Risk of defeats in the central nervous system during deep space missions

Kokhan, V. S.; Matveeva, M. I.; Mukhametov, Azat; Штемберг, А. С.

doi:10.1016/j.neubiorev.2016.10.006

Cited by 38 publications

(32 citation statements)

References 100 publications

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“…Ионизирующее излучение (ИИ), представленное прежде всего тяжёлыми заряженными частицами высоких энергий (ТЗЧ), является одним из основных лимитирующих факторов пилотируемых дальних космических миссий [1]. Несмотря на интенсивные исследования, влияние умеренных доз ТЗЧ на ЦНС остаётся малоизученным.…”

Section: физиологияunclassified

“…Эти данные хорошо согласуются с ранее выявленным ростом числа апоптических клеток в ответ на действие ИИ [10]. Нарушению гиппокампального нейрогенеза в ответ на действие ИИ всецело опосредовано воспалительной реакцией нервной ткани [1]. Вместе с тем альтерации HPA-системы ассоциированы со снижением экспрессии нейротрофического фактора мозга в гиппокампе [11].…”

Section: результаты исследованияunclassified

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Combined irradiation by gamma rays and carbon nuclei increases the C/EBP-β LIP-isoform content in the pituitary gland of rats

Anokhina

Анохин

Kokhan

2019

Доклады Академии наук

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C/EBP-β, a basic leucine zipper transcription factor, has important roles in the regulation of organism’s immune and inflammatory responses. Wistar rats subjected to the combined irradiation were characterized by an increase in the content of C/EBP-β LIP-isoform in the pituitary gland. The obtained data indicate that moderate doses of ionizing radiation to initiate the endoplasmic reticulum stress response and are likely to initiate C/EBP-β-mediated cell death according to the apoptotic scenario. This study also confirms the earlier hypothesis about the alterations of the hypothalamic-pituitary-adrenocortical axis in response to moderate doses of ionizing radiation.

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Section: физиологияunclassified

Section: результаты исследованияunclassified

Combined irradiation by gamma rays and carbon nuclei increases the C/EBP-β LIP-isoform content in the pituitary gland of rats

Anokhina

Анохин

Kokhan

2019

Доклады Академии наук

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“…Perturbations of and risks of defects in central nervous system [CNS] function may be achieved by microgravity, magnetic fields and exposure to ionizing radiation [43,44]. Effects of radiation on the CNS have been studied using non-clinical model systems from particle accelerators simulating space radiation and can be gleaned by systematically reviewing CNS effects on cancer patients who have received radiotherapy and subjects who have been exposed to radiation through nuclear warfare.…”

Section: Neuronal and Neurovestibularmentioning

confidence: 99%

Ergonomic Challenges for Astronauts during Space Travel and the Need for Space Medicine

Braddock¹

2017

J Ergonomics

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“…Magnetic fields in inter-planetary space and on Mars and the Moon are at least ten times weaker than Earth's geomagnetic field (GMF) (Kokhan et al, 2016). Such weak fields are often called hypo-magnetic fields (HMFs).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Effects of Hypo-Magnetic Fields on Mouse Macrophage RAW264 Cells

Srimai¹,

Kiatarkom²,

Miyata³

2020

IJC

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Hypo-magnetic fields (HMFs) are static magnetic fields that are significantly weaker than the geomagnetic field and are found in interplanetary space, on Mars, and the Moon. Understanding the mechanism of the biological effects of HMFs is an important topic in magnetobiology. Human physiology studies have shown that HMFs cause various adverse health effects such as increased blood pressure and blood flow rate. Previous studies on the effects of HMFs on cells revealed a variety of effects, such as a change in growth rate, a decrease in mitochondrial membrane potential, and an increase in reactive oxygen species. A decrease in mitochondrial membrane potential (DFm) may seriously impair cellular activity by interfering with the production of ATP. Thus, a deeper investigation of the effects of HMFs on mitochondrial function could provide clues to understanding the adverse effects of HMFs. In the present study, we used mouse macrophage RAW264 cells to investigate the effects of an HMF on mitochondrial membrane potential, mitochondrial superoxide anion (O2-) production, and cell proliferation.

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Risk of defeats in the central nervous system during deep space missions

Cited by 38 publications

References 100 publications

Combined irradiation by gamma rays and carbon nuclei increases the C/EBP-β LIP-isoform content in the pituitary gland of rats

Combined irradiation by gamma rays and carbon nuclei increases the C/EBP-β LIP-isoform content in the pituitary gland of rats

Ergonomic Challenges for Astronauts during Space Travel and the Need for Space Medicine

Evaluation of the Effects of Hypo-Magnetic Fields on Mouse Macrophage RAW264 Cells

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