Risk of Developmental Coordination Disorder in Italian very preterm children at school age compared to general population controls

Caravale, Barbara; Herich, Lena Carolin; Zoia, Stefania; Capone, Luca; Voller, Fabio; Carrozzi, Marco; Chiandotto, Valeria; Balottin, Umberto; Lacchei, M; Croci, Ileana; Cuttini, Marina

doi:10.1016/j.ejpn.2019.01.002

Cited by 16 publications

(15 citation statements)

References 36 publications

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“…In the mature brain, the superior parietal lobule supports not only the smooth execution of motor plans 105 but also more abstract visuospatial functions such as mental rotation. 106 The aberrant parietal connectivity we have identified at TEA could therefore be a prelude to specific difficulties occurring with high prevalence in preterm children, such as developmental coordination disorder, 107–111 inattention and intellectual impairment (reviewed in Rogers et al 112 ). Long-term follow-up of the study population at school age will be required to confirm this hypothesis.…”

Section: Discussionmentioning

confidence: 96%

The Developing Human Connectome Project: typical and disrupted perinatal functional connectivity

Eyre

Fitzgibbon

Ciarrusta

et al. 2021

Brain

116

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The Developing Human Connectome Project (dHCP) is an Open Science project which provides the first large sample of neonatal functional MRI (fMRI) data with high temporal and spatial resolution. This data enables mapping of intrinsic functional connectivity between spatially distributed brain regions under normal and adverse perinatal circumstances, offering a framework to study the ontogeny of large-scale brain organisation in humans. Here, we characterise in unprecedented detail the maturation and integrity of resting-state networks (RSNs) at term-equivalent age in 337 infants (including 65 born preterm). First, we applied group independent component analysis (ICA) to define 11 RSNs in term-born infants scanned at 43.5-44.5 weeks postmenstrual age (PMA). Adult-like topography was observed in RSNs encompassing primary sensorimotor, visual and auditory cortices. Among six higher-order, association RSNs, analogues of the adult networks for language and ocular control were identified, but a complete default mode network precursor was not. Next, we regressed the subject-level datasets from an independent cohort of infants scanned at 37-43.5 weeks PMA against the group-level RSNs to test for the effects of age, sex and preterm birth. Brain mapping in term-born infants revealed areas of positive association with age across four of six association RSNs, indicating active maturation in functional connectivity from 37 to 43.5 weeks PMA. Female infants showed increased connectivity in inferotemporal regions of the visual association network. Preterm birth was associated with striking impairments of functional connectivity across all RSNs in a dose-dependent manner; conversely, connectivity of the superior parietal lobules within the lateral motor network was abnormally increased in preterm infants, suggesting a possible mechanism for specific difficulties such as developmental coordination disorder which occur frequently in preterm children. Overall, we find a robust, modular, symmetrical functional brain organisation at normal term age. A complete set of adult-equivalent primary RSNs is already instated, alongside emerging connectivity in immature association RSNs, consistent with a primary-to-higher-order ontogenetic sequence of brain development. The early developmental disruption imposed by preterm birth is associated with extensive alterations in functional connectivity.

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Section: Discussionmentioning

confidence: 96%

The Developing Human Connectome Project: typical and disrupted perinatal functional connectivity

Eyre

Fitzgibbon

Ciarrusta

et al. 2021

Brain

116

View full text Add to dashboard Cite

show abstract

“…Although differences in probable DCD between Spanish and Dutch children were not significant, a higher prevalence of DCD in southern European children has been persistently reported [6,8,12,25,26,28,39,[43][44][45][46]. It is to be expected to find higher prevalence in regions with lower performance scores on DCD assessment measures, but a higher percentage of children with probable DCD in southern European regions is present even in those countries with population-adjusted cutoff scores, like Italy or Spain [25,26]. It should be noted that the prevalence of DCD can be influenced by the instrument used to determine the diagnosis, as objective motor coordination assessment through motor tests may differ from parent evaluation.…”

Section: Discussionmentioning

confidence: 87%

Interrelation of Individual, Country and Activity Constraints in Motor Activities of Daily Living among Typically Developing Children: A Cross-sectional Comparison of Spanish and Dutch Populations

Delgado-Lobete

Montes-Montes

Pértega-Díaz

et al. 2020

IJERPH

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Motor performance is influenced by individual, environmental, and task constraints. Children perform differently according to individual (i.e., sex), environmental (i.e., country), and task (i.e., type of activity) factors. However, little is known about the effect of the interaction between sex and country factors across different activities of daily living (ADL) learning, participation, and performance. The main aim of this study was to examine the relationship between sex, country, and type of activity in motor-based ADL learning, participation, and performance in five-to-eight-year-old, typically developing children. Additionally, we aimed to compare the prevalence of probable Developmental Coordination Disorder (DCD) across sex and country. The DCDDaily-Q was used to assess ADL learning, participation, and performance in 300 age and sex-matched children from Spain and The Netherlands. The prevalence of probable DCD was determined based on the total ADL performance score. Results showed that differences in ADL learning, participation and performance differed across sex and country (p < 0.05). Prevalence of probable DCD was statistically similar in both countries. These findings show that daily participation and performance in typically developing children may be influenced by individual, country, and task constraints, and that country and sex may have different influences on particular tasks.

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“…In the mature brain, the superior parietal lobule supports not only the smooth execution of motor plans (Simon et al, 2002) but also more abstract visuospatial functions such as mental rotation (Gogos et al, 2010). The aberrant parietal connectivity we have identified at TEA could therefore be a prelude to specific difficulties occurring with high prevalence in preterm children, such as developmental coordination disorder (Caravale et al, 2019;Davis et al, 2007;Dewey et al, 2019;Kashiwagi et al, 2009;Wilson et al, 2017), inattention and intellectual impairment (reviewed in . Long-term follow up of the study population at school age will be required to confirm this hypothesis.…”

Section: Modulation Of Parieto-motor Connectivitymentioning

confidence: 86%

The Developing Human Connectome Project: typical and disrupted perinatal functional connectivity

Eyre

Fitzgibbon

Ciarrusta

et al. 2020

Preprint

View full text Add to dashboard Cite

The Developing Human Connectome Project (dHCP) is an Open Science project which provides the first large sample of neonatal functional MRI (fMRI) data with high temporal and spatial resolution. This data enables mapping of intrinsic functional connectivity between spatially distributed brain regions under normal and adverse perinatal circumstances, offering a framework to study the ontogeny of large-scale brain organisation in humans. Here, we characterise in unprecedented detail the maturation and integrity of resting-state networks (RSNs) at normal term age in 337 infants (including 65 born preterm).First, we applied group independent component analysis (ICA) to define 11 RSNs in term-born infants scanned at 43.5-44.5 weeks postmenstrual age (PMA). Adult-like topography was observed in RSNs encompassing primary sensorimotor, visual and auditory cortices. Among six higher-order, association RSNs, analogues of the adult networks for language and ocular control were identified, but a complete default mode network precursor was not. Next, we regressed the subject-level datasets from an independent cohort of infants scanned at 37-43.5 weeks PMA against the group-level RSNs to test for the effects of age, sex and preterm birth.Brain mapping in term-born infants revealed areas of positive association with age across four of six association RSNs, indicating active maturation in functional connectivity from 37 to 43.5 weeks PMA. Female infants showed increased connectivity in inferotemporal regions of the visual association network. Preterm birth was associated with striking impairments of functional connectivity across all RSNs in a dose-dependent manner; conversely, connectivity of the superior parietal lobules within the lateral motor network was abnormally increased in preterm infants, suggesting a possible mechanism for specific difficulties such as developmental coordination disorder which occur frequently in preterm children.Overall, we find a robust, modular, symmetrical functional brain organisation at normal term age. A complete set of adult-equivalent primary RSNs is already instated, alongside emerging connectivity in immature association RSNs, consistent with a primary-to-higher-order ontogenetic sequence of brain development. The early developmental disruption imposed by preterm birth is associated with extensive alterations in functional connectivity.

show abstract

Risk of Developmental Coordination Disorder in Italian very preterm children at school age compared to general population controls

Cited by 16 publications

References 36 publications

The Developing Human Connectome Project: typical and disrupted perinatal functional connectivity

The Developing Human Connectome Project: typical and disrupted perinatal functional connectivity

Interrelation of Individual, Country and Activity Constraints in Motor Activities of Daily Living among Typically Developing Children: A Cross-sectional Comparison of Spanish and Dutch Populations

The Developing Human Connectome Project: typical and disrupted perinatal functional connectivity

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