmental effects of PRKAA1 rs10074997 and rs13361707 on the risk of gastric cancer were almost identical. This identical pattern can be explained by the strong linkage disequilibrium between the two SNPs . In the evaluation of gene‐environment interactions between the PRKAA1 rs13361707 genotype and CagA status of HP infection as related to gastric cancer incidence, the RERI was 0.50 (95% CI: 0.30–0.70; P < 0.001), indicating a significant interaction (Table ).…”

Section: Resultsmentioning

confidence: 90%

“…Genetic polymorphisms in protein kinase AMP-activated alpha 1 catalytic subunit (PRKAA1) are significantly associated with gastric cancer, according to genome-wide association study (GWAS) performed in Asians [14]. Identical associations were indicated in our previous study [15] and in several other studies performed in Korean and Chinese populations [16][17][18][19], and were reconfirmed in a recent GWAS performed with a European populations [20]. Although the definitive role of PRKAA1 has not yet been identified, 5′-AMP-activated protein kinase (AMPK) encoded by PRKAA1 can play a significant role in carcinogenesis, as it is involved in energy metabolism, cell cycle regulation, cell proliferation, and rapamycinpathway inhibition [21][22][23].…”

Section: Introductionmentioning

confidence: 87%

“…Quality and quantity requirements for genotyping DNA samples were determined by identifying intact DNA bands after 2% agarose gel electrophoresis, and their concentrations were measured at >20 ng/ μ L with a degree of purity >1.7. Genotype analysis was performed for the five single‐nucleotide polymorphisms (SNPs; rs10074991, rs13361707, rs154268, rs3805486, and rs6882903) associated with PRKAA1 using a GoldenGate assay (Illumina, San Diego, CA, USA). The call rates for the examined samples and SNPs were 100%, with all five SNPs meeting the Hardy–Weinberg equilibrium in the control group.…”

Section: Methodsmentioning

confidence: 99%

“…PRKAA1-related mechanisms associated with gastric carcinogenesis remain unknown. However, several studies consistently reported associations between PRKAA1 rs13361707 and gastric cancer [14,15,[17][18][19][20]. Additionally, a recent meta-analysis concerning PRKAA1 polymorphisms found that the PRKAA1 rs13361707 C allele was strongly associated with risk of noncardia gastric cancer [28].…”

Section: Nod2)mentioning

confidence: 99%

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Additive interactions between PRKAA1 polymorphisms and Helicobacter pylori CagA infection associated with gastric cancer risk in Koreans

et al. 2016

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Although several studies reported genetic polymorphisms in protein kinase AMP‐activated alpha 1 catalytic subunit (PRKAA1) and their associations with gastric cancer risk, few have evaluated associations between Helicobacter pylori infection and PRKAA1 gene‐environment interactions. Here, we evaluated the effects of interactions between H. pylori infection and PRKAA1 polymorphisms on gastric cancer risk in Koreans. In this hospital‐based case–control study, PRKAA1 genotypes were analyzed and H. pylori infection and CagA status were examined using a serologic method in 846 pairs of gastric cancer patients and controls matched for age and sex. H. pylori seropositivity was associated with a 1.43‐fold [95% confidence interval: 1.12–1.81] increase in the risk of gastric cancer, and CagA low‐positive titers during H. pylori infection increased the risk by 1.85‐fold (95% confidence interval, 1.38–2.48). Significant positive interaction between the PRKAA1 rs13361707 genotype and H. pylori infection was verified on an additive scale [relative excess risk due to interaction, 0.55; 95% confidence interval, 0.05–1.04; P = 0.030], and the gene‐environment interaction between PRKAA1 rs13361707 and CagA status was also statistically significant (relative excess risk due to interaction, 0.50; 95% confidence interval, 0.30–0.70; P < 0.001). Our results indicated that H. pylori infection, CagA status, and PRKAA1 polymorphisms were risk factors for gastric cancer in Koreans, and that the combination of two of these factors rather than their independent effects synergistically increased the risk.

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Section: Resultsmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 87%

Section: Methodsmentioning

confidence: 99%

Section: Nod2)mentioning

confidence: 99%

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Additive interactions between PRKAA1 polymorphisms and Helicobacter pylori CagA infection associated with gastric cancer risk in Koreans

et al. 2016

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“…For the subsequent meta-analysis, we found four primary studies [ 16 , 24 – 26 ]. By including the present study, a total of five studies with 9,590 cases and 9,724 controls were included in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population

Qiu

Cheng

et al. 2015

Oncotarget

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Published data on the association between PRKAA1 rs13361707 T > C polymorphism and gastric cancer (GCa) susceptibility were inconclusive. To derive a more precise estimation of the association, we conducted a large-scale GCa study of 1,124 cases and 1,194 controls to confirm this association in an Eastern Chinese population. Our results showed that the C allele of PRKAA1 rs13361707 increased the GC risk in the study population [CT vs. TT, odds ratio (OR) = 1.72, 95% confidence interval (CI) = 1.40–2.12; CC vs. TT, OR = 2.15, 95%CI = 1.70–2.71; CT/CC vs. TT, OR = 1.86, 95%CI = 1.53–2.26; CC vs.TT/CT, OR = 1.49, 95%CI = 1.24–1.79]. In addition, the association of C allele with an increased GCa risk was still significant in subgroups, when stratified by age, sex, tumor site, drinking and smoking status. Moreover, the findings in the present study were validated by our further meta-analysis. In summary, these results indicated that the C allele of PRKAA1 rs13361707 was a low-penetrate risk factor for GCa.

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PRKAA1 rs13361707 C/T polymorphism confers decreased susceptibility to esophageal cancer: A case‐control study

Zhao

Zang

2020

Clinical Laboratory Analysis

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Background Several studies probed into the connection between esophageal cancer (EC) risk and PRKAA1 rs13361707 C/T polymorphism, but obtained insignificant findings. Methods In this study, 814 EC cases and 961 controls from Eastern China were recruited to validate the relationship between this polymorphism and EC susceptibility. Results Data suggested rs13361707 C/T polymorphism in PRKAA1 gene was significantly related with a lower risk for EC. Such significant connection was also uncovered in subgroups of males, smokers, drinkers and individuals with age ≥ 60 years. In addition, this polymorphism was linked with the pathological grading, distant metastasis, and histology of EC. Conclusion In summary, PRKAA1 rs13361707 C/T polymorphism is related to the risk and clinical properties of EC patients in East China.

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Risk of gastric cancer is associated withPRKAA1gene polymorphisms in Koreans

Abstract: All 5 tested tag SNPs of the PRKAA1 gene (rs13361707, rs154268, rs3805486, rs6882903, and rs10074991) were significantly associated with gastric cancer.

Cited by 18 publications

References 23 publications

Additive interactions between PRKAA1 polymorphisms and Helicobacter pylori CagA infection associated with gastric cancer risk in Koreans

Additive interactions between PRKAA1 polymorphisms and Helicobacter pylori CagA infection associated with gastric cancer risk in Koreans

Genetic variant of PRKAA1 and gastric cancer risk in an eastern Chinese population

PRKAA1 rs13361707 C/T polymorphism confers decreased susceptibility to esophageal cancer: A case‐control study

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