Risk of first onset of colorectal cancer associated with alcohol consumption in Lynch syndrome: a multicenter cohort study

Fujiyoshi, Kenji; Sudo, Tomoya; Fujita, Fumihiko; Chino, Akiko; Akagi, Kiwamu; Takao, Akinari; Yamada, Masayoshi; Tanakaya, Kohji; Ishida, Hideyuki; Kono, Koji; Ishihara, Soichiro; Miguchi, Masashi; Hirata, Keiji; Miyakura, Yasuyuki; Ishikawa, Toshiaki; Yamaguchi, Tatsuro; Tomita, Naohiro; Ajioka, Yoichi; Sugihara, Kenichi

doi:10.1007/s10147-022-02148-2

Cited by 4 publications

(7 citation statements)

References 35 publications

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“…Four studies including 2,900 people with Lynch syndrome assessed the relationship between alcohol consumption and CRC risk. 28,29,37,38 Overall, individuals with Lynch syndrome who reported current or past alcohol consumption had no significantly different risk of developing CRC (pooled HR, 1.32 [95% CI, 0.97 to 1.81]; Fig 4). There was moderate heterogeneity ( I 2 = 60%; P = .08).…”

Section: Resultsmentioning

confidence: 99%

“…33 One Japanese study found no difference (HR, 0.86 [95% CI, 0.61 to 1.20]) between ever-smokers and never-smokers in terms of CRC risk. 28 In a retrospective cohort study at a high risk of bias from Taiwan, there was no association between CRC risk among ever-smokers, compared with never-smokers (HR, 1.06 [95% CI, 0.73 to 1.52]). 29 A prospective study from the GEOLynch cohort investigated the association between smoking and colorectal adenomas among those with Lynch syndrome.…”

Section: Smokingmentioning

confidence: 95%

“…A total of five studies involving 2,323 individuals with Lynch syndrome assessed the relationship between tobacco consumption and the risk of CRC. [28][29][30]33,38 Among four studies with comparable end points, the pooled HR for the development of CRC in ever-smokers compared with never-smokers was 1.04 (95% CI, 0.82 to 1.32; Fig 3), suggesting no association. There was no significant heterogeneity (I 2 5 44.3%; P 5 .15).…”

Section: Smokingmentioning

confidence: 98%

“…A total of 18 studies met all the inclusion criteria, involving 16,312 patients with Lynch syndrome. [24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] Eleven studies were retrospective cohort studies, whereas seven were prospective cohort studies, of which one was performed as part of a randomized trial (Table 1). All studies included patients diagnosed with Lynch syndrome by a germline pathogenic variant in a mismatch repair gene, but two studies just included those with MLH1 and MSH2 pathogenic variants.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Modifiable Risk Factors and Risk of Colorectal and Endometrial Cancers in Lynch Syndrome: A Systematic Review and Meta-Analysis

Power,

Doherty,

Parker

et al. 2024

JCO Precis Oncol

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PURPOSE Lynch syndrome is the most common hereditary cause of colorectal and endometrial cancers. Modifiable risk factors, including obesity, physical activity, alcohol intake, and smoking, are well-established in sporadic cancers but are less studied in Lynch syndrome. METHODS Searches were conducted on MEDLINE, Embase, and Web of Science for cohort studies that investigated the association between modifiable risk factors and the risk of colorectal or endometrial cancer in people with Lynch syndrome. Adjusted hazard ratios (HRs) and 95% CIs for colorectal and endometrial cancers were pooled using a random effects model. The protocol was prospectively registered on PROSPERO (CRD 42022378462), and the meta-analysis was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses and Meta-Analysis of Observational Studies in Epidemiology reporting guidelines. RESULTS A total of 770 citations were reviewed. Eighteen studies were identified for qualitative synthesis, with seven colorectal cancer (CRC) studies eligible for meta-analysis. Obesity (HR, 2.38 [95% CI, 1.52 to 3.73]) was associated with increased CRC risk. There was no increased CRC risk associated with smoking (HR, 1.04 [95% CI, 0.82 to 1.32]) or alcohol intake (HR, 1.32 [95% CI, 0.97 to 1.81]). Type 2 diabetes mellitus (T2DM) and some dietary factors might increase risk of CRC although more studies are needed. In a qualitative synthesis of three endometrial cancer cohort studies, female hormonal risk factors and T2DM may affect the risk of endometrial cancer, but obesity was not associated with an increased risk. CONCLUSION Lifestyle recommendations related to weight and physical activity may also be relevant to cancer prevention for individuals with Lynch syndrome. Further high-quality prospective cohort studies, in particular, including endometrial cancer as an end point, are needed to inform evidence-based cancer prevention strategies in this high-risk population.

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Section: Resultsmentioning

confidence: 99%

Section: Smokingmentioning

confidence: 95%

Section: Smokingmentioning

confidence: 98%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Modifiable Risk Factors and Risk of Colorectal and Endometrial Cancers in Lynch Syndrome: A Systematic Review and Meta-Analysis

Power,

Doherty,

Parker

et al. 2024

JCO Precis Oncol

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“…While there is extensive evidence supporting the relationship between modifiable lifestyle behaviors and cancer [ 3 , 42 ], included studies assessed only a few behavioral factors, mainly diet and physical activity. Alcohol intake is associated with the risk of breast, colorectal, liver, and other cancer [ 43 ], but it was not addressed in the included articles.…”

Section: Discussionmentioning

confidence: 99%

Lifestyle Behavior Interventions for Preventing Cancer in Adults with Inherited Cancer Syndromes: Systematic Review

Serna

Fernández

Lluch‐Canut

2022

IJERPH

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(1) Background: The link between lifestyle behaviors and cancer risk is well established, which is important for people with personal/family history or genetic susceptibility. Genetic testing is not sufficient motivation to prompt healthier lifestyle behaviors. This systematic review aims to describe and assess interventions for promoting healthy behaviors in people at high risk of cancer. (2) Methods: The review was performed according to PRISMA guidelines using search terms related to hereditary cancer and health education to identify studies indexed in: CINAHL, MEDLINE, PubMed, Cochrane Library, Scopus, and Joanna Briggs, and published from January 2010 to July 2022. (3) Results: The search yielded 1558 initial records; four randomized controlled trials were eligible. Three included patients with and without a personal history of cancer who were at increased risk of cancer due to inherited cancer syndromes, and one included people undergoing genetic testing due to family history. Interventions targeted diet, physical activity, and alcohol. (4) Conclusions: There is a paucity of research on interventions for promoting healthy lifestyle behaviors in people with a high risk of cancer. Interventions produced positive short-term results, but there was no evidence that behavioral modifications were sustained over time. All healthcare professionals can actively promote healthy behaviors that may prevent cancer.

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A Japanese case of ovarian mucinous adenocarcinoma with germline double variants of MSH2 and BRCA2

et al. 2023

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Risk of first onset of colorectal cancer associated with alcohol consumption in Lynch syndrome: a multicenter cohort study

Cited by 4 publications

References 35 publications

Modifiable Risk Factors and Risk of Colorectal and Endometrial Cancers in Lynch Syndrome: A Systematic Review and Meta-Analysis

Modifiable Risk Factors and Risk of Colorectal and Endometrial Cancers in Lynch Syndrome: A Systematic Review and Meta-Analysis

Lifestyle Behavior Interventions for Preventing Cancer in Adults with Inherited Cancer Syndromes: Systematic Review

A Japanese case of ovarian mucinous adenocarcinoma with germline double variants of MSH2 and BRCA2

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