Risk of colorectal cancer in relatives: A case control study

Azadeh, Safaei; Dehkordi, B Moghimi; Reza, Fatemi Seyed Mohammad; Maserat, Elham; Malek, Fatemeh; Gholi, Pourhossein; Zali, Mohammad Reza

doi:10.4103/0019-509x.58855

Cited by 19 publications

(9 citation statements)

References 13 publications

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“…Screening of people with positive family history must begin at age 40 or 10 years earlier than the youngest family member was diagnosed (6,14). An Iranian study indicated the risk of colorectal cancer in people with at least one first-degree relative affected is 2 times more and their disease often occurs below age 40, in right colon, with a worse prognosis (18,19). Therefore, the national protocol recommends people with positive family history participate in colonoscopy screening program interval.…”

Section: Introductionmentioning

confidence: 99%

“…However, a large number do not undergo this effective test (8,12). Reports from Foreign Studies indicated decision to participate colonoscopy screening in relatives was 25% -79% (19,20). Another study at Telavive reported only 23% first degree relatives participated in alternative colonoscopy screening and this adherence was higher among persons 40 to 59 years, women, sib- lings, married, high income and education level.…”

Section: Introductionmentioning

confidence: 99%

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Participation Rate and Related Factors in Colonoscopy Screening Program in First-Degree Relatives of Patients Affected by Colorectal Cancer

et al. 2016

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Background: First-degree relatives (FDRs) of people diagnosed with colorectal cancer (CRC) have a two-to three-fold increased risk of developing disease. Colonoscopy screening test can be effective in prevention and early treatment. Objectives: The purpose of this study was to determine the rate of participation in colonoscopy screening test and related factors in first degree relatives. Methods: 200 FDRs of CRC cases were interviewed by the researchers. A reliable and valid questionnaire about undergoing colonoscopy screening test and barriers was filled via phone. To report qualitative data results, we used percent and proportion. Full (bytotal variables) and final (Forward LR) multiple logistic regression analysis were used to make a model which was executed using spss19. Results: In total, 59% FDRs had undergone colonoscopy screening test to the time of interview. Major reasons for not participating were fear of pain (23%), concerns about complications and test positive result (21.5%), lack of health insurance (21.5%), not believing in the test effectiveness (17%), no need because of healthy feeling (13%), embarrassment (12%) and distrust to service provider skills (10%). Results of multiple logistic regression analysis indicated there is statistical significance between participating colonoscopy screening and variables "not affected with hypertension (95%CI: 0.4 -2.04, OR = 3.7), believe in test effectiveness in FDRs (95%CI: 1.8 -16.9, OR = 5.6), also age of

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Participation Rate and Related Factors in Colonoscopy Screening Program in First-Degree Relatives of Patients Affected by Colorectal Cancer

et al. 2016

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“…The Family history of colorectal cancer did not remain in the logistic regression model with the presence of other variables. Dehganzadeh et al [4] and Safaei et al [3] did the research and the results showed that the family history of colorectal cancer in first-degree relatives increased the risk of colorectal cancer 35.4 and 2 times, respectively. Our study showed a significant association between smoking and colorectal cancer and the results of the regression model showed that smoking increases the risk of developing colorectal cancer by 7.79 times.…”

Section: Discussionmentioning

confidence: 99%

“…This cancer is the third and fifth common type of cancer in Iranian women and men respectively [2]. Colorectal cancer is a Family history of colorectal cancer increase the risk of colon cancer in which approximately 12 -15% of patients those with family members who have colon cancer are at an increase risk of this disease [3]. Dehganzadeh et al carried out a study and concluded smoking, diabetes and inflammatory bowel disease and living without physical activities are risk factors of colorectal cancer [4].…”

Section: Introductionmentioning

confidence: 99%

The Role of Adverse Life Style Factors in the Cause of Colorectal Carcinoma in the Residents of Yazd, Iran

Lotfi

Keyghobadi

Javahernia

et al. 2016

Zahedan J Res Med Sci

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Background: This study was designed to investigate the role of lifestyle factors associated with colorectal cancer risk in the population living in Yazd city. Methods: This case-control study was conducted on 60 patients diagnosed with colorectal cancer and 120 subjects without any sign of colorectal cancer in the city of Yazd. Data was analyzed through SPSS16 and by using Chi-square test and Logistic regression. Results: The logistic regression model showed that smoking (OR = 7.79, P = 0.04) and History of diabetes (OR = 7.31, P = 0.04) were considered as associated risk factors for colorectal cancer. Conclusions:The present study showed that smoking and history of diabetes were positively associated with colorectal carcinoma.

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“…While an Iranian study showed that family history of cancer increased the risk of CRC (33), Weibull model did not detect any relation between risk of mortality and family history of CRC and this is similar to an Asian study which could not find any relation with survival of CRC and family history (34). Although in Iran there is evidence to support the screening of average risk individuals, including person with family history of colorectal cancer (35), it is still controversial and needs to more research on the Iranian population.…”

Section: Discussionmentioning

confidence: 99%

Demographic and Pathological Predictors of Colorectal Cancer Survival in Competing Risk Model, Using Generalized Weibull Distribution

et al. 2017

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Objectives: To investigate the prognosis factors of survival in patients with colorectal cancer in presence of competing risks, using generalized Weibull distribution, and to compare the results of Weibull model as well as semi parametric models. Methods:A total of 1462 patients with colorectal cancer, registered in cancer registry center of research institute of gastroenterology and liver disease (from 2004 to 2015), Taleghani hospital, Tehran, Iran entered this study. Death and the causes of death were confirmed via telephone contact to patients' families. The demographic and clinical features included age at diagnosis, sex, family history of CRC, body mass index (BMI), tumor size and tumor site extracted from hospital documents. Generalized Weibull distribution, Cox regression analysis and Fine-Gary model were used to assess the prognosis of CRC survival. The analysis was carried out using R software version 3.0.2. P value less than 0.05 were considered significant. Results:Overall, 1060 CRC patients with completed data were included in the analysis. 58% were men and the mean ± SD of age at diagnosis was 53.67 ± 0.46 years. The mean ± SD of survival time was 56.96 ± 1.46 with median = 45.5 months. 380 patients (35.5%) died from CRC and 49 patients (4.6%) died from other causes of death, such as myocardial infarction, stomach cancer, liver cancer etc. Generalized Weibull model with competing risk analysis and other models indicated age and BMI as the prognosis. Conclusions:This study indicated age and BMI as the prognosis, using a generalized Weibull model with competing risk analysis. Also according to the survival curve estimation, generalized Weibull model with competing risk has a better fit to the data, compared to Weibull model.

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Risk of colorectal cancer in relatives: A case control study

Cited by 19 publications

References 13 publications

Participation Rate and Related Factors in Colonoscopy Screening Program in First-Degree Relatives of Patients Affected by Colorectal Cancer

Participation Rate and Related Factors in Colonoscopy Screening Program in First-Degree Relatives of Patients Affected by Colorectal Cancer

The Role of Adverse Life Style Factors in the Cause of Colorectal Carcinoma in the Residents of Yazd, Iran

Demographic and Pathological Predictors of Colorectal Cancer Survival in Competing Risk Model, Using Generalized Weibull Distribution

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