Risk of Developing Cytomegalovirus Retinitis in Persons Infected With the Human Immunodeficiency Virus

Pertel, Peter; Hirschtick, R; Phair, John J.; Chmiel, Joan S.; Poggensee, I; Murphy, Robert L.

doi:10.1097/00006982-199313030-00016

Cited by 73 publications

(96 citation statements)

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“…In one series of 26 patients with CMV retinitis, the mean CD4 count was 15.6/mm 3 . 44 Patients present with painless visual disturbances including floaters, blurred vision, decreased visual acuity, and visual field deficits. Visual loss progresses rapidly over days to weeks, and retinal detachment may occur as a late complication.…”

Section: Cytomegalovirus Retinitismentioning

confidence: 99%

Diagnosing HIV-Related disease

Jung

Paauw

1998

J Gen Intern Med

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OBJECTIVE: To summarize current information on the relation between CD4 counts and the risk of different HIV-related diseases. MEASUREMENTS AND MAIN RESULTS: MEDLINE search ofEnglish language articles between 1985 and 1996 using the medical subject heading (MeSH) term "CD4 lymphocyte count" and searches using key words of multiple HIV-related diseases were conducted. Some HIV-related diseases can be stratified to different CD4 count levels. Regardless of their CD4 count, HIV-infected patients are susceptible to sinusitis, Kaposi's sarcoma, community-acquired pneumonia, and oral hairy leukoplakia. In advanced HIV, when CD4 is below 200/ mm 3 , Pneumocystis carinii pneumonia, toxoplasmosis, progressive multifocal leukoencephalopathy, Mycobacterium avium complex, molluscum contagiosum, and bacillary angiomatosis all increase in incidence. In very advanced HIV disease, when CD4 counts are below 50/mm 3 , patients are at risk of pseudomonas pneumonia, cytomegalovirus retinitis, central nervous system lymphoma, aspergillosis, and disseminated histoplasmosis.KEY WORDS: CD4 count; HIV-related disease; risk stratification. J GEN INTERN MED 1998;13:131-136.

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Section: Cytomegalovirus Retinitismentioning

confidence: 99%

Diagnosing HIV-Related disease

Jung

Paauw

1998

J Gen Intern Med

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“…[10][11][12][13] In contrast, CMV disease only becomes evident in late-stage patients when total CD4 T-cell numbers are low. [14][15][16] The underlying mechanism of this temporal hierarchy of immunodeficiency is less clear. Given the importance of the CD4 T-cell response in control of these infections, it has been proposed that memory CD4 populations specific to different opportunistic pathogens are depleted at different rates by HIV.…”

Section: Introductionmentioning

confidence: 99%

Distinct gene-expression profiles associated with the susceptibility of pathogen-specific CD4 T cells to HIV-1 infection

Nau

Ehrenberg

et al. 2013

Blood

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“…[7,8] In our patient without HIV infection, deficiency in humoral and cell-mediated immunity as documented by low counts of CD4 lymphocytes due to immunosuppressive effects of chemotherapeutic agents might have lead to susceptibility for CMV retinitis.…”

Section: Discussionmentioning

confidence: 79%

Bilateral Cytomegalovirus Retinitis in a Child with Rhabdomyosarcoma

Zulfikar¹

2017

TJ Oncol

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SUMMARYReactivation of cytomegalovirus (CMV) leading to retinitis has been commonly reported in association with human immunodeficiency virus (HIV) infection or iatrogenic suppression of the immune system, including transplant recipients. Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in the pediatric age group, and alveolar histology is associated with unfavorable outcome. Presently described is case of RMS with alveolar histology in a 12-year-old male who developed CMV bilateral retinitis during prolonged period of neutropenic fever after 40 weeks of chemotherapy. He was diagnosed based on CMV-DNA polymerase chain reaction in blood and urine samples, and responded well to intravenous gancyclovir treatment. A high index of suspicion for reactivation of CMV leading to retinitis should be maintained and, if needed, investigated, not only in patients with HIV infection or transplant recipients, but also all patients who are iatrogenically immunosuppressed, including those who experience prolonged neutropenic fever due to lengthy courses of radiotherapy and chemotherapy.

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Risk of Developing Cytomegalovirus Retinitis in Persons Infected With the Human Immunodeficiency Virus

Cited by 73 publications

References 0 publications

Diagnosing HIV-Related disease

Diagnosing HIV-Related disease

Distinct gene-expression profiles associated with the susceptibility of pathogen-specific CD4 T cells to HIV-1 infection

Bilateral Cytomegalovirus Retinitis in a Child with Rhabdomyosarcoma

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