Risk of congenital anomalies near the Byker waste combustion plant

Cresswell, Penny; Scott, J. E.; Pattenden, Sam; Vrijheid, Martine

doi:10.1093/pubmed/fdg053

Cited by 14 publications

(18 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NTD, cardiovascular, and abdominal wall defects; hypospadias and epispadias; surgical correction of hypospadias and epispadias; surgical correction of gastroschisis and exomphalos; Birth outcome. LBW; LBW, Stillbirths Landfill site Mother exposure defined as residential postcodes within 2 km buffer zone around each siteYear of birth, sex deprivationModel prediction from poisson regressionNo statistically significant excess risks of adverse pregnancy outcomes (LBW, stillbirth, Congenital anomalies) detected in population living within 2 km of a hazardous waste siteCresswell et al 2003 [24]Ecologic study in city of New Castle upon Tyne, 85–99United Kingdom Specific defects Chromosomal and non-chromosomal defects Waste combustion plant Mother’s exposure defined as residence within 3 km of Byker waste combustion plantED-level deprivationNot able to adjust for other characteristicsPoisson regressions used to estimate Rate ratios for congenital anomalyLittle evidence of relation between prevalence of congenital malformations and residence near waste combustion plantKloppenbor et al 2005 [26]Ecological study in Denmark, 1997–2001DenmarkAll congenital anomalies combined Specific defects The nervous or cardiovascular systems in live births Landfill Three buffer zones: 0–2 (proximal zone), 2–4 (middle zone), and 4–6 km (distal zone) was constructed surrounding waste landfill sites–The risk rate (RR) was calculated by dividing the sum of congenital anomaly (or specific defects) by total proximal sum of birthsNo association found between maternal residential proximity to landfills and all congenital malformations combined or of the nervous system. However, the result noted small excess risk for anomalies of the cardiovascular systemBentov et al 2006 [57]Ecologic study of live births and stillbirthsBeer-Sheva subdistrict1995–2000 IsraelMajor congenital malformations combined Specific defects Central nervous system, chromosomal anomalies and other major congenital malformations Industrial park Distance of localities from regional industrial park and predominant wind directionCalculation of rateby dividing the number of newborns born with birth defect by the number of deliveriesResidential proximity to industrial park associated with increased rates of major congenital malformations among Bedouin populationsJarup et al 2007 a [49]Ecologic study of England and Wales 1989–1998Great Britain Specific defects Down syndrome Landfill site Mother exposure defined as an residential address within 2-km zone of a landfill site…”

Section: Methodsmentioning

confidence: 99%

“…Most studies were conducted in the United States (18) [12, 13, 22, 23, 27–40] and the UK (14) [11, 21, 24, 25, 41–50]. We also found five studies conducted in continental Europe [1, 26, 51–53], two in Canada [54, 55] and two in Asia [56, 57] investigating whether living near a polluted site increases the risk of adverse reproductive outcome.…”

Section: Bibliographic Materialsmentioning

confidence: 99%

“…With the exception of a single descriptive geographical study [25] and eleven ecological studies [11, 21, 24, 27, 28, 45, 47–49, 53, 57], all papers analysed individual data, including ten cohort studies [29, 36, 42–44, 46, 50, 55, 56] and 18 case–control studies [1, 12, 13, 22, 23, 30–35, 37–40, 51, 52, 54]. Most databases were drawn from either congenital registers or birth certificates (see Table 3).…”

Section: Bibliographic Materialsmentioning

confidence: 99%

“…The first category, in number, is congenital malformations, encompassing studies of all congenital abnormalities combined [1, 11–13, 21–26, 30–39, 41, 45–48, 50, 52, 55, 57], specific abnormalities such as heart defects [1, 11–13, 22, 23, 26, 31, 34–36, 45–47, 52, 55], neural tube defects (NTD) [1, 11, 12, 35, 39, 45, 47, 52, 55], central nervous system abnormalities [12, 23, 26, 36–38, 52, 57], oral defects [11, 12, 23, 35, 37, 41, 45, 47, 52], chromosomal abnormalities [12, 13, 24, 33, 34, 37, 46, 49–51, 55, 57] and lethal congenital abnormalities [42–44, 56]. The second most investigated category of outcome encompassed low birth weight (LBW) [21, 23, 27–30, 45, 47, 48, 50, 53–56], preterm birth (PTB) [27, 29, 53–55], small for gestational age (SGA) [53, 54] and intrauterine growth retardation (IUGR) [29, 55].…”

Section: Bibliographic Materialsmentioning

confidence: 99%

See 3 more Smart Citations

Systematic literature review of reproductive outcome associated with residential proximity to polluted sites

et al. 2017

View full text Add to dashboard Cite

This study aims to assess the evidence on adverse pregnancy outcome associated with living close to polluted industrial sites, and identify the strengths and weaknesses of published epidemiological studies. A systematic literature search has been performed on all epidemiological studies published in developed countries since 1990, on the association between residential proximity to industrial sites (hazardous waste sites, industrial facilities and landfill sites) and adverse pregnancy outcome (low birth weight, preterm birth, small for gestational age, intrauterine growth retardation, infant mortality, congenital malformation). Based on 41 papers, our review reveals an excess risk of reproductive morbidity. However, no studies show significant excess risk of mortality including fetal death, neonatal or infant mortality and stillbirth. All published studies tend to show an increased risk of congenital abnormalities, yet not all are statistically significant. All but two of these studies revealed an excess risk of low birth weight. Results for preterm birth, small for gestational age and intrauterine growth retardation show the same pattern. There is suggestive evidence from the post-1990 literature that residential proximity to polluted sites (including landfills, hazardous waste sites and industrial facilities) might contribute to adverse reproductive outcomes, especially congenital malformations and low birth weight—though not mortality. This body of evidence has limitations that impede the formulation of firm conclusions, and new, well-focused studies are called for. The review findings suggest that continued strengthening of rules governing industrial emissions as well as industrial waste management and improved land use planning are needed.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Bibliographic Materialsmentioning

confidence: 99%

Section: Bibliographic Materialsmentioning

confidence: 99%

Section: Bibliographic Materialsmentioning

confidence: 99%

See 2 more Smart Citations

Systematic literature review of reproductive outcome associated with residential proximity to polluted sites

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Within the last ten years, data from regional congenital anomaly registers and from NCAS have contributed to a number of studies. These include studies of congenital anomaly risk among populations living in close proximity to landfill sites (Dolk et al, 1998b;Vrijheid et al, 2000aVrijheid et al, , 2002bElliott et al, 2001;Morris et al, 2003;Boyle et al 2004;Palmer et al, 2005), and to incinerators (Cresswell et al, 2003;Dummer et al, 2003), as well as to possible contaminants present in water such as lead (Macdonell et al, 2000) and fluoride (Lowry et al, 2003), and in soil (ElizaguirreGarcia et al, 2000). The findings from such studies have ranged from no excess risk to small, elevated risks in particular congenital anomaly subtypes.…”

Section: Use Of Data From Congenital Anomaly Registers In Environmentmentioning

confidence: 99%

Congenital Anomalies in the British Isles

Rankin

Environmental Science and Technology Library

View full text Add to dashboard Cite

SummaryThe first congenital anomaly register in the British Isles was established in 1949, with a national system for England and Wales introduced in 1969 in the wake of the thalidomide epidemic. There are now 14 regional congenital anomaly registers and three disease-specific registers. These registers involve an extensive local network of notifiers, use multiple sources of case ascertainment, consistent coding, and include cases resulting in termination of pregnancy for fetal anomaly following prenatal diagnosis. They have optimised the coverage, completeness and ascertainment of congenital anomalies within their population, and are therefore able to provide better quality data than the national system. There are notable variations in the prevalence of congenital anomaly subtypes within these regions that cannot be accounted for in terms of differences in case ascertainment or registration practices. This underlying variation in prevalence should be recognised and taken into consideration in the design of epidemiological studies that are investigating the contribution of environmental influences to congenital anomaly risk, to ensure correct interpretation of the findings. Local congenital anomaly register data has been used to investigate congenital anomaly risk in populations within the British Isles living close to landfill sites and incinerators, and to possible contaminants in drinking water. Whilst the inclusion of high quality data from established congenital anomaly registers enhances the quality of outcome data, such studies are currently limited by the lack of detailed information on exposure. Causal pathways will only , J. RANKIN 360 be determined if future studies combine high quality congenital anomaly data with increased information on exposure assessment.

show abstract