Risk of end-stage renal disease associated with gout: a nationwide population study

Abstract

IntroductionWe explored the risk of end-stage renal disease (ESRD) among gout patients in a representative cohort in Taiwan.MethodsThe primary database used was the Taiwan National Health Insurance Research Database. Subjects older than 20 years without ESRD, coronary heart disease, or stroke were included in the study. The case definition of gout in the present study was gout diagnosis and medical treatment for gout. An ESRD case was defined by the presence of chronic renal failure necessitating long-term renal replacement therapy. Multivariate Cox proportional hazards models were used to evaluate the risk of ESRD among gout patients.ResultsThe analysis included data of 656,108 patients who were followed up for a mean of 8.0 years. Among them, 19,963 (3.0%) patients had gout. At the end of 2008, 2,377 individuals (gout, n = 276; non-gout, n = 2,101) had ESRD, and 861 individuals (gout, n = 77, 27.9%; non-gout, n = 521, 24.8%) died due to ESRD. The rates of incidence of ESRD were 1.73 and 0.41 cases per 1,000 patient-years in the gout and non-gout groups. After adjustment for age, sex, and history of diabetes mellitus and/or hypertension, gout was associated with a hazard ratio (HR) of 1.57 for ESRD (95% confidence interval [CI], 1.38-1.79; P < 0.001). In patients with ESRD, the adjusted HR for death in patients with gout was 0.95 (0.74-1.23, P = 0.71), which was similar to the HR obtained in patients without gout.ConclusionsGout is associated with an increased hazard for development of ESRD.

Urinary Uromodulin/Creatinine Ratio as a Potential Clinical Biomarker for Chronic Kidney Disease Patients with Gout: A Pilot Study

“…Here, we expanded our previous cohort to include a non-gout population, with and without CKD, for comparison. An important assumption was that patients with an established diagnosis of gout were more likely to have chronic urate-related renal damage, as supported by recent large-scale epidemiological studies [18, 19]. Leakage of UMOD has been known to cause inflammation of renal tissue, and a previous study [7] reported that damage to the TAL of a nephron and cells distal to the TAL results in leakage of UMOD into the interstitium, and subsequent inflammation.…”

Screening the anti-gout traditional herbs from TCM using an in vitro method

“…The global epidemiology of gout data showed that the worldwide prevalence of gout ranges from 0.1% to approximately 10%, and developed countries tend to have a higher burden of gout than developing countries, while gout incidence of men is higher than women by 2-6 fold [2]. Most frequently, gout causes recurrent attacks of acute arthritis and tophi depositions, and other chronic diseases, such as common complications of renal [3], metabolic syndrome [4], hypertension and cardiovascular diseases [5,6]. Therefore, the treatment of gout has become a serious problem to solve.…”

Analysis of Oral Microbiota Revealed High Abundance of Prevotella Intermedia in Gout Patients

“…Both gout and HUA have been associated with a number of pathological conditions such as metabolic syndrome, obesity, hypertension, stroke, cardiovascular diseases, and renal diseases [3][4][5][6]. However, the effects of gout/HUA on oral health remain unknown.…”