“…[1][2][3][4] Patients with a diagnosis of implant-related ALCL have had implants that were either ruptured or intact, filled either with saline or with silicone gel, and placed for either reconstructive or cosmetic purposes; these varying circumstances have not appeared to make any difference. 5,6 Although large observational epidemiological studies in North American and Scandinavian women have disproved significant associations with breast cancer or other specific cancer sites or with autoimmune disease, [11][12][13][14][15][16][17] currently, clinical and histological findings of two major reviews 5,6 speak in favor of an association between breast implants and ALK-1-negative ALCL, which presumably is an indolent form of this group of non-Hodgkin's lymphoma that is completely distinct from the systemic disease with a clinical behavior more similar to primary cutaneous ALCL than to the systemic counterpart. Thus, several authors agree that implant-related ALCL should be recognized as a separate category in the World Health Organization's classification, with its own diagnosis and treatment.…”