Risk of developing an abdominal aortic aneurysm after ectatic aorta detection from initial screening

Identification of a Plasma Microrna Signature as Biomarker of Subaneurysmal Aortic Dilation in Patients with High Cardiovascular Risk

“…In a previous study, we have found that SAD patients already showed increased intima-media values as well as a greater presence of carotid plaques than patients without abdominal aortic dilation. In agreement with our results, it has been reported that men with aortic diameters > 25 mm (SAD) were at increased risk of hypertensive disease, ischemic heart disease, and chronic obstructive pulmonary disease, as well as an increased risk of diabetes mellitus and of heart failure compared with men with an aortic diameter of 24 mm or less [ 11 ]. In addition, the value of plasma D-dimer has been reported to be significantly higher in patients with SAD than in control subjects with a normal diameter of the abdominal aorta, possibly reflecting the presence of microthrombi in the wall of the aorta [ 44 ].…”

“…In addition, aortic tissue can only be obtained from patients at the time of the surgical intervention. The discovery that miRs can be detected in body fluid and that they are very stable led to their proposal as noninvasive biomarkers in many diseases [ 11 ]. Several studies have reported a differential miR expression in plasma and/or in serum between patients with AAA and patients without aortic dilations [ 16 , 17 , 20 , 21 , 22 ].…”

“…All these studies had investigated patients already diagnosed with AAA. Recent evidence indicates that most patients with SAD progress to true AAA [ 9 , 11 ]. Our data demonstrate that some decreased miRs in AAA patients were already reduced in SAD patients in comparison with the levels of these miRs in patients without abnormal aortic dilation.…”

“…Importantly, these patients have a higher risk of all-cause mortality with respect to subjects with aortic size <24 mm [ 9 ]. In addition, both observational and retrospective studies have demonstrated that patients with ectatic aortas are likely to progress and develop an AAA [ 10 , 11 ]. Therefore, the identification of ectatic aortas/subaneurysmal aortic dilatations (SAD) could be considered, not only a parameter of early identification of patients with asymptomatic AAA but also a marker of subclinical end organ damage that could be related to an increased risk of cardiovascular complications.…”

Imminent rupture of abdominal aortic aneurysm complicated by arteriovenous fistulaization and hepatorenal failure: case report and literature review

“…Goergen et al demonstrated that in the infrarenal abdominal aorta, anterior wall displacement is roughly 3.6 times larger than posterior wall displacement, while ultrasound was able to produce a direct measurement with adequate resolution noninvasively (Goergen et al, 2007). Chun et al (2019) reported the ectatic aorta prevalence, AAA development, rupture risk in an AAA screening program, emphasizing the significance of the initial screening. Ultrasound findings have been shown to correlate well with CT imaging (Manning et al, 2009;Scaife et al, 2016).…”