Risk of Exposure to Marketed Milk with Antimicrobial Drug Residues in Ghana

Aning, K.G.; Donkor, E. S.; Omore, A.; Nurah, G. K.; Osafo, E.L.K.; Staal, S.

doi:10.2174/187425640701011046

Cited by 6 publications

(7 citation statements)

References 1 publication

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“…Also, the results of the evaluation of tetracycline and oxytetracycline residues in milk samples in Tehran province indicated that above 8.7% of milk samples were positive for antibiotic residues (Rassouli et al, 2010). In Ghana, Aning et al (2007) reported on the analysis of raw milk samples (394 samples) marketed in two major cities, Accra and Kumasi. Thirty-five percent of the samples were contaminated with one or more of the five families of antibiotics (βetalactams, tetracycline, aminoglycosides, macrolides and sulphonamides) screened.…”

Section: Discussionmentioning

confidence: 99%

Assessment of microbiological and residual antibiotics status in milk sold in Abeokuta, Ogun State. Nigeria

Oluwafemi

Oluwabamiwo

Oluwatosin

et al. 2018

Turkish JAF Sci.Tech.

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This study investigated the prevalence and concentration of antibiotic residues in twenty brands of milk. Determination and quantification of antibiotic residues was done using High Performance Liquid Chromatography. Aerobic plate count was carried out and the associated bacteria isolated. Identification of bacteria was done using standard microbiological methods. Molecular characterization and identification of bacterial isolates was done using 16S rRNA gene sequencing method. Antibiotic sensitivity was carried out on bacterial isolates using disc diffusion method. Plasmid profile of drug resistant isolates was done using alkaline analysis method. Comparison of means was done using Analysis of Variance. Antibiotic residues were detected in 10 (50%) of the 20 milk brands analyzed. The residual levels of tetracycline, oxytetracycline and chlortetracycline ranged between 5ng/kg and 1569ng/kg while none of the samples had doxycycline residues. The prevalence of tetracycline residues in evaporated milk brands and powdered milk samples were 100 and 23 % respectively. The aerobic plate counts ranged from 2.5 × 10 2 to 6.5 × 10 2 CFU∕mL for evaporated milk and 2.5 × 10 1 to 6.0 × 10 1 CFU∕mL for powdered milk. A total of ten bacterial species were isolated and identified. Susceptibility result showed that 95% of the isolates were sensitive to erythromycin, cefuroxime and gentamycin; 12.5% were resistant to tetracycline and ampicillin, 10% were resistant to ofloxacin and 7.5% to doxycycline and penicillin. Five of the bacterial isolates were resistant to more than one class of antibiotics. Resistant isolates subjected to plasmid profiling had detectable plasmids with estimated sizes between 120bp and 1000bp. The obtained results provide evidence that the presence of antibiotic residues in evaporated and powdered milk is an indication that the public is exposed to the harmful effects of the residues.

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Section: Discussionmentioning

confidence: 99%

Assessment of microbiological and residual antibiotics status in milk sold in Abeokuta, Ogun State. Nigeria

Oluwafemi

Oluwabamiwo

Oluwatosin

et al. 2018

Turkish JAF Sci.Tech.

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“…For example, in Brazil, a study to assess hazards in unpasteurized marketed milk at farm level found a prevalence of antimicrobial residues of 11.5% [ 29 ]. A study in the peri-urban areas of Accra and Kumasi cities in Ghana [ 14 ] found that 35.5% of samples of raw marketed milk, collected from different marketing agents including farmers, processors, wholesalers and retailers, were contaminated with antimicrobial residues. In Tanzania, a prevalence of 36% was observed in a study to investigate the risk of exposure to antimicrobial residues present in marketed raw milk in Mwanza and Dar es Salaam [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

“…In Kenya, quality and safety of milk is regulated by the Dairy Industry Act [ 11 ], Public Health Act [ 12 ] and the Standards Act [ 13 ]. However, such regulations might not be adhered to or enforced, as is the case in many developing countries [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial residues and compositional quality of informally marketed raw cow milk, Lamu West Sub-County, Kenya, 2015

et al. 2017

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Introductionunadulterated milk, free of antimicrobial residues is important for industrial processing and consumers’ health. Antimicrobial residues in foods of animal origin can cause adverse public health effects like drug resistance and hypersensitivity. Milk produced in Lamu West sub-county is sold raw directly to consumers. We estimated the compositional quality and prevalence of antimicrobial residues in informally marketed raw cow milk in Lamu West Sub-County, Kenya.Methodswe randomly recruited 152 vendors and 207 farmers from four randomly selected urban centers in a cross-sectional study and interviewed them using a pretested standardized questionnaire. A100-ml raw milk sample was aseptically collected from each vendor and farm and tested for antimicrobial residues using Charm Blue Yellow II kit following the European Union Maximum Residue Limits (EU-MRLs) while an Ekomilk® Analyzer was used to measure compositional quality where samples with either solid not fat (SNF) < 8.5 or added water ≥ 0.01% or both were considered adulterated. We analyzed data using univariate analysis and unconditional logistic regression to calculate odds ratios (OR) and 95% confidence intervals (CI).Resultsthirty-two of the 207 (15.5%) samples from farmers and 28 (18.4%) of the 152 samples from vendors tested positive for antimicrobial residues. Thirty-six (17.4 %) samples from farmers and 38 (25.0%) from vendors were found to be adulterated with water. Farmers’ awareness of the danger of consuming milk with antimicrobial residues and farmers having training on good milking practices were protective against selling milk with antimicrobial residues (adjusted OR and 95% CI 0.20, 0.07-0.55 and 0.33, 0.11-0.99, respectively).Conclusionthe antimicrobial residues above EU MRLs and adulteration of raw marketed cow milk observed in this study provide evidence for routine testing of marketed milk and educating farmers to observe antimicrobial withdrawal period.

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“…The presence of antibiotic residues in milk constitutes a danger for the consumer by provoking the development of resistance to antibiotics by promoting the emergence of a multiresistant microflora. It may December lencher toxic accidents or even rarely allergic disorders [2]. The problem of residues can also be the cause of the total or partial inhibition of fermentation phenomena of bacterial origin in dairy products such as yoghurts and cheeses, which represents an economic loss for the dairy industry.…”

Section: Introductionmentioning

confidence: 99%

Contribution to the Identification of Antibiotics Residues in Raw Bovine Milk in Algeria

Ouabdesselam

Benmaamar

Berbar

2020

EUR J BASIC MED SCI

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The presence of residues of veterinary drugs such as antibiotics used for the treatment of animals can be dangerous for the consumer. Indeed, residues of these drugs can end up in the form of undesirable traces in animal productions, in particular milk when there is an inappropriate use such as failure to comply with the waiting times between the administration of antibiotics to the animal and meat collection. This study is part of a global project carried out with the aim of evaluating the presence of antibiotic residues in the raw milk of cows reared in cattle farms in Blida. This study involved 200 milk samples were collected in the Wilaya of Blida. A screening of the samples was carried out by the acidification test followed by a confirmation agar diffusion test. The results showed residues in 20.51 % of the milk tested. The study revealed the presence of antibiotic residues in raw cow's milk from farms in varying proportions. Penicillin residues and / or tetracyclines were originally of the contamination of 93.62 % milk samples positive while residues macrolide and / or aminoglycoside were only detected in 6.38 % of samples tested positive. The use of antibiotics should be done by veterinarians or under their responsibility by animal health professionals.

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Risk of Exposure to Marketed Milk with Antimicrobial Drug Residues in Ghana

Cited by 6 publications

References 1 publication

Assessment of microbiological and residual antibiotics status in milk sold in Abeokuta, Ogun State. Nigeria

Assessment of microbiological and residual antibiotics status in milk sold in Abeokuta, Ogun State. Nigeria

Antimicrobial residues and compositional quality of informally marketed raw cow milk, Lamu West Sub-County, Kenya, 2015

Contribution to the Identification of Antibiotics Residues in Raw Bovine Milk in Algeria

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