Risk of epithelial ovarian cancer in asymptomatic women with ultrasound‐detected ovarian masses: a prospective cohort study within the UK collaborative trial of ovarian cancer screening (UKCTOCS)

Sharma, Aarti; Apostolidou, Sophia; Burnell, Matthew; Campbell, Stuart; Habib, Mariam; Gentry-Maharaj, A.; Amso, Nazar; Seif, Mourad W.; Fletcher, Gwendolen; Singh, Naveena; Benjamin, E.; Brunell, Carol; Turner, George F.; Rangar, Rani; Godfrey, Keith; Oram, David; Herod, Jonathan; Williamson, Karin; Jenkins, Howard J.; Mould, Tim; Woolas, Robert; Murdoch, J.; Dobbs, Stephen; Leeson, Simon; Cruickshank, D.J.; Fourkala, Evangelia-O; Ryan, Andy; Parmar, Mahesh; Jacobs, Ian; Menon, Usha

doi:10.1002/uog.12270

Cited by 69 publications

(71 citation statements)

References 22 publications

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“…Due to the potential morbidity of surgical treatments, clinical monitoring may be recommended since a large proportion of these cysts are associated with low risk for developing ovarian cancer 1,24 (B).…”

Section: Good Practices In Treatmentmentioning

confidence: 99%

“…Due to the wide use of pelvic and transvaginal ultrasound for routine gynecological evaluation, during the reproductive years and after menopause, the incidental finding of adnexal masses has been observed in a growing proportion of women, leading to discussions on the approach to be used in asymptomatic patients 1 (B). One of the main concerns of the gynecologist is the identification of risk markers for the development of ovarian cancer, which may lead to early surgical treatment and prevent progression of the disease during the expectant conservative treatment.…”

Section: Introductionmentioning

confidence: 99%

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Clinical management of incidental findings on pelvic adnexal masses

Dias

Bueloni-Dias

Delmanto

et al. 2015

Rev. Assoc. Med. Bras.

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Summary Due to widespread use of pelvic and transvaginal ultrasound in routine gynecological evaluation, the incidental finding of adnexal masses has led to discussions about management in asymptomatic patients regarding the risk of ovarian cancer. Transvaginal ultrasonography remains the modality of choice in the evaluation of suspicious characteristics. The combined analysis of ultrasound morphological parameters with Doppler study, serum carcinona antigen 125 and investigation of a symptom index may improve diagnosis. Surgical approach should be considered whenever there are suspicious images, rapid growth of cysts, changes in the appearance compared to the initial evaluation or when the patient has symptoms. Future studies on genetic and molecular mechanisms may help explain the pathophysiology of ovarian cancer, improving early diagnosis and treatment.

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Section: Good Practices In Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical management of incidental findings on pelvic adnexal masses

Dias

Bueloni-Dias

Delmanto

et al. 2015

Rev. Assoc. Med. Bras.

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“…Despite the higher prevalence of Type II EOC, the risk of borderline or type I cancer in women with ultrasound abnormalities seems to be higher than does the risk of type II cancer. This has important immediate implications for patients with incidental adnexal findings as well as for any future ultrasound-based screening [19].…”

Section: Adenocarcinomamentioning

confidence: 99%

An Evaluation of the Applicability of the Risk of Malignancy Index for Adnexal Masses to Patients Seen at a Tertiary Hospital in Chandigarh, India

Chopra

Vaishya

Kaur

2014

J Obstet Gynecol India

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Back ground The discrimination between benign and malignant ovarian tumors is important considering to optimally plan for an appropriate surgical treatment. Aims To determine the applicability of risk of malignancy index (RMI 2) for triaging patients with adnexal masses seen at tertiary care hospital in India. Subjects and Methods A retrospective case note review of patients with adnexal masses admitted in Gynecology department was done. RMI 2 was calculated for each patient using ultrasound score, menopausal status, and CA-125 levels (U/ml), and the value of RMI was compared to the histological diagnosis. Statistical analyses were performed using SPSS version 17.0 by descriptive and inferential statistics. The p value B0.05 was considered significant. Results The Mean age and SD of hundred patients was 52.8 (10) years. Most of the patients were postmenopausal (68/100). A significant relationship of ovarian malignancy was found with increasing age, high ultrasound score, and high serum CA-125. The average value of CA-125 in benign and malignant ovarian tumor was 7.4 and 625, respectively. The RMI 2 at a cut-off value of 200 had a sensitivity of 96.7 %, specificity of 84 %, positive predictive value of 85.5 %, and negative predictive value of 67.7 %. Conclusion Our study confirms the applicability of RMI 2 [200 in diagnosing adnexal masses with high risk of malignancy. It can be easily introduced into clinical 123practice to facilitate the selection of the patients for surgery and also helpful in triaging patients to different treatment groups.

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“…[3][4][5] Malignancy has been found in apparently stable masses that eventually enlarged and increased in morphologic complexity in up to 3 years after initial detection. 6 These results gleaned from 11,982 ultrasound examinations define the risks from terminating ultrasound surveillance. 6 We have used the definition of acceptable risk level from environmental studies of no more than 1 extra death per 100,000 deaths to normalize the reported data.…”

mentioning

confidence: 98%

“…6 These results gleaned from 11,982 ultrasound examinations define the risks from terminating ultrasound surveillance. 6 We have used the definition of acceptable risk level from environmental studies of no more than 1 extra death per 100,000 deaths to normalize the reported data. 7 The absolute risks calculated from the United Kingdom Collaborative Trial of Ovarian Cancer Screening trial data for the appearance of malignancy in up to 3 years after an initial ultrasound examination are considerably elevated ( Figure 2).…”

mentioning

confidence: 98%