Risk of chronic pancreatitis in carriers of the c.180C&gt;T (p.Gly60=) CTRC variant: case-control studies and meta-analysis

Berke, Gergő; Beer, Sebastian; Gede, Noémi; Takáts, A.; Szentesi, Andrea; Hegyi, Péter; Rosendahl, Jonas; Sahin–Tóth, Miklós; Németh, Balázs Csaba; Hegyi, E

doi:10.1016/j.pan.2023.05.013

Cited by 4 publications

(1 citation statement)

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“…CTRC is expressed in the pancreas as an inactive proenzyme that is activated by trypsin. It is required for full activation of other digestive proteases and degrades excess trypsinogen to protect against excess trypsin activity ( 66 ). Jon99C proteins likely activate Chs2 in a similar manner.…”

Section: Discussionmentioning

confidence: 99%

Cellular and molecular organization of the Drosophila foregut

Zhu,

Ludington,

Spradling

2024

Proc. Natl. Acad. Sci. U.S.A.

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The animal foregut is the first tissue to encounter ingested food, bacteria, and viruses. We characterized the adult Drosophila foregut using transcriptomics to better understand how it triages consumed items for digestion or immune response and manages resources. Cell types were assigned and validated using GFP-tagged and Gal4 reporter lines. Foregut-associated neuroendocrine cells play a major integrative role by coordinating gut activity with nutrition, the microbiome, and circadian cycles; some express clock genes. Multiple epithelial cell types comprise the proventriculus, the central foregut organ that secretes the peritrophic matrix (PM) lining the gut. Analyzing cell types synthesizing individual PM layers revealed abundant mucin production close to enterocytes, similar to the mammalian intestinal mucosa. The esophagus and salivary gland express secreted proteins likely to line the esophageal surface, some of which may generate a foregut commensal niche housing specific gut microbiome species. Overall, our results imply that the foregut coordinates dietary sensing, hormonal regulation, and immunity in a manner that has been conserved during animal evolution.

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Section: Discussionmentioning

confidence: 99%