Risk of Coinfection with <i>Chlamydia trachomatis</i> and <i>Neisseria Gonorrhoeae</i> in Nova Scotia

Forward, Kevin R.

doi:10.1155/2010/760218

Cited by 24 publications

(13 citation statements)

References 7 publications

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Section: Discussionmentioning

confidence: 60%

“…22 For gonorrhea, our positivity rates were 33.1% in males and 15.9% in females compared with 22% in males and 11% in females in the United States, 21 as well as compared with 2.4% in males and 0.2% in females in Canada. 22 For coinfection, our positivity rates were 10.2% in males and 10.1% in females compared with 0.9% in males and 0.1% in females in Canada. 22 In general, approximately half of the adolescents who were tested positive in our study reported at least 1 symptom or sign, and the proportion of females who were symptomatic was higher than that of the males.…”

Section: Discussionmentioning

confidence: 60%

“…22 For coinfection, our positivity rates were 10.2% in males and 10.1% in females compared with 0.9% in males and 0.1% in females in Canada. 22 In general, approximately half of the adolescents who were tested positive in our study reported at least 1 symptom or sign, and the proportion of females who were symptomatic was higher than that of the males. Concern over symptoms or signs, constituting approximately 40% of clinic encounters, was one major factor leading to the corresponding high positivity rates.…”

Section: Discussionmentioning

confidence: 61%

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Determinants of Chlamydia, Gonorrhea, and Coinfection in Heterosexual Adolescents Attending the National Public Sexually Transmitted Infection Clinic in Singapore

Lim¹,

Wong²,

Cook³

et al. 2015

Sexually Transmitted Diseases

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Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 60%

Section: Discussionmentioning

confidence: 61%

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Determinants of Chlamydia, Gonorrhea, and Coinfection in Heterosexual Adolescents Attending the National Public Sexually Transmitted Infection Clinic in Singapore

Lim¹,

Wong²,

Cook³

et al. 2015

Sexually Transmitted Diseases

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“…and Neisseria gonorrhoeae have been described often in screening programs and clinical settings; patients with gonorrhoeae also have been reported to have a concurrent chlamydial infection in less than 1% to a high of 70% of individuals, thus demonstrating wide variation depending on the population examined. [ 14 , 15 , 16 , 17 , 18 , 19 ]. Other coinfections of relevance in urogenital contexts include genital mycoplasmas and genital ureaplasmas.…”

Section: Introductionmentioning

confidence: 99%

Coinfection of Chlamydiae and other Bacteria in Reactive Arthritis and Spondyloarthritis: Need for Future Research

Zeidler

Hudson

2016

Microorganisms

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Reactive (inflammatory) arthritis has been known for many years to follow genital infection with the intracellular bacterial pathogen Chlamydia trachomatis in some individuals. Recent studies from several groups have demonstrated that a related bacterium, the respiratory pathogen Chlamydia pneumoniae, can elicit a similar arthritis. Studies of these organisms, and of a set of gastrointestinal pathogens also associated with engendering inflammatory arthritis, have been relatively extensive. However, reports focusing on coinfections with these and/or other organisms, and the effects of such coinfections on the host immune and other systems, have been rare. In this article, we review the extant data regarding infections by multiple pathogens in the joint as they relate to engendering arthritis, and we suggest a number of research areas that must be given a high priority if we are to understand, and therefore to treat in an effective manner, such arthritides.

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“…trachomatis infections (5,8,14,16), showing a wide range depending on the population examined. Although we were unable to examine our database for dual infections, a current 2-month determination showed similar prevalence rates due to dual combo testing (C. trachomatis, 2.9%; N. gonorrhoeae, 0.29%) with 48 patients infected with both.…”

mentioning

confidence: 99%

Aptima Combo 2 Testing Detected Additional Cases of Neisseria gonorrhoeae Infection in Men and Women in Community Settings

Kapala¹,

Biers²,

Cox³

et al. 2011

J Clin Microbiol

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Aptima Combo 2 (AC2) Neisseria gonorrhoeae testing of 81,405 patients who were tested by culture and 14,666 who were AC2 tested for Chlamydia trachomatis detected 142 extra infections and confirmed 106 culture-positive samples (the positivity rate increased from 0.13 in testing by culture to 0.26 in testing by AC2). Retrievable AC2 positive samples were confirmed (98.5%) by an alternate AGC test.Lower genital tract infections with Neisseria gonorrhoeae may be asymptomatic and accompanied by Chlamydia trachomatis infection(13). Efforts are needed to identify and treat lower tract infections to prevent upper tract complications, such as pelvic inflammatory disease, ectopic pregnancy, or tubal infertility in women and less commonly epididymitis or prostatitis in men, as well as transmission between asymptomatically infected patients and their uninfected partners. Attempts to culture N. gonorrhoeae from clinical specimens can be unsuccessful. Testing for N. gonorrhoeae with nucleic acid amplification tests (NAATs) has increased diagnostic sensitivity (3,4,9,11,18,19) using traditional and less-invasive sampling. Although not all are FDA cleared, first-void urine (FVU), self-collected vaginal swabs (VS), and anal and oral swabs have been shown to yield positive results (1,7,15). The commercially available transcription-mediated amplification (TMA) test Aptima Combo 2 (AC2) is able to detect N. gonorrhoeae and C. trachomatis RNA in clinical specimens collected in specimen transportation media (STM), with no crossreactions with non-N. gonorrhoeae strains. Positives can be confirmed in alternate individual TMA tests, Aptima GC (AGC) (for N. gonorrhoeae) and APTIMA CT (ACT) (for C. trachomatis) (2, 12).Community physicians practicing in Southern Ontario who suspect that their patient may have an N. gonorrhoeae infection traditionally submit cervical swabs (CS) from women and urethral swabs (US) from men for culture. If a C. trachomatis infection is suspected, an NAAT will be ordered for a CS or FVU. If both infections are suspected, specimens are collected for N. gonorrhoeae culture and C. trachomatis nucleic acid amplification testing. We evaluated the utility of performing additional AC2 testing for N. gonorrhoeae on specimens submitted for N. gonorrhoeae culture and C. trachomatis TMA. The objectives were as follows: (i) to perform N. gonorrhoeae testing by AC2 on STM samples from patients receiving N. gonorrhoeae culture, (ii) to test STM samples submitted for C. trachomatis testing for N. gonorrhoeae, and (iii) to confirm AC2-GC positives using the AGC assay.From March to August 2008, the microbiology laboratory at Gamma Dynacare Medical Laboratories in Brampton, Canada, received 96,071 urogenital samples from 961 men (FVU or US) and 95,110 women (FVU or CS) for C. trachomatis and N. gonorrhoeae testing or C. trachomatis testing only (Fig. 1). There were 81,405 patients in group A, whose physicians submitted a swab collected in an M40 Transystem specimen transport system (Copan Diagnostics Inc.) for N. gonorrhoeae c...

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Risk of Coinfection with Chlamydia trachomatis and Neisseria Gonorrhoeae in Nova Scotia

Cited by 24 publications

References 7 publications

Determinants of Chlamydia, Gonorrhea, and Coinfection in Heterosexual Adolescents Attending the National Public Sexually Transmitted Infection Clinic in Singapore

Determinants of Chlamydia, Gonorrhea, and Coinfection in Heterosexual Adolescents Attending the National Public Sexually Transmitted Infection Clinic in Singapore

Coinfection of Chlamydiae and other Bacteria in Reactive Arthritis and Spondyloarthritis: Need for Future Research

Aptima Combo 2 Testing Detected Additional Cases of Neisseria gonorrhoeae Infection in Men and Women in Community Settings

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