Risk of Delayed Human Papillomavirus Vaccination in Inner-City Adolescent Women

Díaz, Ángela; Shankar, Viswanathan; Szporn, Arnold H.; Wu, Maoxin; Nucci-Sack, Anne; Peake, Ken; Strickler, Howard D.; Burk, Robert D.

doi:10.1093/infdis/jiw486

Cited by 14 publications

(17 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 In a recent longitudinal study of sexually active adolescent females (aged 13-21 years) in a U.S. inner city, there was a 78% reduction in quadrivalent vaccine-type HPV incidence associated with being fully vaccinated versus unvaccinated. 16 We also note that the incidence of vaccine-type HPV in our partially vaccinated cohort was lower than in 15-to 25-year-old women enrolled in the placebo arms of HPV vaccine trials. For example, whereas the incidence of HPV-16 was 4.4 per 100 person-years in our study, placebo-arm incidence of HPV-16 was 5.9…”

Section: Methodsmentioning

confidence: 50%

“…Among 14‐ to 24‐year‐old females participating in the 2009‐2012 NHANES, self‐reported history HPV vaccination (≥1 dose) was associated with a reduction in vaccine‐type HPV prevalence (16, 18, 6, 11) of 89% . In a recent longitudinal study of sexually active adolescent females (aged 13‐21 years) in a U.S. inner city, there was a 78% reduction in quadrivalent vaccine‐type HPV incidence associated with being fully vaccinated versus unvaccinated . We also note that the incidence of vaccine‐type HPV in our partially vaccinated cohort was lower than in 15‐ to 25‐year‐old women enrolled in the placebo arms of HPV vaccine trials.…”

Section: Discussionmentioning

confidence: 59%

“…6 HPV L1 consensus primers MY09, MY11, and HMB01 and β-globin primers PC04 and GH2 were used to simultaneously amplify HPV DNA and β-globin. Samples that were HPV positive by generic probe or β-globin negative were typed with the Roche Linear Array HPV genotyping test (Roche Molecular Systems, Inc, Alameda, CA) for 37 HPV types, including 21 clinically relevant types: HPV types 6 and 11 (due to their association with genital warts 9,10 ) and 19 oncogenic types classified as carcinogenic, probably carcinogenic, or possibly carcinogenic: 16,18,26,31,33,35,39,45,51,52,53,56,58,59,66,68,73,82,IS39 11,12 Samples that were β-globin negative during the initial dot blot step and HPV negative by the Roche assay were considered insufficient.…”

Section: Methodsmentioning

confidence: 99%

“…Among 15-to 25-year-old women included in the intent-to-treat analysis of the bivalent HPV vaccine trial, vaccine effectiveness against incident HPV-16 or HPV-18 was 68%. 15 Among 14-to 24-year-old females participating in the 2009-2012 NHANES, self-reported history HPV vaccination (≥1 dose) was associated with a reduction in vaccine-type HPV prevalence (16,18,6,11) of 89%. 5 In a recent longitudinal study of sexually active adolescent females (aged 13-21 years) in a U.S. inner city, there was a 78% reduction in quadrivalent vaccine-type HPV incidence associated with being fully vaccinated versus unvaccinated.…”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Incidence and risk factors for human papillomavirus infections in young female online daters

Stern

Feng³

et al. 2017

J Med Virol

View full text Add to dashboard Cite

Risk factors for incident HPV infections are undefined in young women who use internet dating Web sites. From 2010–2012 we followed 18–24-year-old female internet daters (N=164) triannually for a mean of one year. Women collected and returned self-collected vaginal samples for HPV genotyping and health and behavior questionnaires. We used Kaplan-Meier methods to estimate incidence of clinically-relevant HPV infection (high- risk HPV, HPV-6, or HPV-11) and generalized estimating equations and Firth logistic regression to identify associated risk factors. At enrollment, women reported a median lifetime number of 6 male sex partners, and 36% reported a history of HPV vaccination. The 12-month cumulative incidence of clinically-relevant HPV was 32.9% (95%CI:26.0%–41.0%). Reporting a recent male sex partner met via the internet versus not was not significantly associated with incident HPV (odds ratio [OR]=0.91, 95%CI:0.53–1.55). In multivariate analysis adjusted for lifetime number of partners, reporting new and/or multiple partners in the past 6 months was positively associated with incident HPV (OR=6.38, 95%CI:1.56–26.02, compared to reporting no recent partners). In a separate model, self-reporting ≥1 dose of HPV vaccine was inversely associated with vaccine-type HPV (6/11/16/18) (OR=0.21, 95%CI:0.05–0.86), but the association was attenuated and not statistically significant after adjusting for sexual history (OR=0.36, 95%CI:0.09–1.43). While recent high-risk sexual behavior was associated with incident HPV, sex with partners met via the internet was not associated with increased HPV risk in young female internet daters. Although not statistically significant after adjusting for sexual history, HPV vaccination showed substantial protection against vaccine-type HPV infection. This article is protected by copyright. All rights reserved

show abstract

Section: Methodsmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 59%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Incidence and risk factors for human papillomavirus infections in young female online daters

Stern

Feng³

et al. 2017

J Med Virol

View full text Add to dashboard Cite

show abstract

“…If the patient was under age 18, consent was also obtained from their parent or legal guardian. Participants then completed a study questionnaire regarding sociodemographics, risk behaviors, and vaccination history that was modified from a questionnaire used in prior study of HPV infection [14][15]. Participants were instructed to avoid consulting their parents for answers to survey questions until they submitted the questionnaire.…”

Section: Methodsmentioning

confidence: 99%

Recall of Human Papillomavirus (HPV) Vaccination History among Adolescents

Thompson¹

2014

J Vaccines Vaccin

View full text Add to dashboard Cite

Objective: Data examining the accuracy of patients' ability to recall their HPV vaccination history are sparse and conflicting, and generally suggest that adolescents often report this information inaccurately. This study aims to elucidate accuracy of HPV vaccination recall among a diverse sample of female and male adolescents. Methods: Adolescents (N=224, ages 12-23) recruited from a large military primary care clinic completed a questionnaire regarding sociodemographics, clinical variables, and HPV vaccination history. Electronic databases were searched to determine each participant's recorded vaccination history. Accuracy of recall was calculated for initiation and completion of the series; and age-and gender-based comparisons were conducted. Results: 224 adolescents aged 12-23 enrolled in the study; 217 provided complete data. Electronic records showed that 59.5% of the adolescents initiated, whereas 40.1% completed the 3-shot series. Of the 217 participants, 65.9% correctly recalled initiation (or lack of initiation) and 56.2% correctly recalled completion (or lack of completion). In bivariate analysis, older adolescents had more accurate recall of initiation compared to younger adolescents (p<0.002); however, there was no difference between gender (P<0.195), race (P<0.104), or sexual debut (P<0.196). Furthermore, 40.5% of adolescents who have had vaginal, oral, or anal intercourse completed the series. Conclusion: Among adolescents in a diverse, vaccination-centric clinical setting, recall of HPV-related vaccination status is often inaccurate, and should be interpreted with caution. The level of inaccuracy found in this study, which is consistent with prior studies, has important implications for clinicians and researchers who depend on self-reporting of vaccination status for vaccine-related efforts.

show abstract