Risk of COVID-19 in health-care workers in Denmark: an observational cohort study

Iversen, Kasper; Bundgaard, Henning; Hasselbalch, Rasmus Bo; Kristensen, Jonas Henrik; Nielsen, Pernille B; Pries-Heje, Mia Marie; Knudsen, Andreas Dehlbæk; Christensen, Casper Emil; Fogh, Kamille; Norsk, Jakob; Andersen, Ove; Fischer, Thea Kølsen; Jensen, Claus Antonio Juul; Larsen, Margit Hørup; Torp‐Pedersen, Christian; Rungby, Jørgen; Ditlev, Sisse B.; Hageman, Ida; Møgelvang, Rasmus; Hother, Christoffer; Gybel-Brask, Mikkel; Sørensen, Erik; Harritshøj, Lene Holm; Folke, Fredrik; Sten, Curt; Benfield, Thomas; Nielsen, Susanne Dam; Ullum, Henrik

doi:10.1016/s1473-3099(20)30589-2

Cited by 402 publications

(558 citation statements)

References 18 publications

(30 reference statements)

Supporting

Mentioning

437

Contrasting

Unclassified

Order By: Relevance

“…In conclusion, HCWs in this study were at modestly lower risk for SARS-CoV-2 infection as compared with other studies of HCWs from the New York area and Spain, and similar seropositive rates as reported in Denmark [ 4 , 22 , 23 ]. Across occupation groups, nurses were at the highest-level risk from work-related exposures.…”

Section: Discussionsupporting

confidence: 85%

Seroprevalence and Correlates of SARS-CoV-2 Antibodies in Health Care Workers in Chicago

Wilkins

Gray

Wallia

et al. 2020

Open Forum Infectious Diseases

View full text Add to dashboard Cite

Background Identifying factors associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among health care workers (HCWs) may help health systems optimize SARS-CoV-2 infection control strategies. Methods We conducted a cross-sectional analysis of baseline data from the Northwestern HCW SARS-CoV-2 Serology Cohort Study. We used the Abbott Architect Nucleocapsid IgG assay to determine seropositivity. Logistic regression models (adjusted for demographics and self-reported community exposure to coronavirus disease 2019 [COVID-19]) were fit to quantify the associations between occupation group, health care delivery tasks, and community exposure and seropositive status. Results A total of 6510 HCWs, including 1794 nurses and 904 non-patient-facing administrators, participated. The majority were women (79.6%), 74.9% were White, 9.7% were Asian, 7.3% were Hispanic, and 3.1% were non-Hispanic Black. The crude prevalence of seropositivity was 4.8% (95% CI, 4.6%–5.2%). Seropositivity varied by race/ethnicity as well as age, ranging from 4.2% to 9.6%. Out-of-hospital exposure to COVID-19 occurred in 9.3% of HCWs, 15.0% (95% CI, 12.2%–18.1%) of whom were seropositive; those with family members diagnosed with COVID-19 had a seropositivity rate of 54% (95% CI, 44.2%–65.2%). Support service workers (10.4%; 95% CI, 4.6%–19.4%), medical assistants (10.1%; 95% CI, 5.5%–16.6%), and nurses (7.6%; 95% CI, 6.4%–9.0%) had significantly higher seropositivity rates than administrators (referent; 3.3%; 95% CI, 2.3%–4.4%). However, after adjustment, nursing was the only occupation group with a significantly higher odds (odds ratio, 1.9; 95% CI, 1.3–2.9) of seropositivity. Exposure to patients receiving high-flow oxygen therapy and hemodialysis was significantly associated with 45% and 57% higher odds for seropositive status, respectively. Conclusions HCWs are at risk for SARS-CoV-2 infection from longer-duration exposures to people infected with SARS-CoV-2 within health care settings and their communities of residence.

show abstract

Section: Discussionsupporting

confidence: 85%

Seroprevalence and Correlates of SARS-CoV-2 Antibodies in Health Care Workers in Chicago

Wilkins

Gray

Wallia

et al. 2020

Open Forum Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…These rates are significantly higher than those found within the general population (38.5% and 30.4%, respectively, according to a recent meta-analysis) 9 and equally considerably higher when compared to HCW prevalence rates in the United States 11,12 or in other European countries. 13,14 In addition, a higher rate of dysgeusia was particularly highlighted in our European cohort which had not been previously described. The higher prevalence rates of both olfactory and taste disturbance are unexpected when T A B L E 4 Influence of available variables on recovery rate in the population of health care workers who experienced smell and/or taste dysfunction First Symptom P = .6 P = .9 P = .7 P = .6 P = .7 P = .9…”

Section: Discussionsupporting

confidence: 43%

Olfactory and taste dysfunction among mild‐to‐moderate symptomatic COVID‐19 positive health care workers: An international survey

Andrews

Pendolino

Ottaviano

et al. 2020

Laryngoscope Investig Oto

View full text Add to dashboard Cite

Objectives To determine the prevalence of olfactory and taste dysfunction (OD; TD) among COVID‐19 positive health care workers (HCWs), their associated risk factors and prognosis. Methods Between May and June 2020, a longitudinal multicenter study was conducted on symptomatic COVID‐19 PCR confirmed HCWs (COVID‐19 positive) in London and Padua. Results Hundred and fourteen COVID‐19 positive HCWs were surveyed with a response rate of 70.6% over a median follow‐up period of 52 days. UK prevalence of OD and TD was 73.1% and 69.2%, respectively. There was a male to female ratio of 1:3 with 81.6% being white, 43.7% being nurses/health care assistants (HCAs), and 39.3% being doctors. In addition, 53.2% of them worked on COVID‐19 wards. Complete recovery was reported in 31.8% for OD and 47.1% for TD with a 52 days follow‐up. The job role of doctors and nurses negatively influenced smell ( P = .04 and P = .02) and taste recovery ( P = .02 and P = .01). Ethnicity (being white) showed to positively influence only taste recovery ( P = .04). Sex (being female) negatively influenced OD and TD recovery only in Paduan HCWs ( P = .02 and P = .011, respectively). Working on a COVID‐19 ward did not influence prognosis. Conclusions The prevalence of OD and TD was considerably higher in HCWs. The prognosis for OD and TD recovery was worse for nurses/HCAs and doctors but working on a COVID‐19 ward did not influence prognosis. Sixty‐eight percent of surveyed HCWs at 52 days continued to experience OD or TD requiring additional future medical management capacity. Level of Evidence 4.

show abstract

“…This suggests a risk similar to that of the general Danish population (1 July 12 831 COVID-19 infected/total population 5.8 mill=0.22%) ( www.SSI.dk ). 15 Similarly, previous studies have found no evidence of an overrepresentation of patients with inflammatory rheumatic disease among SARS-CoV-2 infected. 2–4 …”

Section: Discussionmentioning

confidence: 78%

Self-protection strategies and health behaviour in patients with inflammatory rheumatic diseases during the COVID-19 pandemic: results and predictors in more than 12 000 patients with inflammatory rheumatic diseases followed in the Danish DANBIO registry

et al. 2021

View full text Add to dashboard Cite

AimsIn Danish patients with inflammatory rheumatic diseases to explore self-protection strategies and health behaviour including adherence to disease-modifying antirheumatic treatment (DMARD) during the initial phase of the COVID-19 pandemic and again after the reopening of the society started. Furthermore, to identify characteristics of patients with high levels of anxiety and self-isolation.MethodsPatients in routine care followed prospectively in the nationwide DANBIO registry were invited to answer an online questionnaire regarding disease activity and COVID-19 infection, behaviour in March and June 2020. Responses were linked to patient data in DANBIO. Characteristics potentially associated with anxiety, self-isolation and medication adherence (gender/age/diagnosis/education/work status/comorbidity/DMARD/smoking/EQ-5D/disease activity) were explored with multivariable logistic regression analyses.ResultsWe included 12 789 patients (8168 rheumatoid arthritis/2068 psoriatic arthritis/1758 axial spondyloarthritis/795 other) of whom 65% were women and 36% treated with biological DMARD. Self-reported COVID-19 prevalence was 0.3%. Patients reported that they were worried to get COVID-19 infection (March/June: 70%/45%) and self-isolated more than others of the same age (48%/38%). The fraction of patients who changed medication due to fear of COVID-19 were 4.1%/0.6%. Female gender, comorbidities, not working, lower education, biological treatment and poor European Quality of life, 5 dimensions were associated with both anxiety and self-isolation.ConclusionIn >12 000 patients with inflammatory arthritis, we found widespread anxiety and self-isolation, but high medication adherence, in the initial phase of the COVID-19 pandemic. This persisted during the gradual opening of society during the following months. Attention to patients’ anxiety and self-isolation is important during this and potential future epidemics.

show abstract

Risk of COVID-19 in health-care workers in Denmark: an observational cohort study

Cited by 402 publications

References 18 publications

Seroprevalence and Correlates of SARS-CoV-2 Antibodies in Health Care Workers in Chicago

Seroprevalence and Correlates of SARS-CoV-2 Antibodies in Health Care Workers in Chicago

Olfactory and taste dysfunction among mild‐to‐moderate symptomatic COVID‐19 positive health care workers: An international survey

Self-protection strategies and health behaviour in patients with inflammatory rheumatic diseases during the COVID-19 pandemic: results and predictors in more than 12 000 patients with inflammatory rheumatic diseases followed in the Danish DANBIO registry

Contact Info

Product

Resources

About