Risk of depressive disorders in women undergoing hysterectomy: A population-based follow-up study

Chou, Po-Han; Lin, Ching Heng; Cheng, Chih‐Tao; Chang, Chi‐Sen; Tsai, Chia Jui; Tsai, Ching Pei; Lan, Tsuo Hung; Chan, Chin Hong

doi:10.1016/j.jpsychires.2015.06.017

Cited by 31 publications

(20 citation statements)

References 44 publications

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“…However, the use of different exposure and comparator groups across these studies limit the conclusions that can be made. One study compared women with a bilateral oophorectomy to women without a bilateral oophorectomy (who may or may not have had a hysterectomy) (Rocca et al 2008); the second compared women with a hysterectomy with ovarian conservation with a control group matched for age and physical comorbidity (Chou et al 2015); and the third compared women who had a hysterectomy or endometrial ablation to women who had experienced natural menopause (Dennerstein et al 2004).…”

Section: Introductionmentioning

confidence: 99%

Hysterectomy and incidence of depressive symptoms in midlife women: the Australian Longitudinal Study on Women's Health

Wilson

Pandeya

Byles

et al. 2017

Epidemiol Psychiatr Sci

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Section: Introductionmentioning

confidence: 99%

Hysterectomy and incidence of depressive symptoms in midlife women: the Australian Longitudinal Study on Women's Health

Wilson

Pandeya

Byles

et al. 2017

Epidemiol Psychiatr Sci

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“…Two studies have suggested that women who undergo hysterectomy, regardless of their oophorectomy status, are more distressed than those who do not undergo hysterectomy (Byles, Mishra, & Schofield, 2000;Ceausu, Yasameen, Lidfeldt, Samsioe, & Nerbrand, 2006). A study that analyzed the Taiwanese population records showed that women who underwent hysterectomy exhibited an increased depression risk compared with those who did not, with a hazard ratio of 1.78% and 95% CI between 1.46 and 2.18 (Chou et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Association of hysterectomy with bipolar disorder risk: A population‐based cohort study

et al. 2019

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Background: Hormonal fluctuations may trigger the onset of bipolar disorder. We designed a longitudinal follow-up study to evaluate the association between hysterectomies and bipolar disorder risk. Methods: We conducted a large retrospective cohort study using Taiwan's National Health Insurance Research Database. A total of 4,337 women aged 30 to 50 years who underwent the hysterectomy during 2000-2013 were selected and 17,348 patients without hysterectomy were selected for comparison (1:4 match). Poisson regression analysis was used to calculate the incidence rate ratio (IRR) and 95% confidence interval (CI). Results: During the follow-up of 7.93 years, 20 participants with hysterectomy and 28 without hysterectomy developed bipolar disorder. Receiving hysterectomy was associated with the risk of developing bipolar disorder (adjusted IRR = 2.80; 95% CI = 2.54-3.09). Women with hysterectomy had a higher risk of bipolar disorder in follow-up durations of <1 year (adjusted IRR = 2.18 with 95% CI = 1.94-1.45) and ≥1 year (adjusted IRR = 2.85 with 95% CI = 2.58-3.15). Endometriosis and Premarin use increased bipolar disorder incidence in the hysterectomy group (adjusted IRR = 3.17 [95% CI = 2.83-3.56] and 4.22 [95% CI = 3.71-4.80], respectively). Conclusion: This study concluded that women with hysterectomy have an increased risk of bipolar disorder. Endometriosis and hormone therapy may add to the risk of bipolar disorder after hysterectomy. Knowledge about how surgical or natural hormonal withdrawal influences mood is fundamental and emphasizes the importance of coordinated psychiatric and gynecological care. K E Y W O R D S bipolar disorder, cohort study, epidemiology, hysterectomy, women

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“…Hysterectomy is also a well-established radical procedure for achieving complete cure for symptomatic leiomyomas. However, Yen et al [17] and Chou et al [18] reported that 7.69% of patients experience a depressive disorder after hysterectomy, with previous emotional problems, poor sexual functioning, poor body image, and greater life stress after hysterectomy as risk factors for development of depression. Thus, it is quite reasonable that some patients do not want to undergo hysterectomy even if they do not want to preserve their fertility, and this fact should be considered by gynecologists.…”

Section: Discussionmentioning

confidence: 99%

Unique Learning System for Uterine Artery Embolization for Symptomatic Myoma and Adenomyosis for Obstetrician-Gynecologists in Cooperation with Interventional Radiologists: Evaluation of UAE From the Point of View of Gynecologists Who Perform UAE

Soeda

Hiraiwa

Takata

et al. 2018

Journal of Minimally Invasive Gynecology

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Risk of depressive disorders in women undergoing hysterectomy: A population-based follow-up study

Cited by 31 publications

References 44 publications

Hysterectomy and incidence of depressive symptoms in midlife women: the Australian Longitudinal Study on Women's Health

Hysterectomy and incidence of depressive symptoms in midlife women: the Australian Longitudinal Study on Women's Health

Association of hysterectomy with bipolar disorder risk: A population‐based cohort study

Unique Learning System for Uterine Artery Embolization for Symptomatic Myoma and Adenomyosis for Obstetrician-Gynecologists in Cooperation with Interventional Radiologists: Evaluation of UAE From the Point of View of Gynecologists Who Perform UAE

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