Risk of coronavirus disease 2019 (COVID-19) infection on leukemia patients: basic science to clinical aspect ‎

Sumantri, Agung Firmansyah; Bashari, Muhammad Hasan; Tadjoedin, Hilman; Atik, Nur

doi:10.51847/qqiktbahb7

Cited by 9 publications

(2 citation statements)

References 59 publications

(74 reference statements)

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“…It is well known that SARS CoV-2 Spike protein interacts with ACE2 in the receptor binding phase to begin internalization [15]. This is supported by the fact that leukaemia patients, which have increased ACE2 expression levels, have an increased risk of COVID-19 infection and more severe disease manifestation [16]. However, the differences in endosomal RAB5, RAB7, and RAB11B mRNA expression between positive and negative covid-19 patients are still unknown.…”

Section: Open Accessmentioning

confidence: 99%

Differences in endosomal Rab gene expression between positive and negative COVID-19 patients

et al. 2022

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Objective SARS CoV-2, the etiologic agent of coronavirus disease-2019 (COVID-19) is well-known to use ACE2 to begin internalization. Some viruses enter the host cell through the endocytosis process and involve some endocytosis proteins, such as the Rab family. However, the relationship between SARS CoV-2 infection with endocytic mRNA RAB5, RAB7, and RAB11B is unknown. This study aims to compare the expression of RAB5, RAB7, and RAB11B between positive and negative COVID-19 patient groups. Results Both viral and human epithelial RNA Isolation and RT-PCR were performed from 249 samples. The genes expression was analysed using appropriate statistical tests. We found the Median (inter-quartile range/IQR) of RAB5, RAB7, and RAB11B expression among the COVID-19 patient group was 2.99 (1.88), 0.17 (0.47), 0.47 (1.49), and 1.60 (2.88), 1.05 (2.49), 1.10 (3.96) among control group respectively. We proceeded with Mann Whitney U Test and found that RAB5 expression was significantly increased (P < 0.001), and RAB7 and RAB11B expression was significantly decreased (P < 0.001 and P = 0.036) in the COVID-19 patient group compared to the control group. This first report showed significant differences in RAB5, RAB7, and RAB11B exist between COVID-19 positive and negative patients.

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Section: Open Accessmentioning

confidence: 99%

Differences in endosomal Rab gene expression between positive and negative COVID-19 patients

et al. 2022

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“…This VOC was linked to greater transmissibility, enhanced infectivity, and possibly higher re-infection rates than the Delta variation, as well as a stronger affinity for human ACE2 (Kumar et al, 2021;WHO, 2021). High levels of ACE2 leads to higher risks of getting COVID-19, especially people with immune system defects (Sumantri et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Intravenous Vitamin C (Ivc) Treatment Outcome of Covid 19 Patients Admitted in Hospital: A Systematic Review

et al. 2023

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Background: Coronavirus disease 2019 (COVID-19) is still becoming a problem in several countries with the emergence of new variants with the latest variant named Omicron. Studies show that patients with COVID-19 tend to have Acute Respiratory Distress Syndrome (ARDS) because of high pro-inflammatory cytokines and chemokines levels. Since its role as an antiviral agent, anti-cytokine, immunomodulator, antioxidant and has potential effect in maintaining body functions, vitamin C can be used as one of therapy. There is still arguable about giving treatment of COVID-19 patients with Intravenous Vitamin C (IVC). Previous research has not been discussed related to accelerating recovery and decreasing mortality. Purpose: To identify the impact of IVC intervention given to COVID-19 patients admitted in hospital by reviewing clinical outcomes particularly on complexity or mortality. Review: Literature information was sourced from PubMed, ScienceDirect, and Google Scholar databases through keywords to retrieve inclusion criteria published during 2019-2021. Result: We found that IVC influenced inflammatory biomarkers such as CRP, d-dimer, ferritin, and several inflammatory cytokines, mortality, length of stay, oxygenation, organ and immune system function but showed no significant difference between the control group. Conclusion: IVC treatment might be an essential adjuvant therapy in the aggravation of mild, severe, and critical COVID-19 patients, but did not understate complexity or mortality. Hence, further research and evaluation in clinical trials are needed.

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Study of the Permeability of Blood-Aqueous Barrier with Tetracycline Group Drugs in Normal and Pathological Conditions

Chochaeva,

Malinovskaia,

Guchakova

et al. 2023

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Risk of coronavirus disease 2019 (COVID-19) infection on leukemia patients: basic science to clinical aspect ‎

Cited by 9 publications

References 59 publications

Differences in endosomal Rab gene expression between positive and negative COVID-19 patients

Differences in endosomal Rab gene expression between positive and negative COVID-19 patients

Intravenous Vitamin C (Ivc) Treatment Outcome of Covid 19 Patients Admitted in Hospital: A Systematic Review

Study of the Permeability of Blood-Aqueous Barrier with Tetracycline Group Drugs in Normal and Pathological Conditions

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