Risk of Developing Adenomas and Carcinomas in the Ileal Pouch in Patients With Familial Adenomatous Polyposis

Friederich, Pieter; Jong, Andrea E. de; Mathus-Vliegen, Lisbeth; Dekker, Evelien; Krieken, Han H J M van; Dees, Jan; Nagengast, Fokko M.; Vasen, Hans F. A.

doi:10.1016/j.cgh.2008.06.011

Cited by 74 publications

(68 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These figures are similar to those reported by Tonelli et al [5] who reported an incidence of 64.9% after 10 years of follow-up, but higher than those reported by Parc et al [6] , Wu et al [7] and Friederich et al [8] who reported an overall incidence of adenomas of 35-45% after a follow-up of 10, 5.5 and 10 years, respectively.…”

Section: Discussionsupporting

confidence: 70%

“…Complete mucosectomy is difficult to achieve, and residual islets of rectal mucosa are found in up to 20% of excised pouches [9,10] . Several studies showed that patients with a double-stapled anastomosis are at increased risk of developing adenomas [8,11,12] . van Duijvendijk et al [11] reported a 3-fold higher risk for developing adenomas in patients with a double-stapled anastomosis compared with those with a hand-sewn anastomosis (31 vs. 10%, respectively).…”

Section: Discussionmentioning

confidence: 99%

“…A number of retrospective studies have investigated risk factors and trends of adenoma reformation [5][6][7][8] , but definitive conclusions and recommendations remain elusive due to the high variance of syndrome presentation and factors affecting the clinical presenta- 424 tion, such as ethnicity, genetic mutations and related extracolonic pathologies.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Patterns of Adenoma Recurrence in Familial Adenomatous Polyposis Patients after Ileal Pouch-Anal Anastomosis

Goldstein¹,

Kariv²,

Klausner³

et al. 2015

Dig Surg

View full text Add to dashboard Cite

Aim: This study aims at identifying the risk factors for the development of pre-cancerous pouch and/or cuff adenomas post ileal pouch anal anastomosis (IPAA) in familial adenomatous polyposis patients. Method: We retrospectively studied 59 patients operated at a single medical center during a 26-year period. Data on the timing and location of adenoma recurrence were recorded and possible correlations with patients' gender, age, presence of desmoid tumor, duodenal adenomas, type of anastomosis and number of operation stages were analyzed. Results: Thirty-five (59%) patients had at least one adenoma in either the cuff or the pouch, including 20 with isolated cuff adenomas, 4 with isolated pouch adenomas and 11 patients with adenomas in both the pouch and cuff. There was no significant correlation between gender, age at surgery, type of anastomosis, number of operative stages and the development of pouch or cuff adenomas. Desmoid tumor and pouch adenomas were significantly correlated with cuff adenomas formation. Duodenal adenomas were associated with pouch adenomas. There was some relationship between the development of cuff adenomas and the burden of colonic polyps, as well as the presence of duodenal adenomas. Conclusion: Adenomas in both the pouch and cuff commonly occur following IPAA, mandating lifelong annual endoscopic surveillance.

show abstract

Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Patterns of Adenoma Recurrence in Familial Adenomatous Polyposis Patients after Ileal Pouch-Anal Anastomosis

Goldstein¹,

Kariv²,

Klausner³

et al. 2015

Dig Surg

View full text Add to dashboard Cite

show abstract

“…Adenomas may develop in the ileal pouch after colectomy with IPAA surgery, or they may develop in the small segment of remaining rectal epithelium after restorative proctocolectomy (175–177). There appears to be a small but real risk for cancer in the ileal pouch (177–179).…”

Section: Lynch Syndrome (Ls)mentioning

confidence: 99%

ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes

Syngal

Brand

Church

et al. 2015

American Journal of Gastroenterology

1,319

1,372

View full text Add to dashboard Cite

This guideline presents recommendations for the management of patients with hereditary gastrointestinal cancer syndromes. The initial assessment is the collection of a family history of cancers and premalignant gastrointestinal conditions and should provide enough information to develop a preliminary determination of the risk of a familial predisposition to cancer. Age at diagnosis and lineage (maternal and/or paternal) should be documented for all diagnoses, especially in first- and second-degree relatives. When indicated, genetic testing for a germline mutation should be done on the most informative candidate(s) identified through the family history evaluation and/or tumor analysis to confirm a diagnosis and allow for predictive testing of at-risk relatives. Genetic testing should be conducted in the context of pre- and post-test genetic counseling to ensure the patient's informed decision making. Patients who meet clinical criteria for a syndrome as well as those with identified pathogenic germline mutations should receive appropriate surveillance measures in order to minimize their overall risk of developing syndrome-specific cancers. This guideline specifically discusses genetic testing and management of Lynch syndrome, familial adenomatous polyposis (FAP), attenuated familial adenomatous polyposis (AFAP), MUTYH-associated polyposis (MAP), Peutz–Jeghers syndrome, juvenile polyposis syndrome, Cowden syndrome, serrated (hyperplastic) polyposis syndrome, hereditary pancreatic cancer, and hereditary gastric cancer.

show abstract

“…En el caso de pacientes sometidos a proctocolectomía total con reservorio ileal, es particularmente importante la vigilancia del reservorio por el alto riesgo de desarrollar adenomas y neoplasias avanzadas 23,24 . El uso de panCE en dicha situación parece aumentar la detección de adenomas.…”

Section: Figura 2 Poliposis Adenomatosa Familiar Colónicaunclassified

Revisión técnica sobre endoscopia avanzada diagnóstica en pacientes con alto riesgo de cáncer colorrectal

Pellisé¹,

Tasende²,

Balaguer³

et al. 2012

Gastroenterología y Hepatología

View full text Add to dashboard Cite

Risk of Developing Adenomas and Carcinomas in the Ileal Pouch in Patients With Familial Adenomatous Polyposis

Cited by 74 publications

References 20 publications

Patterns of Adenoma Recurrence in Familial Adenomatous Polyposis Patients after Ileal Pouch-Anal Anastomosis

Patterns of Adenoma Recurrence in Familial Adenomatous Polyposis Patients after Ileal Pouch-Anal Anastomosis

ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes

Revisión técnica sobre endoscopia avanzada diagnóstica en pacientes con alto riesgo de cáncer colorrectal

Contact Info

Product

Resources

About