Risk of Colorectal Cancer in Patients With Acute Diverticulitis: A Systematic Review and Meta-analysis of Observational Studies

Abstract

In a meta-analysis of observational studies of patients with acute diverticulitis, we found the pooled prevalence of colorectal cancer to be 1.9%. The risk of colorectal cancer was significantly higher in patients with complicated diverticulitis than in patients with uncomplicated diverticulitis.

Long-term follow-up of the AVOD randomized trial of antibiotic avoidance in uncomplicated diverticulitis

“…A recent systematic review reported a pooled prevalence of colorectal cancer in patients with uncomplicated diverticulitis of 1·3 per cent, compared with 7·9 per cent in patients with complicated diverticulitis. The present study pool had low rates of colorectal cancer, of 0·4 and 2·1 per cent in the no‐antibiotic and antibiotic group respectively.…”

Colonoscopy Should Be Performed After an Episode of Uncomplicated Diverticulitis

“…In a systematic review and meta-analysis performed this year, we found a pooled prevalence of colorectal cancer of 1.3% (95% CI 0.1-2.0%) among 3,834 patients (15 studies) with uncomplicated episodes [3]. Further, a recent publication, not included in these meta-analyses, indicated the prevalence of colorectal cancer to be 1.8% in a cohort of 227 patients with uncomplicated diverticulitis [4].…”

Author response to Comment on: Meta-analysis of the role of colonoscopy after an episode of left-sided acute diverticulitis

“…0·2 to 1·2) per cent prevalence in patients with CT‐proven, left‐sided and uncomplicated (Hinchey 1a) diverticulitis who underwent colonoscopy. The meta‐analysis of Meyer et al . yields a pooled prevalence of 1·3 (95 per cent c.i.…”