Risk of depression among patients with acne in the U.K.: a population-based cohort study

Vallerand, Isabelle A.; Lewinson, Ryan T.; Parsons, Laurie; Lowerison, Mark; Frolkis, Alexandra; Kaplan, Gilaad G.; Barnabé, Cheryl; Bulloch, Andrew G. M.; Patten, Scott B.

doi:10.1111/bjd.16099

Cited by 46 publications

(47 citation statements)

References 9 publications

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“…Although adolescents are most commonly afflicted by acne, the condition has been reported to affect 10.8% of children between the ages of 5–13 years and 12.7% of adults aged over 59 [ 2 ]. The condition has also been associated with several consequences for more general well-being, including depression [ 3 – 5 ], decreased self-confidence [ 6 ], fatigue [ 7 ], poorer body image satisfaction [ 8 , 9 ], and increased suicidal ideation [ 10 ]. The aspects of the acne experience that contribute most to predicting such impaired well-being have not yet been adequately explored.…”

Section: Introductionmentioning

confidence: 99%

“…In relation to the outcomes in our study, we measure health-related quality of life in terms of self-report of how acne impacts participants’ quality of life, as in prior studies on skin conditions [ 25 , 28 – 29 ]. We operationalize psychological distress as a composite of the participants’ anxiety and depression levels, as acne sufferers have been documented to exhibit increased anxiety and depression in comparison to non-sufferers [ 4 – 5 , 21 ]. In line with previous research [ 44 – 45 ], physical health is operationalized by assessing self-reported somatic symptoms.…”

Section: Introductionmentioning

confidence: 99%

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Stigma predicts health-related quality of life impairment, psychological distress, and somatic symptoms in acne sufferers

Davern

O’Donnell

2018

PLoS ONE

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Acne vulgaris has been associated with deficits in psychological well-being and health-related quality of life. Few studies have investigated how stigma contributes to our understanding of the well-being of acne sufferers, although it is clear that acne is stigmatized and stigmatization is associated with impaired well-being. The current study aimed to investigate the ability of perceived stigma to predict health-related quality of life, psychological distress, and somatic symptoms over and above established predictors. University students and staff suffering from acne completed self-report measures online. Hierarchical multiple regression analyses showed that perceived stigma significantly contributed to the prediction of all three well-being measures, over and above the effects of gender, acne severity, acne location, and use of medication. Indeed, perceived stigma made the largest unique contribution to predicting well-being. Our findings suggest that interventions that attempt to counter stigma could also improve the overall well-being of people affected by acne.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stigma predicts health-related quality of life impairment, psychological distress, and somatic symptoms in acne sufferers

Davern

O’Donnell

2018

PLoS ONE

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“…The mechanisms for the increased admission rates for MH disorders in patients with acne or rosacea are unknown. Acne and rosacea have been found to be associated with increased rates of personality disorders and/or mood disorders, including depression and anxiety . It may be that more severe acne and rosacea are associated with severe MH symptoms, warranting clinical hospitalization.…”

Section: Discussionmentioning

confidence: 99%

“…Acne and rosacea have been found to be associated with increased rates of personality disorders and/or mood disorders, including depression and anxiety. [19][20][21] It may be that more severe acne and rosacea are associated with severe MH symptoms, warranting clinical hospitalization. A complex interaction of cutaneous and gut microbiome has been proposed to have an impact on acne severity and potentially influence systemic inflammation, oxidative stress, glycaemic control and ultimately MH symptoms.…”

Section: Discussionmentioning

confidence: 99%

The mental health burden in acne vulgaris and rosacea: an analysis of the US National Inpatient Sample

et al. 2019

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Summary Background Little is known about the mental health (MH) hospitalization among patients with acne and rosacea. Aims To determine the MH disorders and cost burden associated with acne and rosacea. Methods Data were examined from the 2002–2012 US National Inpatient Sample, comprising a sample of ~20% of all US paediatric and adult hospitalizations (n = 87 053 155 admissions). Results A diagnosis of ≥ 1 MH disorder was much more common among all inpatients with vs. those without a diagnosis of acne (43.7% vs. 20.0%, respectively) and rosacea (35.1% vs. 20.0%, respectively). In multivariable logistic regression models controlling for sex, age, race/ethnicity and insurance status, acne (adjusted OR = 13.02; 95% CI 11.75–14.42) and rosacea (adjusted OR = 1.70; 95% CI 1.56–1.95) were associated with significantly higher odds of a primary admission for an MH disorder (13 and 8, respectively, of 15 MH disorders examined). Both acne and rosacea were associated with higher risk of mood, anxiety, impulse control and personality disorders, and with > $2 million of excess mean annual costs of hospitalization for MH disorders in the USA. Conclusion In this study, inpatients with acne or rosacea had increased odds of comorbid MH disorders. In particular, there was an increased number of hospital admissions secondary to a primary MH disorder with coexistent acne/rosacea. MH comorbidities were associated with considerable excess costs among inpatients with acne or rosacea.

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“…Although we concluded in our study that 'it is critical that physicians monitor mood symptoms in patients with acne', we did not recommend formal screening for depression in people with acne and believe it is important to draw a distinction between a formal screening program vs. symptom monitoring. 2 Screening entails the early detection of established disease. 3 In the context of depression, screening identifies patients with depression who have not yet been detected or sought treatment, 4 usually by standardized questionnaire.…”

Section: Is Depression Screening In Patients With Acne Critical?: Repmentioning

confidence: 99%

Is depression screening in patients with acne critical?: reply from authors

et al. 2018

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Risk of depression among patients with acne in the U.K.: a population-based cohort study

Cited by 46 publications

References 9 publications

Stigma predicts health-related quality of life impairment, psychological distress, and somatic symptoms in acne sufferers

Stigma predicts health-related quality of life impairment, psychological distress, and somatic symptoms in acne sufferers

The mental health burden in acne vulgaris and rosacea: an analysis of the US National Inpatient Sample

Is depression screening in patients with acne critical?: reply from authors

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